Latest

new The great technological leaps forward of the past—from the advent of the steam engine to personal computers and the internet—each empowered humans by augmenting their physical and computational capabilities. The artificial intelligence technologies of today, however, expand the domain of technological augmentation to areas long thought to be uniquely human, like creativity. Generative AI’s mastery of what was considered distinctly human means it impacts the professional identity of knowledge workers in ways that we have not seen before, portending a future that looks very different from the world today.Fortune, 9h ago
new At the beginning of ECP, EQSIM could resolve motions of 2 Hertz in a material model where the shear speed exceeds 500 meters per second. Now, the team has achieved 10 Hertz in a model that resolves motion down to a shear speed of 140 meters per second—providing a far more realistic predictive tool for validating infrastructure risk. “Earthquake hazards and risks are a problem of national importance,” says McCallen. “The damage that could result from a large earthquake is a bigger societal problem than most people imagine.” Indeed, according to USGS and the Federal Emergency Management Agency, earthquakes cost the nation an estimated $14.7 billion annually in building damage and related losses. Says McCallen, “We’ve really pushed the envelope of what is possible computationally and made tremendous advancements. EQSIM has become a practical tool for realistically evaluating and planning for the effects of future earthquakes on critical infrastructure, providing a basis for objectively and reliably designing or retrofitting structures.”...HPCwire, 19h ago
new Chen’s laboratory in Weizmann’s Brain Sciences Department focuses on the molecular and behavioral aspects of the response to stress. In previous studies, Chen’s team examined how stress during pregnancy affects mouse offspring when they reach maturity. In the current research, the scientists, led by Dr. Aron Kos, studied how trauma experienced shortly after birth affects mouse pups later in life. To advance the understanding of this topic, the researchers pulled together the strengths of Chen’s lab: its expertise in exploring the brain’s molecular processes at the highest possible resolution, using genetic sequencing on the level of individual cells; the ability to use cameras to track dozens of behavioral variables in a rich social environment intended to recreate natural living conditions; and the ability to process the massive quantities of data generated in this environment, using machine learning and artificial intelligence tools.Weizmann Wonder Wander - News, Features and Discoveries from the Weizmann Institute of Science, 1d ago
new The suggestion is that relational actors do not seek to merge into a homogenous international society, but aspire for the dialogical management of their differences through interaction so that these do not lead “to conflict and disorder, but on the contrary, can add up to stability” (Qin 2016, 39). Qin’s proposition is that in such a dynamic context power itself is relational. Rather than a material possession or an equation of capabilities, power becomes a contingent reflection of intersubjective and circumstantial relational practices. As a result, the capacity to act transpires as a function of the ongoing ability of social actors to adapt, manage, and navigate the multiplicity of flows animating their “relational circles; an actor is more powerful because she has larger relational circles, more intimate and important others in these circles, and more social prestige because of these circles” (Qin 2016, 42). In this setting, both “relations are power” and “relations always influence [enlarge and/ or constrain] the exercise of power” (Qin 2009, 16-18).E-International Relations, 1d ago
new Finer control over the visual characteristics and notions represented in a produced picture is typically required by artistic users of text-to-image diffusion models, which is presently not achievable. It can be challenging to accurately modify continuous qualities, such as an individual’s age or the intensity of the weather, using simple text prompts. This constraint makes it difficult for producers to alter images to reflect their vision better. The research team from Northeastern University, Massachusetts Institute of Technology, and an independent researcher respond to these demands in this study by presenting interpretable idea Sliders, which enable fine-grained idea manipulation inside diffusion models. Their approach gives artists high-fidelity control over picture editing and generating. The research team will provide their trained sliders and code as open source. Concept Sliders offers several solutions to issues that other approaches must address adequately.MarkTechPost, 1d ago
new In my book Why? I focus on the work of the great philosopher of religion Richard Swinburne in responding to the problem of evil. Swinburne argues that there are goods that exist in our universe that would not exist in one with less suffering. If we just lived in some kind of Disneyland-esque world with no danger or risk, then there would be no opportunities to show real courage in the face of adversity, or to feel deep compassion for those who suffer. The absence of such serious moral choices would be a great cost, according to Swinburne.Aeon, 1d ago

Latest

new New ways of studying the brain only meant new ways of trying to find the difference that many remain sure is there, lest it reveal the reason behind supposedly sex-specific behaviors. As Rippon explains, “In looking for sex differences, neurologists cheerily matched their assumptions about which bits of the brain were the most important to their findings about which bits of the brain were largest in males, even if it meant reversing earlier conclusions.”...IFLScience, 2d ago
new Let’s move from the ancient Greeks to a more recent phenomenon, the effects of neuroscience on understanding choice. Some people have suggested that various neuro-scientific experiments undermine this notion that we have free will at all. They are providing empirical evidence that free will is actually an illusion. Something as simple as moving my hand, the neurophysiological impulse that brings about that movement occurs before I have the intention of moving it, even though it feels the other way around. That’s what Benjamin Libet claims, and it’s quite a radical claim. There may be flaws in the experiment, but a lot of neuroscience is piling up to suggest that picture of ourselves as somehow sitting in the driving seat may be wrong.Five Books, 2d ago
new It seems to me that, on the authors’ view, an important input to “human alignment” is the environment that we’re trained in (rather than details of our brain’s reward circuitry, which is probably very simple). It doesn’t seem to me that environmental factors that make humans aligned (with each other) should generalize to make AI systems aligned (with humans).alignmentforum.org, 2d ago

Top

This is where the uniquely human skill to think critically becomes indispensable. Logical reasoning enables us to dissect AI outputs, identifying potential flaws or inconsistencies. Reflective thinking encourages employees to consider the broader implications and contexts of the information presented to them. Rational thought allows us to weigh the evidence, discerning between the relevant and the extraneous. Unbiased evaluation ensures that we remain vigilant to potential biases, both from the AI and from our own preconceptions. Employees cannot afford to be passive recipients of generative AI output. They must become active evaluators, synthesizers, and decision-makers. An employee’s ability to critically assess, challenge, and refine AI outputs will determine the success of the human-AI collaboration.Fast Company, 17d ago
...- If you look at the way that we come to understand the world, there are poets, there are musicians, there are high-energy physicists, there are mathematicians. What is it about the Universe, living and non-living, that that seems to require very different forms of expertise? Now, there are people who say, "We don't, in the end it's just quantum field theory, all that stuff, it's just noise. If we really understood the Universe deeply, we'd just all be physicists." And of course, many of us consider that very muddle headed. So how do you explain the need for new ideas, new disciplines, at different scales of organization? And that's where emergence comes in. And it turns out that one of the interesting properties of the Universe and the world is that it can be understood as a set of hierarchies, each of which becomes somewhat independent of the levels below. Right, and understanding how that comes about is the 'emergence problem.' Right, and the way I often say this is that if you go to a new city and you need to get around and you go to rent a car, what you need to understand is the map of the city, not the physics of the engine. And COVID for me was the "come to Jesus moment" of reckoning with excessive specialization. Because what happened with COVID, it was a virus, right? It becomes an immunological problem that becomes an epidemiological problem, which becomes a transport problem, which becomes an economic problem, which becomes a human well-being and professions problem, which becomes a school problem, etc. So what happened during the course of the pandemic is that our sensibilities matured in understanding that what we are dealing with here was a complex system. There were other dimensions to this problem that were being neglected precisely because we were not reckoning with the interconnectedness of the system. So it's not just that it's the neglect, it's actually pathologically dangerous for the well-being of the planet that we do this kind of atomization all the time at the level of the disciplines.Big Think, 20d ago
One widely disseminated claim surrounding mirror neurons is the “broken mirror theory,” which suggests that dysfunctions in the mirror neuron system are to blame for autism. Deficient mirror neurons, the theory goes, underly the difficulties autistic people have in understanding others’ intentions or empathizing with their emotions. However, some influential research reviews have disputed this claim, for both behavioral and structural reasons; for example, while there are differences between autistic and non-autistic brains, they are not currently apparent in the parts of the brain thought to contain mirror neurons.Psychology Today, 23d ago
The classic and original text that first explored the telepathic methods of communication of wild animals • Based on years of detailed field observations, first published in 1919 • Written by the famous American naturalist who was the first to study telepathy in the wild • Forewords by biologists Rupert Sheldrake, who has spent 15 years researching the unexplained powers of animals, and Marc Bekoff, the editor of the three-volume Encyclopedia of Animal Behavior Many sources have commented on the silent communication abilities of pets, but never before and not since the first publication of this book in 1919 has the subject of animal telepathy in the wild been so fully researched. How Animals Talk explores the phenomenon of vocal, silent, and even motionless communication among animals. From crow talk to instant herd communication, author William J. Long theorizes that animals are much more intelligent, emotional, and moral than we have traditionally thought and that their ability to sense the presence of other living beings is an innate ability shared by humans as well. Based on many years of field observations, this classic text contains numerous examples of animal behavior that defy conventional explanation. Long believed in the importance and validity of anecdotal evidence. He recognized the dangers of conventional research in reducing animals to mere numbers and how the cold third-person prose of scientific study can objectify animals, distancing "us" from "them." His findings on the impact of our presence on animal life--and the cost that we pay in separating ourselves from animals, who help define our place in the natural world--may be more relevant today than ever before.innertraditions.com, 14d ago
Consider this description of America's discontent:"...a Hamlet-like loss of self-confidence, with an apocalyptic sense of doom for the civilization. On the Right it embodies a conviction that the sensate culture is pushing the society down the Gaderene slope of drugs-and-fornication to destruction. On the Left there is the vague sense that America is imperialist, fascist-oriented, caught in inner contradictions of class and ethnic struggles which will end in self-destructive wars or civil chaos....the fragmenting and polarizing of institutions (family, neighborhood, university, church, nation)--in short, the overloading of the social nervous system by sudden accelerations of change."Is that a reasonably fair description of America in 2023? Interestingly, it was written in January 1974, describing the America of 50 years ago. (America Agonistes (Max Lerner, Foreign Affairs, January 1974). I have often referred to Peter Turchin's evidence-based cyclical mapping of the structural sources of social disorder which he has updated in his latest work, End Times: Elites, Counter-Elites, and the Path of Political Disintegration.Turchin identified 50-year cycles of integration--in which people find reasons to cooperate--and disintegration, in which people find reasons to devolve cooperation. From this perspective, that an article from 50 years ago sounds current is not only no surprise, it was easily predictable.This Salon article summarizes many of the conclusions in Turchin's new book: Hope in "End Times": Peter Turchin's analysis of our coming collapse could help us avoid it:For all its breadth and depth, there's a simple message at the core of "End Times": At the heart of our problems, Turchin writes, is "a perverse 'wealth pump' ... taking from the poor and giving to the rich," and we have to find a way to turn it off.This reflects "one of the most fundamental principles in sociology, the 'iron law of oligarchy,'" he writes, "which states that when an interest group acquires a lot of power, it inevitably starts using that power in self-interested ways." For example, while wages fell far behind the growth of economic productivity from 1979 onward, Turchin cites analysis from the Economic Policy Institute indicating that three-fourths of that gap was due to elite-driven policy shifts: weakened labor standards, the erosion of collective bargaining, corporate globalization and so-called fiscal austerity.Diminished economic conditions for the less educated were accompanied by a decline in the social institutions that nurtured their social life and cooperation. These institutions include the family, the church, the labor union, the public schools and their parent-teacher associations, and various voluntary neighborhood associations."Back in America's previous cyclical crisis, Lerner identified the sources of decline in this way: "Civilizations die not only of rigidity, failure to meet challenges, constitutional breakdown. They may also die of deep alienations and the erosion of crucial institutions."He concluded that America's cult of change precluded a decline due to rigidity:"My own stress is on studying the crucial factors in the death of past civilizations, and using them to put questions concerning American directions. To start with, the rigidity which marked a number of declines and falls is only minimally present in America, with her cult of change and her experience of social and cultural revolution."I will consider the issue of rigidity in upcoming posts, but for now, let's consider the decay of America's social and economic foundations, starting with Turchin's perverse wealth pump that has stripmined the bottom 90% to enrich the top 1%, as shown in this chart:...substack.com, 21d ago
Through evaluating the structural and functional connectivity properties of shared and unique peaks, we observed that shared peaks exhibit larger connectivity attributes, such as degree, strength, clustering coefficient, betweeness and efficiency, compared to unique peaks. Higher degree and strength values suggest that shared peaks are connected to more vertices in the brain network. Additionally, we found that clustering coefficient and efficiency, which measure local information transmission capacity and resilience to random attacks in a network, were higher in shared peaks. Betweeness, a centrality measure that quantifies the importance of a node in the network, also showed higher values for shared peaks, indicating greater importance of these peaks in the brain network. These results suggest that shared peaks may play a role as network hubs in contrast to unique peaks. Gyral peaks exhibit a high degree of connectivity within local neighborhoods, creating a “small world” structure within the network, and may behave as hubs in the structural/functional network, as suggested by previous studies (Sporns and Zwi (2004); Bassett and Bullmore (2006); Bullmore and Sporns (2009); He and Evans (2010)). In many studies, higher-order brain regions like the DMN are recognized as the global network hubs and the communication centers of the brain’s global network. These regions typically exhibit higher node degree and strength. However, there is an interesting finding in our study. That is, most of the shared peaks, mainly distributed in lower-order brain regions, have larger network properties compared to the unique peaks, mainly distributed in higher-order brain regions. There are two possible explanations for this. Firstly, peaks is defined at a much more local scale, in contrast to the definition of brain functional regions, such as DMN. This seemingly contradictory findings could be reconciled by their definitions of “network hubs” at respective coarse and fine scales. Specifically, while higher-order brain regions such as DMN serve as the information exchange centers for large-scale brain network, the information transfer within each region at a finer scale could be primarily facilitated by loci, such as the shared peak. These findings suggest that, peaks that are in larger-scale DMN while exhibiting lower hub-like attributes at a vertex-level, could be referred to as provincial hubs (Guimera and Nunes Amaral (2005); Hwang et al. (2017)). This can be understood as the preservation of the most fundamental and mainstream topological structure and communication patterns during the evolutionary process of species, while species-specific peaks that appear later in the evolutionary process may serve higher-order and more specific functions (Goulas et al. (2014); Rilling (2006)). Another issue worth discussing is the relationship between degree and clustering coefficient. Some studies focusing on social networks and random intersection graph models have found that clustering coefficient correlates negatively with degree Foudalis et al. (2011); Bloznelis (2013). While in our study, when comparing the functional network characteristics of shared and unique peaks, we found that the patterns of degree and clustering coefficient were similar (3). The differences in network characteristics between brain networks and social networks or random networks may reflect distinct organizational patterns in the brain compared to other networks. Furthermore, due to our focus on the internal properties of peaks in our study, the patterns observed may not align entirely with the principles followed by the entire brain network.elifesciences.org, 12d ago

Latest

new One of the features in the development of pragmatism is that pragmatists are constantly faced with the challenge of taking science seriously, but not losing sight of evaluative questions, moral questions, social and political questions. We saw that driving James’s pragmatism was the need to reconcile science and values in a very broad sense. We saw that Dewey thinks that the values, in effect, start the whole thing, that’s how you keep them reconciled: you start with the social, the political, the normative. Quine has only one essay about values and it’s very short. His work is all about philosophy of science, philosophy of logic, epistemology and philosophy of language, and that sort of thing. Misak is a very interesting figure in this very long story of pragmatism. She publishes Truth, Politics and Morality in 2000 and it’s a return to Peircean pragmatism for the purpose of getting democratic theory right. Peirce himself, like Quine, wrote almost nothing about values. He certainly wrote nothing about politics, philosophically. In letters that we have where Peirce does talk about politics he says very unfortunate things about slavery, about women, and about democracy. So it’s a strange return to Peirce for the repurpose of moral and political philosophy. Here’s the nub of the book: We talked earlier about Peirce’s conception of meaning and the pragmatist’s maxim, the idea that epistemology is about conduct. That’s the core, the germ of the thought that Misak is developing here. As it turns out, Peirce thought a very funny thing about truth that Misak is reviving and, in a way, trying to clarify. Peirce thought that “truth is what an ideal community of enquirers is fated to believe.” In other words, he thinks that the truth is the ideal end point of enquiry, what we will come to believe if we continue enquiring. It’s called the “end of enquiry” conception of truth and, like James, Peirce articulates this thought in a lot of unfortunate ways. It seems an odd thought and you might think it gets the explanatory relation backwards. You might say, “No, no wait a minute! It’s the truth of the proposition that explains the convergence of opinion in the course of enquiry. It’s not the convergence of opinion in the course of enquiry that explains the truth.” Misak gives, I think, a much more promising gloss on that thought. She’s saying: this is how Peirce should have expressed it, this is what Peirce really means. Peirce thinks, like a good pragmatist, that if you’re interested in understanding a philosophical concept, we’ve got to draw out its implications for human practice. Peirce thinks that what we are doing when we are attributing truth to a particular belief is we are affirming, “Nigel, go and enquire — you’ll come to agree with me.” Or, “If we keep looking at reasons and keep challenging this thought, it’s going to stand up to the challenges. It’s almost a [John Stuart] Millian idea, that what we are doing with truth talk is making a prediction about the ability of a particular belief to which we attribute truth to withstand philosophical scrutiny and answer objections.Five Books, 2d ago
new Pizza Hut has been in the UK for 50 years and when we started, we were predominantly a restaurant business, which has expanded into a considerable portfolio of 150 restaurants. But over the years, customers have changed and so have their expectations and how they want to interact with brands. So now we have 370 delivery express units and we are adapting further in the future with all of our platforms accessible through our app. It’s an increasingly disrupted, unpredictable and changeable world in all sectors today and so being agile and creative about every aspect of the business is essential to staying relevant and competitive. You cannot afford to stop listening to your customers, particularly the criticisms. Our plan is to become even more digital, with a brand that is relevant to younger consumers coming through and that means operating sustainably and making the right choices about how we operate. The danger is, after 50 years of success, complacency can start to creep in and there are many businesses that have fallen foul of that. So, staying close and attuned to our customers is extremely important.theHRDIRECTOR, 2d ago
new KAREN HAO: I think it was a very tumultuous and very emotional and very sleep deprived period of days after Altman was fired and reinstated for the employees. Of course, like you said, none of them knew that this was happening, they had no idea what was going on and the board never explained really why they had ultimately fired Altman. And so it kind of, the, the progression of like their emotions went from like confusion to fear when Brockman leaves and then three senior research scientists also leave two anger at the board, like really, really deep anger because they were like, "If you're going to do something dramatic, we deserve answers as employees." And when they didn't, the, the longer they didn't get answers, the more and more worked up it became. And part of this is, I mean many companies within Silicon Valley have this- they really emphasize that companies are families and you as an employee are not just an employee of any company, you, it is your identity OpenAI takes this to the max, like the fact that they say that their mission is for the benefit of humanity. Like people genuinely believe this and they think that this is like they're dedicating their life to this. It's not just like, "This is my job and then I go home." This is like all, all they think about sometimes. And so it's like that level of anger of like, if you are going to do something that could ruin this company that we genuinely believe is doing good for the world, like how dare you not tell us why and how dare you continue to kind of leave us in the dark and and and not treat us as like critical stakeholders in this, in this whole fiasco. And so what happened was kind of organically the employees started rapidly organizing on Twitter. So they, they started like posting very similar messages by the hundreds kind of on Twitter of like every time Sam Altman said, "I love OpenAI so much, I miss it." You know, you would see like employees retweeting it with a heart emoji and just it would, like when I opened my Twitter feed, it was just like dozens and dozens and dozens of heart emojis. Not because I was looking at any like OpenAI specific feed that was just what was showing up on my regular feed. And then there were the the like OpenAI is nothing without its people that everyone started tweeting as well. And that was sort of a way to try and pressure the board to give answers. And then of course that ultimately escalated to over 700 employees outta 770 signing a letter saying that like, if Sam is not reinstated, they're all gonna quit. And so I think another dimension that's sort of important to add to this is most if not all of the OpenAI employees, their compensation packages are majority stock and Bloomberg has a good article on this, you know like the average compensation is around like 800,000 to a million dollars and maybe 60% or something of that like that is actually stock. So if a company, if the company does not exist anymore, all of a sudden your stock goes to zero. And that was also extremely stressful for people because people were banking on, you know, some, some people were, had already bought houses based on projected income or were looking to buy houses based on the projected income that were suddenly worried about paying their mortgage. There were people that were on visas that if the company doesn't exist anymore and they don't get hired fast, then their ability to stay in the country is jeopardized and maybe they already have family and then like, you know, that's gonna throw their entire family into disarray as well. So there were a lot of other aspects of it, not just the identity or the ideology piece that led employees to kind of have this very emotional and tumultuous time. And when Altman was reinstated there were some great details that were reported in the information about how employees like gathered at the office and they were crying and cheering and just, it was like a huge massive sigh of relief honestly, that they have their jobs still and that this company still exists and all the things that they've been working towards are going to continue to exist in some form or other and that they can move on with their lives, basically.Big Think, 2d ago
Excessive dependence on AI has the capacity to erode human empathy, logical thinking, innovation and interpersonal abilities as well. As AI becomes more integrated into diverse facets of our existence, there is concern that it might endanger fundamental human characteristics and the bonds within our communities.Techiexpert.com, 3d ago
As the audience queued for coffee, they debated Smajdor’s proposal. Some women in the group commented that they had enjoyed being pregnant, that carrying a child had been a profoundly challenging but rewarding experience. Others described relentless morning sickness, hemorrhoids, “feeling like an elephant,” and being treated as public property—suddenly every stranger had an opinion on their bodies and behaviour. In weighing their experiences of pregnancy and birth, the perspectives of each of these women had been shaped by the sense that there was simply no other way. What makes Firestone and Smajdor’s argument so provocative is their invitation to think beyond this assumption, to ask how our attitudes toward pregnancy might change if, in fact, there was another way. Considered in the context of the scientific research of the past several years, Smajdor’s prediction about the end of sexual reproduction is not so hard to imagine after all.The Walrus, 3d ago
The future of medicine is shifting to cloud computing, where health care providers can access patient information from anywhere at any time. This transformative shift will facilitate rapid and efficient treatment decisions, which can be crucial in emergency situations. As the fields of AI and neuroscience advance, the development of methods to interpret brain activity becomes increasingly imminent. Recent studies have already demonstrated the feasibility of such interpretation for specific brain regions. Decoding patterns of neural activity will unlock insights into the underlying mechanisms of cognitive function and behavior, potentially revolutionizing medical treatments. However, these developments also present challenges to HIPAA regulation and raise additional privacy concerns for intellectual property derived from this information. Moreover, a basic goal of integrating AI into the medical field is to train agents to identify abnormal brain scans. To do this, datasets must be expanded by several orders of magnitude, because medical diagnoses often are highly individualized with significant variability in symptom characteristics. Ensuring data security is crucial in protecting patients’ privacy and encouraging participation in neuroimaging studies. Ultimately, the integration of AI and cloud computing has the potential to revolutionize various aspects of health care. Giordano’s research will help address a vital step toward this goal: the creation of a secure encryption method capable of handling large medical imaging file formats while preserving the content and patient privacy.newswise.com, 3d ago

Top

The preBötzinger Complex, which is a key region of brainstem circuits that generate and control breathing, contains neurons that also project widely, connecting to other regions of the brain. This helps to modulate the sense of smell, emotional state, heart rate, and even blood pressure. Understanding how the preBötzinger Complex is organized can untangle how breathing can influence these other processes.eLife, 18d ago
The complex of methyltransferase-like proteins 3 and 14 (METTL3-14) is the major enzyme that deposits N6-methyladenosine (m6A) modifications on mRNA in humans. METTL3-14 plays key roles in various biological processes through its methyltransferase (MTase) activity. However, little is known about its substrate recognition and methyl transfer mechanism from its cofactor and methyl donor S-adenosylmethionine (SAM). Here, we study the MTase mechanism of METTL3-14 by a combined experimental and multiscale simulation approach using bisubstrate analogues (BAs), conjugates of a SAM-like moiety connected to the N6-atom of adenosine. Molecular dynamics simulations based on crystal structures of METTL3-14 with BAs suggest that the Y406 side chain of METTL3 is involved in the recruitment of adenosine and release of m6A. A crystal structure representing the transition state of methyl transfer shows a direct involvement of the METTL3 side chains E481 and K513 in adenosine binding which is supported by mutational analysis. Quantum mechanics/molecular mechanics (QM/MM) free energy calculations indicate that methyl transfer occurs without prior deprotonation of adenosine-N6. Furthermore, the QM/MM calculations provide further support for the role of electrostatic contributions of E481 and K513 to catalysis. The multidisciplinary approach used here sheds light on the (co)substrate binding mechanism, catalytic step, and (co)product release catalysed by METTL3, and suggests that the latter step is rate-limiting. The atomistic information on the substrate binding and methyl transfer reaction of METTL3 can be useful for understanding the mechanisms of other RNA MTases and for the design of transition state analogues as their inhibitors.elifesciences.org, 4d ago
The truth is in the details, as he elaborates. When we talk to someone, there is an “intense” scanning that is taking place by our neurons. “As the visual information gets more details, the stimulation of the neurons is more intense, and corresponds to different areas of the brain,” he says.gulfnews.com, 20d ago

Latest

What’s confusing about the Ai Pin is that it most readily feels like it fits in that third device slot, as “the slightly more compact and mobile computer with a twist,” but it primarily seems designed to do the job of the computer that’s hardest to give up — the smartphone. I’ve seen plenty of people wonder why the Ai Pin isn't an accessory to a smartphone, like the Apple Watch. Something that offers another way into information a smartphone can access, but also has its own functionality. There’s a world where an Ai Pin that works like an Apple Watch with GPS and cellular, relying on a smartphone’s connectivity but able to be used on its own, makes more sense and is an easier sell.Inverse, 3d ago
With a strong and established reputation for excellence in academic publishing, Journal of Experimental Biology (JEB) is recognised around the world as a champion of exceptional research. Among our authors, we can count Nobel Laureates and titans in the field, including Hermann Muller, who discovered X-ray damage of DNA (Muller and Dippel, 1926); Archibald Hill – of muscle physiology fame – looking at colour changes in mummichogs (Hill et al., 1935); neurobiologist Andrew Huxley, who investigated the physics underpinning structural colours (Huxley, 1968); Alan Hodgkin and Bernard Katz working on nerve structure and conduction (Hodgkin and Katz, 1949); and, of course, August Krogh, who published his first paper with the journal on the permeability of trout eggs to D2O and H2O in 1937 (Krogh and Ussing, 1937). In the accompanying timeline (Fig. 1), I highlight some of the key papers from the journal's past, many of which were featured in our JEB Classics series, where modern experts revisited the research and discussed its long-term impact. Although some of the ground-breaking discoveries featured in the journal's earlier issues are now ensconced in modern textbooks, others, such as Gray and Hancock's 1955 publication on the propulsion of sea urchin spermatozoa (Gray and Hancock, 1955) and Weiss-Fogh's, 1973 paper on lift production mechanisms (Weis-Fogh, 1973), are still being cited today, contributing intellectually more than 50 years later. This Perspective aims to revisit some of the classic papers that have been published in the journal over the past 100 years to provide a snapshot of key journal breakthroughs and a sense of the fields they inspired.The Company of Biologists, 3d ago
Goal: This project aims to get more grounding into how promising automating alignment research is as a strategy, with respect to both advantages and potential pitfalls, with the OpenAI superalignment plan as a potential blueprint/example. This will be achieved by reviewing, distilling and integrating relevant research from multiple areas/domains, with a particular focus on the science of deep learning and on empirical findings in deep learning and language modelling. This could expand more broadly, such as reviewing and distilling relevant literature from AI governance, multidisciplinary intersections (e.g. neuroscience), relevant prediction markets, and the automation of larger parts of AI risk mitigation research (e.g. AI governance). This could also inform how promising it might be to start more automated alignment/AI risk mitigation projects or to dedicate more resources to existing ones.alignmentforum.org, 3d ago
Figure 1b shows the entire domestic chick egg (Gallus gallus domesticus), we have used the frame of reference of the brain coordinates (front-post-left-right) with respect to the sagittal axis of the brain inside the egg. We have now clarified this point in the caption to avoid any confusion (ll. 84-85). We have also modified the image adding “F” for frontal and “P” for posterior to better exemplify the reference coordinates. Regarding the question about the size of the manganese-positive area relative to the brain size, we would like to provide clarification. MnCl2 diffuses throughout the entire brain tissue, resulting in regional differences primarily influenced by activity-dependent uptake. This uptake is proportional to the time integral of sustained activity within each specific region. Consequently, it is not possible to define a distinct "manganese-positive" area, as the MnCl2 permeates the entire parenchyma of the brain.eLife, 3d ago
One of the most intriguing mysteries in science is the origin of life. Despite extensive research in this area, we are still far from understanding how life has emerged on Earth. One promising hypothesis is the RNA world theory [1–6], inspired by the discovery of ribozymes [7], i.e. RNA molecules capable of enzymatic activity. According to this hypothesis, all processes in early life were carried out by the RNA, which was used both to store information and to catalyze biochemical reactions. In particular, specific ribozymes could have catalyzed the selfreplication of arbitrary RNA sequences, a function currently performed by specialized protein-based enzymes. However, based on the results of the existing experiments [8, 9], such a catalytic function requires rather long and carefully designed RNA sequences, which are highly unlikely to arise spontaneously. In contrast, one of the simplest catalytic activities of ribozymes is their ability to cleave an RNA sequence at a specific site. Indeed, such ribozymes independently evolved in multiple branches of life [10] and have been shown to emerge rapidly and repeatedly from artificial selection [11, 12]. DNA molecules have also been shown to be capable of site-specific cleavage targeting either RNA [13] or DNA sequences [14, 15].elifesciences.org, 3d ago
No experiment I could possibly design today is more valuable than preserving the opportunity to pose a new experiment tomorrow, next year, or in a decade. My cohort of scientists has come up inspired by imagining what it was like for contemporaries of Darwin to encounter and compare global wildlife, or during the modern synthesis, as the invisible internal mechanisms of evolutionary genetics unfurled. Now, we stare down the prospect that, during our turn, we will have to watch the biosphere die. I have peers who set out to study ancient mass extinction events only to find that the conditions that precipitated ancient mass extinction events aptly describe events now. I have contemporaries who set out to discover new species by recording sounds in the rainforest, only to capture an eerie transition toward silence. I've done very little field work and I study hardy, laboratory-tractable species that aren't endangered or picky about where they live, but even I stopped finding butterflies at my best collection site after wildfires. In my 10 years in science, I think I've never been to any research conference, on any topic, without hearing my colleagues interject dire warnings into their presentations – and I've never attended a climate-focused conference. So, the most important research question is ‘will the species I hope to study – and a stable international society that can support research activity as I've known it – survive the next 50 years?' With that in mind, with ‘unlimited’ funding, the best thing I can imagine doing for science is to fight. I think of legal support for climate protesters; cultivating honest communication platforms that bypass corporatized media; criminalizing ecocide; eliminating fossil fuels fast; protecting democracy against regulatory capture; buying out and defending the recommended 30% of Earth's surface as nature reserves; facilitating socially just transitions to safely support humans in the remaining land.The Company of Biologists, 3d ago

Top

This approach provides a unique window into the complexities of the brain, particularly in understanding conditions that affect cognitive and mental health. Professor John Duncan from the MRC CBSU adds, “These artificial brains give us a way to understand the rich and bewildering data we see when the activity of real neurons is recorded in real brains.”...unite.ai, 9d ago
By removing a tiny part of a fly’s exoskeleton on top of its head to expose the brain, the researchers were able to observe the activity of these forgetting neurons in real time. This window into the fly brain revealed that the forgetting neurons were chronically active, said Davis. Perhaps, he hypothesized, forgetting might be the default fate for information, and things are only remembered if another part of the brain judges them to be worthy of keeping and overrides the forgetting mechanism. He acknowledged that this hypothesis may be a bit extreme, and it’s unclear what this judging part of the brain would be, but he hopes to explore this concept in future experiments.Drug Discovery News, 5d ago
Gizem Gumuskaya 33:55 I can go. So first of all, these are not genetically modified. So let me talk about creating new structures from precursor cells. A lot of what has been done in that field, which is general the field of synthetic morphogenesis, has so far relied on insertion of genetic circuits, which in and of itself is a really exciting area, because then we get to test our hypotheses about how form develops in nature in very sort of organized way. For example, like a really good example of that is, Alan Turing had this hypothesis for how certain paths or patterns arise in nature called Turing patterns. He had a mathematical theory about this, but he's not a biologist, so he never really got to prove this. And a few years ago, scientists took Alan Turing's mathematical theorem and basically created a genetic circuit out of that. So genetic circuits are very similar to electrical circuits. Instead of transistors, you just have genes interacting with one another and creating complex Boolean logic. So they encapsulated Turing's theory into the strength of circuit and put it into living cells to bacterial cells. And bacterial cells did indeed create these patterns that are known as training patterns. So without the strength ik circuit approach, we would have no way of testing this. So that's a really versatile and really interesting way to approach. But that dictates the use of exogenous DNA, so that essentially Crescentic modified organisms. So one of the questions we asked is, could we bring the synthetic morphogenesis design of creating new structures with biological cells, without using any genes and into robots, again, is an example of that, we have only changed the environmental parameters and how we grow these I mean, that's five years, we've started from tracheal cells, because we want to make mo tiles spheroids. And, you know, tracheal, cells already know how to build cilia, you don't need an exogenous genes or circuits to teach them how to do it. And by just growing them in different conditions, we're able to steer the entire system towards our target architecture of interest. And that's how we accomplished this kind of synthetic morphology. So that lack of genetic circuitry is makes it is one of the big features that make it inherently safe. Because if we want to create an answer robot from a given patient, we would just take the cells from that patient and build the answer robots that way. And at the end, that answer about would have the exact same DNA as the patient. And when we inject it into the patient, it wouldn't be any different than the existing cells in that patient's body. So this is a big win for potentially preventing any type of inflammation in the body or immune response. So that's our sort of safety gear number one. And number two, is the fact that answer robots after some time on naturally degrade. So even if you just, you know, let them live forever, they don't. And the way they degrade is by becoming individual cells. So in the lab, and let's just by becoming individual cells, so the multicellular and robot will just degrade into individual cells, which can just be then sort of, depending on the tissue that it's inoculated can be expelled from the body through natural bass. So these are the two main safety features that are already built in.newswise.com, 5d ago
The second challenge for the ongoing legislative efforts is the fragmentation. AI systems, much like living organisms, transcend political borders. Attempting to regulate AI through national or regional efforts entails a strong potential for failure, given the likely proliferation capabilities of AI. Major corporations and emerging AI startups outside the EU’s control will persist in creating new technologies, making it nearly impossible to prevent European residents from accessing these advancements. In this light, several stakeholders[4] suggest that any policy and regulatory framework for AI must be established on a global scale. Additionally, Europe’s pursuit of continent-wide regulation poses challenges to remaining competitive in the global AI arena, if the sector enjoys a more relaxed regulatory framework in other parts of the world. Furthermore, Article 6 of the proposed EU Artificial Intelligence Act introduces provisions for ‘high-risk’ AI systems, requiring developers and deployers themselves to ensure safety and transparency. However, the provision’s self-assessment nature raises concerns about its effectiveness.Modern Diplomacy, 20d ago
Focal seizures, on the other hand, happen only in part of the cerebral cortex. Symptoms will depend on the function of the brain area affected by the seizure. If it's a motor region, some muscle twitches might be observed.medicalxpress.com, 27d ago
Alongside these opportunities, AI also poses significant risks, including in those domains of daily life. To that end, we welcome relevant international efforts to examine and address the potential impact of AI systems in existing fora and other relevant initiatives, and the recognition that the protection of human rights, transparency and explainability, fairness, accountability, regulation, safety, appropriate human oversight, ethics, bias mitigation, privacy and data protection needs to be addressed. We also note the potential for unforeseen risks stemming from the capability to manipulate content or generate deceptive content. All of these issues are critically important and we affirm the necessity and urgency of addressing them.lesswrong.com, 26d ago

Latest

Epistemology: Beyond psychological dynamics, some have identified epistemological deficiencies as a root cause for misinformation: issues with how users find and assess information especially online. Some have focused on online search or 'research' (Tripodi, 2018), behaviours, or looked more broadly at verification strategies (Schwarzenegger, 2019; Flintham et al., 2018). Expanding this focus on epistemology to the social level, others have ascribed the problems of misinformation to a broad national shift in the treatment of evidence and facts. Much of this work has drawn implicitly or explicitly on Foucauldian 'regimes of truth' (1980) or Jasanoff's 'civic epistemologies' (2004). The implication is that in recent years, the US has seen a broad shift both in the discourse around and mechanisms of how truth/falsehood is established in society. At the same time, this aligns with the long-recognised tactic by authoritarians to undermine the public's ability to sort truth from falsehoods (Arendt, 1951). Relatedly, many have ascribed the spread of misinformation, at least in part, to a broad reduction in trust in institutions. Public opinion surveys have tracked such a decline in trust across institutions for decades, and now, truth in most institutions is at historic lows (Pew, 2022). This work recognises that trust plays an essential role in public knowledge production: whether that is trusting the government to provide accurate information, trusting scientists to accurately describe their unique access to and understanding of the natural world, or trusting media to accurately and objectively describe the world.Internet Policy Review, 3d ago
Earlier studies showed that a brain region called the hippocampus governs both the formation and retrieval of episode memories. PTSD is associated with structural abnormalities of the hippocampus, mostly a reduction of its volume. Impairments to the processes of the hippocampus are a focal point in studying how PTSD affects the brain.Popular Science, 3d ago
The behavioral responses of monarchs to magnetic cues in our study provides further evidence that monarchs are capable of magnetosensation. Our results also demonstrate that monarchs can derive directional information from the magnetic field, as they respond to the inclination angle of the magnetic field to guide oriented movement and body positioning (Guerra et al., 2014; Wan et al., 2021). In addition, as we showed that monarchs are capable of gravisensation and respond to both gravity and magnetic field cues when together, we now have evidence for a mechanism (as suggested in Wiltschko and Wiltschko, 1972) for how animals can sense up and down to properly interpret the inclination angle of the Earth's magnetic field in 3D space when using inclination angle for directionality during movement. Such a mechanism of using gravity for sensing up and down might also be used by other species that similarly use the inclination angle of the geomagnetic field for oriented movement, such as birds, sea turtles and fish (reviewed in Lohmann et al., 2007). The ability of monarchs to sense and move with respect to gravity provides them with this key piece of information during magnetic compass use; that is, the use of gravity and the direction of the gravitational vector as a key reference point for interpreting inclination angle (Wiltschko and Wiltschko, 1972).The Company of Biologists, 3d ago

Latest

In this study, we investigated the use of antennal movements in olfactory sensing. We show that cockroaches locate and track static and moving odours by shifting the antennae towards the plume centre where local high-frequency movement bouts are carried out. Interestingly, however, long-range scanning sweeps continue throughout, such that the overall sensory range covered is not significantly impacted. Consistent with previous findings, during intermittent pausing bouts (potentially akin to the slow walking movements in this study), cockroaches displayed wide uncorrelated vertical and horizontal movement, presumably favouring the discovery of environmental cues (Okada and Toh, 2004). With odour presentation, cockroaches displayed changes in behaviour in an odour- or valence-dependent manner: enhanced antennal movement and decreased walking speed for attractive odour stimulation (sex-pheromone in Nishiyama et al., 2007, and colony odour here), which are inverted for an aversive odour stimulus (Nishiyama et al., 2007). Our current study did not include highly aversive odours, but the weaker antennal responses (Figs S2B, S3C) and slight increase in walking speed (Figs S1C, S3A) in response to our low valence odour (linalool) nevertheless indicate an overall consistent antennal sampling behaviour (Figs 3, 4Biii,Ciii, 5). Upon odour detection, a general increase in fast movement components was observed, with rapid vertical strokes exhibited most prominently during the stimulus presentation, and increased horizontal sweeps that also continued after stimulus termination. A similar increase in oscillation frequency has recently been reported in bumblebees (Claverie et al., 2023), corresponding to frequencies of optimal odour capture rates (Claverie et al., 2022). Utilising both numerical simulations and particle image velocimetry (PIV) experiments with artificial antennae, Claverie et al. (2022) (see also Su et al., 2019, and Reidenbach et al., 2008) demonstrated that the air flow vortexes generated by antennal oscillations can enhance the transport and adsorption of odour molecules through the sensory pores. In agreement with that, our in vivo visualisations of the flow and odour concentrations around the cockroach antennae provide empirical evidence that these thin appendages create significant flow fluctuations. Additionally, our results of increased movement frequency with odour detection are reminiscent of the antennal behaviour towards tactile stimuli (Okada and Toh, 2006), where an increase in contact frequency occurred with object detection, indicating an increased accuracy of orientation toward the object.The Company of Biologists, 3d ago
A quarter of a century later that summary still applies. Which is not to suggest, however, that science has made no progress. Over the decades observers have gathered ever more convincing evidence of dark energy's existence, and this effort continues to drive a significant part of observational cosmology while inspiring ever more ingenious methods to, if not detect, at least define it. But right from the start—in the first months of 1998—theorists recognized that dark energy presents an existential problem of more immediate urgency than the fate of the universe: the future of physics.Scientific American, 3d ago
Carpentier and Blondin question the physiological importance of human BAT during acute cold exposure, as the amount of BAT is relatively small in comparison with rodents and cold exposure invokes a multi-organ response (e.g., shivering thermogenesis) in which the contribution of BAT may be minor. Moreover, they raised concerns as to whether 18F-FDG uptake truly reflects BAT thermogenesis, particularly in older or diabetic subjects, arguing that glucose uptake and metabolism may not be directly coupled to thermogenesis. As such, they question whether there is sufficient evidence that BAT dysfunction contributes to development of metabolic disease. Substrate preference for BAT thermogenesis has been a topic of discussion. The development of improved stable isotope tracing techniques is now enabling investigators to elegantly trace nutrient fate and identify critical fuels of thermogenesis in adipocytes (12, 13). Emanating from these emerging studies is an appreciation of the flexibility of brown adipocytes with respect to fuel selection and the importance of nutritional state (fed versus fasted) in determining the preferred fuel choice (10). Multiple factors may influence substrate utilization in BAT. For example, mice display a diurnal rhythm of BAT thermogenesis, including rhythmic futile creatine cycling, which is highest during the start of the active/dark period (14). Diurnal BAT activity may be an important factor to consider when studying the therapeutic potential of promoting BAT activity. Other additional experimental factors may need to be considered in the study of BAT thermogenic activity, such as the duration of cold exposure.jci.org, 3d ago
Ribosomes translating membrane proteins are targeted to this translocon complex at the endoplasmic reticulum (ER) membrane, where the nascent transmembrane domains (TMDs) partition into the lipid bilayer and establish their native topology relative to the membrane (Stage I) (28, 30, 41). After translation is complete, membrane proteins fold and assemble (Stage II) in a manner that is coupled to their passage through the secretory pathway to the plasma membrane and/ or other destination organelles (17, 30, 44). Though they are governed by distinct physicochemical constraints, failures in either Stage I or Stage II folding are capable of increasing the proportion of nascent membrane proteins that are retained in the ER and prematurely degraded (17, 44). We therefore expect that epistatic interactions can arise from the cumulative energetic effects of mutations on either of these processes. Given that three-dimensional protein structures are stabilized by similar energetic principles in water and lipid bilayers, mutations that modify the fidelity of Stage II folding energetics should potentially generate long-range epistatic interactions that are comparable to those observed in soluble proteins (17). By comparison, the topological transitions that happen during the early stages of membrane protein synthesis may be coupled to neighboring loops and helices in a manner that can play a decisive role in the formation of the native topology (13, 25, 43). Based on these considerations, we reason that the effects of mutations on each process could create distinct epistatic interactions.elifesciences.org, 3d ago
Unlike urban areas where trauma hospitals are easily accessible, in this part of the country injured patients can be several hours away from help. As a result, patients are more likely to succumb to their injuries before reaching a hospital, according to an analysis of federal data by The Dallas Morning News, in collaboration with medical researchers from the University of Alabama at Birmingham.Each year, medical researchers estimate tens of thousands of Americans bleed to death despite having injuries they could have survived, a reality that trauma physicians have decried as a health crisis. Traumatic injury is the top killer of children and adults under the age of 45, claiming the life of an American about every 3½ minutes. Yet medical specialists argue it receives little federal funding for research that could help improve outcomes compared with other leading causes of death.Nationwide, paramedics often lack the tools they need to treat severe internal bleeding, and patients have sporadic access to lifesaving interventions like blood transfusions before arriving at a hospital. Injured patients routinely bleed out before reaching a doctor, despite scientific advances that make blood transfusions on ambulances possible.For decades, trauma specialists posited that seriously wounded patients should be treated at an equipped hospital within the “golden hour” immediately following their injuries. More recent research from the past several years suggests the critical window is closer to a half-hour for severely bleeding patients, whose risk of dying grows with each minute they don’t receive blood and other crucial treatments.Above-average proportions of people dying of their injuries before they reach a hospital indicate more lives could potentially be saved, researchers say.The News’ analysis found trauma care in the U.S. is starkly inequitable, in that where you live can determine whether you survive. Nationwide, there is unequal access to emergency medical services and trauma hospitals equipped to treat the most severe injuries. The problem is most severe in the more rural West and South.The News used Centers for Disease Control and Prevention mortality statistics to compare the number of prehospital to in-hospital trauma deaths for all U.S. states and most counties from 1999 through 2020. It also mapped the locations of high-level trauma hospitals nationwide and calculated the approximate travel times to them for every part of the U.S.Governing, 3d ago
At the edge where AI is being built into much smaller and less sophisticated systems, the potential pitfalls can be very different. “When AI is on the edge, it is dealing with sensors, and that data is being generated in real time and needs to be processed,” said Sharad Chole, chief scientist at Expedera. “How sensor data comes in, and how quickly an AI NPU can process it changes a lot of things in terms of how much data needs to be buffered and how much bandwidth needs to be used. How does the overall latency look? Our objective is to target the lowest possible latency, so from the input from the sensor to the output that maybe goes into an application processor, or maybe further processing, we’d like to keep that latency as low as possible and make sure that we can process that data in a deterministic fashion.”...Semiconductor Engineering, 4d ago

Latest

In the upcoming year, I foresee that AI tools like ChatGPT and Midjourney will continue to transform how businesses operate and enhance their customer experiences. What really excites me is the potential of new quantum techniques to make these AI models faster and more efficient, ultimately reducing costs and environmental impact. This will make these AI models more accessible and speed up their adoption in the business world.Fast Company, 4d ago
Cell death also occurs in specific areas of the brain, including the hippocampus, that are critical for areas of cognition like memory and spatial navigation. Therapeutic interventions that can preserve cognitive function in AD are therefore of substantial importance, particularly because the incidence of Alzheimer’s Disease diagnoses is expected to grow as a function of the increase in elderly populations.Open Access Government, 4d ago
But while we regulate its harms, we must not take away the benefits of this technology. I wondered what ChatGPT would say about its legacy. So, I asked it to write me a paragraph about it. This is what it came up with: “My legacy lies in the realms of facilitating communication, providing information, and aiding in problem-solving. Since my inception, I have been utilized by individuals and organizations worldwide, contributing to a wide array of discussions and endeavours. While I don’t possess personal experiences or ambitions, my impact is evident in the countless interactions where I’ve assisted users in generating content, learning new concepts, and fostering creative thinking. My legacy is intertwined with the evolving landscape of AI and its applications in enhancing human capabilities and understanding. The true measure of my legacy is reflected in the diverse ways people have harnessed my capabilities to connect, learn, and explore new frontiers in the digital era.”...Sify, 4d ago
While deploying AI solutions, it is important to proceed with caution given their evolving learning capabilities. The CAR strongly believes that there needs to be national oversight for AI applications, particularly as they relate to patient care. Best practices, rules, and regulations are necessary and should be monitored at a federal level. Despite the numerous benefits that AI could bring to patients and healthcare professionals, we must also remain cognizant of the potential risks associated with its application.Hospital News, 4d ago
But in theory, there’s a way to push past this quantum limit. In their study, the researchers also show that by manipulating, or “squeezing,” the states that contribute to quantum noise, the stability of an oscillator could be improved, even past its quantum limit.SciTechDaily, 4d ago
Ayesha Iqbal, IEEE senior member and engineering trainer at the Advanced Manufacturing Training Centre added: "AI has significantly evolved in recent years, with applications in almost every business sector. However, there are some barriers preventing organisations and individuals from adopting AI, such as a lack of skilled individuals, complexity of AI systems, lack of governance, and fear of job replacement. With AI growing more rapidly than ever before, and already being tested and employed in education, healthcare, transportation, finance, data security, and more, it’s high time that the Government, tech leaders, and academia work together to establish standards and regulation for safe and responsible development of AI-based systems. This way, AI can be used to its full potential for the collective benefit of humanity."...electronicspecifier.com, 4d ago

Latest

...“Punctual literature,” as Heffernan calls it, is a narrow category, especially when it comes to World War II, for practical reasons: it isn’t easy to write and publish while being bombed. To fortify his argument Heffernan further narrows his definition of “punctual,” limiting his survey primarily to fiction, poetry, and plays set or composed or published in 1939 (which happens to be, he gallantly declines to mention, the year of his birth) “and one or at most two of the years that followed.” Virginia Woolf’s Between the Acts, Patrick Hamilton’s Hangover Square, and Evelyn Waugh’s Put Out More Flags are novels about historical events, but they’re not historical fiction, strictly speaking, because they were written in the early years of the war, before the conclusion was known—before the chaos of those years could be sealed and wrapped and ribboned in a tidy narrative. “The uncertainty of being in medias res,” writes Heffernan, “is precisely what punctual literature aims to represent.” Ignorance of the war’s outcome does not count as a deficiency of this literature, as it might to a historian, but as an advantage.The New York Review of Books, 4d ago
For example, it is conceivable that the changes in brain water associated with obesity could represent an effect of obesity on the brain, that is WHR→ISOVF, whereas the obesity-related changes in neurite density could represent an effect of the brain on obesity, that is ICVF→WHR. Such a bi-directional mechanistic model of the relationships between obesity and the brain seems somewhat plausible. Obesity is usually caused by changes in eating behaviour and physical activity, which are controlled by brain systems enriched for opioid, dopamine and cannabinoid receptor-mediated signalling. So changes in the brain, indexed by neurite density, could conceivably cause adipogenic eating behaviours and thus obesity. Obesity in turn causes a pro-inflammatory state systemically and blood concentrations of CRP, IL-6 and other cytokines have previously been associated with changed (increased) micro-structural MRI metrics of free water (Kitzbichler et al., 2021). So inflammation could potentially mediate effects of obesity on the brain tissue water content (see also Turkheimer et al., 2022). Our finding that the CRP-WHR map correlation is significantly stronger for the ISOVF maps than the ICVF maps would be consistent with this hypothesis.eLife, 4d ago
But other nudes, gentler, more sensitive, and in particular the series Couchers ou des Levers (Going to Bed or Getting Up), show once again just to what extent Degas was able to do one thing and its opposite. These women, as if glimpsed through a keyhole,19 chastely wearing their nightcaps, are more evocative of seventeenth-century Holland than of mocking or erotic views of lowlife Paris. Sometimes, Degas would pass from one world to another with the same image as the point of departure. For instance, the first proof of Woman in a Bathtub shows an ugly woman in squalid surroundings while the second one, overlaid in pastel, gave him a chance to retouch the face, to decorate the bathroom walls, and to create a cozy atmosphere. He undertook a comparable transformation in his treatment of the second proof of Woman Going to Bed. In the first, the woman is scarcely sketched out and the decor is nondescript. In the second, the body is admirably drawn, the carpet has been created by the artist’s fingerprints, and the far wall and the bedclothes have real substance. These continual alterations become even more surprising in Degas’s landscapes.The New York Review of Books, 4d ago

Top

...“In a tech landscape abuzz with the potential of generative AI, understanding its power and pitfalls is a must. Organizations across every vertical are looking into how to leverage this technology to get ahead or simply ensure they can keep up with the latest and greatest advancements. Rushing implementation and forgoing the necessary learning process isn’t going to be worth the investment. A thoughtful, concerted approach that is rooted in data is essential for generative AI. To truly reap the advantages of AI investments, organizations must take a close look at their data strategy and ensure they are prepared for success. If using it to solve specific business problems is the goal, it’s key to consider how the training process for those models is done and examine the underlying foundation of data that you’re supplying in order to get the result you need.insideBIGDATA, 11d ago
The improved resolution will help neuroscientists probe the neuronal circuits in different regions of the brain’s neocortex and allow researchers to track signals propagating from one area of the cortex to another as we think and reason, and perhaps discover underlying causes of developmental disorders. This could lead to better ways of diagnosing brain disorders, perhaps by identifying new biomarkers that would allow diagnosis of mental disorders earlier or, more specifically, in order to choose the best therapy.SciTechDaily, 7d ago
The participants had their brains scanned with a structural MRI to look for any underlying differences in brain anatomy between the groups, specifically looking at gray matter volumes and the thickness of the cortex. They also had a functional MRI to map brain activity detected by changes in blood flow, which indicates areas of the brain that are more active during specific tasks or at rest.Inverse, 25d ago
For example, one of the studies -- research carried out in the 1980s by Professor Michael Merzenich at University of California, San Francisco -- looked at what happens when a hand loses a finger. The hand has a particular representation in the brain, with each finger appearing to map onto a specific brain region. Remove the forefinger, and the area of the brain previously allocated to this finger is reallocated to processing signals from neighbouring fingers, argued Merzenich -- in other words, the brain has rewired itself in response to changes in sensory input.ScienceDaily, 13d ago
For example, one of the studies – research carried out in the 1980s by Professor Michael Merzenich at University of California, San Francisco – looked at what happens when a hand loses a finger. The hand has a particular representation in the brain, with each finger appearing to map onto a specific brain region. Remove the forefinger, and the area of the brain previously allocated to this finger is reallocated to processing signals from neighbouring fingers, argued Merzenich – in other words, the brain has rewired itself in response to changes in sensory input.SciTechDaily, 10d ago
So let’s start scanning! Let’s assume we’ve solved scanning with one of these techniques, or something else entirely. What’s important is that now we have the data we need. Now it’s time to turn our scan into a computer emulation. We’ll first need to take the raw brainscan data and convert it to a form we can use, perhaps a big list of neurons and synapses, and an accurate model of how each connection behaves. Given that there are 100 trillion synapses in the brain, there's no way we can do this manually. It will have to be automated one way or another - and it's a safe bet that AI would probably be involved. We won’t necessarily need human-level AI - specialized systems based on today’s neural nets could be able to do the job. Suppose, for example, that the raw data from our brain scans will be a colossal number of similar images. Then, neural nets could help process those images to create 3-dimensional maps of the brain regions we’ve scanned.lesswrong.com, 21d ago

Latest

The adult watcher of Prehistoric Planet might also find herself nostalgic for a time before the climate change “debates,” when science seemed to have greater authority and the projection of the world it offered suffered less from bargaining and predatory skepticism. A short presentation (Prehistoric Planet: Uncovered) appears as a coda to each episode, scrutinizing an aspect of the preceding show: “Was Pachycephalosaur Really a Headbutter?” “How Fast Was a Mosasaur?” But when Alex rejoined me for one of these, he was less curious about the factual plunges into paleontological research than about the show’s digitally enhanced Cretaceous. As was I. If there was ambiguity about the feats of world-building I’d been drawn into, I didn’t want to hear about it. Let paleontology be an uncontentious science. Let these visions of the planet be uniting, not divisive.The New York Review of Books, 4d ago
In other words, bodily capacities are effectuated within certain habitual dispositions – and what shapes these habitual dispositions, especially in the villages we talk about? It is the gendered division of labour, it is the structures of dwelling and the social and spatial organization of everyday life, and it is the geographical and cultural configurations of patriarchy. In the case of the East Black Sea, all these factors translate into what I talk about a lot in the book – that agricultural work is seen as women’s work in the region, and hence, it is the women who spent a lot of time outside, within the dramatic landscape of the region, in the tea and hazelnut fields or sometimes with cattle and goats, always by a river, always with a river – which enables women to establish a very strong, very intimate relationship with the river through their bodily senses and affects. And those bodily senses and affects also function as the basis of body memory, as I discuss in the book.UC Press Blog, 4d ago
The U.S. and China both realize the power of AI and how it can enhance capabilities, such as military capabilities. Yet, with such a technology comes the responsibility determine ethical frameworks, establish robust regulatory measures, and engage in international collaboration to ensure the judicious and ethical deployment of AI for the collective benefit of societies globally. The world has evolved, nations have continually competed, and militaries continue to search for the most robust capabilities. AI is not just a tool that simulates human intelligence but could potentially transform into a weapon system.Modern Diplomacy, 4d ago
Based on his calculations, Tipler determined that a civilization limited to a modest fraction of the speed of light (10%) could accomplish this within just 650,000 years—long before life and human civilization arose on Earth. Given the fact that no evidence of any civilization existed (what Hart called "Fact A") means that there were no ETCs and humanity was alone in the universe. In 1980, physicist and cosmologist Frank Tipler took things further in his paper "Extraterrestrial Intelligent Beings Do Not Exist," where he employed refined calculations and the Copernican Principle.phys.org, 4d ago
The release last year of OpenAI’s flagship ChatGPT engine—which quickly became one of the most popular software launches of all time—seems to have crystallized divisions within the company. As Karen Hao and Charlie Warzel wrote in The Atlantic last week, the launch “sent OpenAI in polar-opposite directions, widening and worsening the already present ideological rifts.” (In a 2019 email to staff, Altman referred to “tribes” at the company.) A source told Hao and Warzel that, once it became obvious how quickly ChatGPT was growing, OpenAI “could no longer make a case for being an idealistic research lab,” because “there were customers looking to be served here and now.” Within a matter of months, OpenAI had two million users, including many Fortune 500 companies, and had signed an investment deal with Microsoft for thirteen billion dollars in funding. Just before he was ousted, Altman was said to be trying to raise funds to start a computer chip company that could supply OpenAI’s insatiable demand for computing power.Columbia Journalism Review, 4d ago
If the recent tussle over the firing and re-hiring of OpenAI CEO Sam Altman has taught us anything, it’s that there will always be an inherent tension between what AI promises – its inherent value – and the risks of a technology potentially “too disruptive for its own good”. Over the next year we can expect more OpenAI style fall-outs involving native AI companies, regulators, governments and other stakeholders as society grapples with the implications of what is essentially a live experiment. Companies engaging at any level with generative AI should expect and even encourage debate around how this dichotomy can be handled.Compare the Cloud, 5d ago

Top

However, the effects of anesthesia (and brain slicing) on various parts of the central nervous system have been a topic of considerable attention (Hao et al., 2020). For example, cognitive behaviors, like attention and motivational state, which have a large impact on neural activity, are absent in anesthetized animals (Hembrook-Short et al., 2017; Rossi et al., 2013). But neurons in early sensory systems, such as the retina, already process much of the neural code before it is even transmitted to the brain visual centers. These early sensory systems thus receive limited feedback from the brain and are thought to be less affected by anesthesia (Gastinger et al., 2006). Now, in eLife, Tom Boissonnet, Matteo Tripodi and Hiroki Asari at the EMBL Rome and the Université Grenoble Alpes report new findings that challenge this assumption (Boissonnet et al., 2023).eLife, 24d ago
Our study is thus relevant to understanding of constraints on the evolutionary refinement of physiology and life history of metazoans. Complex multicellularity crucially depends on the ability of the genome to express its genes differently in different cell types and life stages. The existence of specialized cells and organs that express greatly different yet highly coordinated and functional metabolic phenotypes from the same genome testifies to the power of regulatory evolution. On the other hand, there has been increased recognition that the ability of evolution to independently shape phenotypes of different life stages and sexes may be significantly constrained. Such constraints are expected to emerge from the complexity of gene regulatory and metabolic networks (Wagner, 2011; Sorrells et al., 2015; Schaerli et al., 2018). One manifestation of such constraints is ‘intralocus sexual conflict’ (sexually antagonistic pleiotropy), whereby simultaneous optimization of female and male phenotypes is hindered by constraints on independent evolution of gene expression in the two sexes (Rice, 1984; Pischedda and Chippindale, 2006; Hollis et al., 2014; Veltsos et al., 2017). Similarly, the developmental theory of aging postulates that gene expression and metabolism are optimized for maximizing performance at a young age and fail to adjust in later age in ways that could improve reproductive lifespan or healthspan (de Magalhães, 2012; Gems and Partridge, 2013), an idea increasingly supported by experimental data (Carlsson et al., 2021). This apparent metabolic inertia of aging individuals might be explained by selection at old age being weak (Medawar, 1952; Hamilton, 1966; Partridge and Barton, 1993). However, our results suggest similar evolutionary constraints linking the metabolism of juveniles and young adults in their reproductive prime, before the age-related decline in the strength of natural selection sets in Hamilton, 1966. Such constraints would hinder evolutionary optimization of juvenile and adult gene expression and metabolism if optima differ between the stages (Collet and Fellous, 2019).eLife, 24d ago
But how accurate is this portrayal of the brain's adaptive abilities to reorganize? Are we truly able to tap into reserves of unused brain potential following an injury, or have these captivating stories led to a misunderstanding of the brain's true plastic nature? In a paper we wrote for the journal eLife, we delved into the heart of these questions, analyzing classical studies and reevaluating long-held beliefs about cortical reorganization and neuroplasticity. What we found offers a compelling new perspective on how the brain adapts to change and challenges some of the popularized notions about its flexible capacity for recovery.livescience.com, 9d ago

Latest

And these are technologies that were lauded as overwhelmingly positive, and considered at worst entirely benign. Are we better off as a world and as a society because of social media? In some ways, yes. In others, definitely not. The point isn’t to say “social media bad” or “social media good;” it is to say that there have been absolutely enormous, wide-reaching, and almost entirely unforeseen negative consequences from platforms that aimed to do nothing more than let you share your photos or short thoughts with an opting-in audience of friends and acquaintances. AI developers aim to create entities that possess superhuman intelligence and to remake just about every aspect of our lives, from how we work to how we communicate to how we live (and if we live).Ms. Magazine, 5d ago
...“However, while generative AI-powered LLMs are making life easier in numerous ways, we need to be acutely aware of their limitations. For a start, they’re not accurate: GPT-4 Turbo has the most up-to-date data since its inception, but still only contains world knowledge up to April 2023. These systems also hallucinate and have a clear tendency to deliver biased responses. The real concern with ChatGPT is the way these LLMs are presented. They give a ‘human-like’ interaction which inclines us to trust them more than we should. To stay safe navigating these models, we need to be much more skeptical with the data we are given. Employees need in-depth training to keep them up to date with the security risks posed by generative AI and also what its limitations are.”...TechRound, 5d ago
Terrence Malick’s adaptation of James Jones’s 1962 novel based on his World War II experiences fighting in the Guadalcanal campaign changed shape significantly as it made its way to the screen. Malick’s first film in 20 years, The Thin Red Line attracted the attention of established and rising stars alike, some of whom saw their roles reduced, or even deleted, from the final cut. Somewhere there’s an alternate version of the film in which Bill Pullman, Mickey Rourke, and Lukas Haas appear and Adrien Brody plays a key role rather than popping up for a few minutes of screen time. Malick’s editors, in an interview included in the Criterion Collection’s editions of the film, offer the best explanation for his decision-making. Malick cut the film not to service the plot but to make room for the film’s voice-overs. Paired with stunning images of war in the Pacific, they provide lyrical reflections on the characters’ wartime experiences and the loss of innocence that comes with those experiences. Malick returned from his moviemaking absence in full command of his signature ability to capture wonder, but in depicting a kind of hell on earth, he uses that ability to disorienting effect. Here, war spoils all it touches, from those who partake in it to those swept up in it to the land itself. To Malick, it’s an act of awful defiance against creation.Vulture, 5d ago
Artificial intelligence has revolutionized tourist decision-making by shifting the focus from price considerations to personalized alternatives. Tourists can now choose destinations, places, and activities that best suit their preferences, thanks to AI’s implementation of personalization techniques and recommender systems. These systems leverage the vast quantity of information available on the internet, including User-Generated Content (UGC), to provide more tailored and informed experiences. Travel assistants that leverage advancements in artificial intelligence, mobile devices, natural language processing, and speech recognition have become increasingly popular. These applications are designed to cater to user preferences, interests, and availability, offering on-demand or autonomous suggestions that proactively anticipate their needsvand they enhance the travel experience through personalized and intuitive assistance. These systems leverage the vast quantity of information available on the internet, including User-Generated Content (UGC), to provide more tailored and informed experiences. ServiceNow leverages generative AI to provide relevant, direct and conversational responses, seamlessly connecting interactions to digital workflows across the Now Platform. For example, when users inquire through Now Assist for Virtual Agent, generative AI quickly provides concise answers, supplying information such as internal codes for product and engineering teams, product media, document links, or relevant knowledge base article summaries. This ensures accurate conversations across departments and systems, improving productivity, boosting self-solve rates, and expediting issue resolution within ServiceNow. In today’s technology-driven era, the increasing AI footprint in the hospitality industry is a positive development.DATAQUEST, 5d ago
In recent years, the creation of science fiction micro-short dramas has developed rapidly. According to incomplete statistics, there are 149 science fiction micro-short dramas with 3,100 episodes approved for planning and registration in 2022, and 13 science fiction micro-short dramas with 250 episodes approved for online registration. This number is expected to further increase in 2023. However, while the quantity of science fiction micro-short dramas has increased, the quality still needs to be further improved. There are very few works that have good reputation and influence in the industry. Some works secretly change the concept, cloaked in science fiction themes, and tell fantasy, fictional, and time-travel stories. The plots cannot withstand scrutiny and the settings are inconsistent with common sense. Some works lack imagination, rigorous scientific spirit and serious creative attitude, and only use science fiction as an eye-catching background or element. In order to show off their skills, some works construct overly complex worldviews such as parallel worlds and wormholes in a short space of time, overloading the plot with information, causing confusion in story time and space, and confusion between reality and virtuality. Some works over-emphasize strong plots and dramatic reversals, leading to confusing narratives, jumpy thinking, and illogical logic, leaving viewers at a loss. In other works, the special effects and props are crude and inferior, making the science fiction scenes full of plastic texture, making it difficult for the audience to enter the story situation. All these have been criticized by the audience, making it difficult for science fiction micro-short dramas to break through the inherent circle and attract the attention of the audience in a broader social scope.Archyde, 5d ago
Where the drug had its effect was also a factor, monitored in this study using fMRI imaging. These scans showed that the salience network was only activated by intravenous injection of the drug; oral administration did not activate this system. So, the fast rise of DA levels seen after injection of the drug was associated with increased activity in a different part of the brain. This effect was consistently seen in all 20 participants in the study. The increased risk of addiction that accompanies injection directly into the bloodstream may have to do with activation of this salience network and how we direct our attention. The authors suggest that finding a way to inhibit the salience network might lead to new therapies against drug addiction.Psychology Today, 5d ago

Top

The hand has a particular representation in the brain, with each finger appearing to map onto a specific brain region. Remove the forefinger, and the area of the brain previously allocated to this finger is reallocated to processing signals from neighboring fingers, argued Merzenich—in other words, the brain has rewired itself in response to changes in sensory input.medicalxpress.com, 12d ago
One of the great mysteries of modern physics is how to reconcile quantum mechanics with the general theory of relativity. The prevailing assumption is that the gravitational field should somehow be quantised, though a number of alternative approaches exist and the fundamental nature of gravity still remains an open question. In the last few years, however, a potential route to resolving this issue has emerged from the field of quantum information. The idea is that certain types of correlations – for example, entanglement – cannot be created between two distinct subsystems if only local (quantum) operations and classical communication (LOCC) are allowed. This suggests that detecting gravity mediated entanglement between two macroscopic scale masses would indicate that the interaction is either quantised or that gravity acts non-locally in the macroscopic limit.CoinGenius, 26d ago
Rubino notes that at present, the only way to confirm that someone is in the early stages of the disease is to use biomarkers that are assessed by imaging and lumbar puncture—expensive, invasive technologies that are not widely available. This is why there is significant interest in identifying reliable blood biomarkers as an objective measure for screening more patients and gaining insights into what’s going on in the brain much sooner.GEN - Genetic Engineering and Biotechnology News, 19d ago
...“Generative AI has ushered in excitement, creativity, and heightened investment, redefining the boundaries of what’s possible with AI-driven innovations. Combining analytical AI with the functionality of generative AI has companies dreaming of streamlined processes and customer-facing applications that will reduce the need to rely on humans and yet, early adopters of an ‘All AI’ customer service strategy are facing a degradation in service quality, not an improvement. With its ability to ‘hallucinate’ data, inherent biases from training, and the opaque nature of its decision-making, we tread on uncertain grounds. In the customer service industry, a training adage is “don’t practice on customers” referring to the concept of fully training an agent – and yet with AI we are allowing it to ‘practice’ with customers creating negative outcomes.insideBIGDATA, 23d ago
..."This indicates that during different forms of unconsciousness distinct parts of the brain are involved in different ways. Our findings in turn imply that going from unconscious to conscious may use different mechanisms depending on the nature of the unconscious state."...medicalxpress.com, 6d ago
What is the mechanism that allows our brains to incorporate new information about the world, and form memories? New work by a team of neuroscientists led by Dr Tomás Ryan from Trinity College Dublin shows that learning occurs through the continuous formation of new connectivity patterns between specific engram cells in different regions of the brain.ScienceDaily, 10d ago

Latest

This work showed that the thalamus, involved in processing sensitivity and sensory data, was the first structure to be impacted by multiple sclerosis. The putamen, which plays a role in regulating movement and learning, generally starts to deteriorate some four years later. As for the brain stem, which notably regulates heart rate and respiration, it was affected around nine years after the thalamus. In other words, the results obtained by Coupé and his colleagues have shown that several brain structures clearly suffered damage well before the appearance of the first symptoms of multiple sclerosis, which on average were detected more than a decade after the initial signs of neurodegeneration.CNRS News, 5d ago
Moreover, Dr Olivier Cexus from the University of Surrey and formerly at A*STAR, progressively deciphered the complex molecular interactions within the brain organoids using proteomic and lipidomic analysis. This provided valuable insights into the metabolic cross-talks involved in brain development and potential implications for diseases.ScienceDaily, 5d ago
The sex difference in dormancy phenology observed in endotherms and ectotherms may be a widespread consequence of the trade-off between the benefits of being active for reproduction and the benefits of dormancy for survival (viz., the life-history hypothesis). Other non-exclusive hypotheses have also been proposed (Morbey and Ydenberg 2001) and further studies are needed to test them. Energy constraints explain a part of dormancy phenology in both endotherms and ectotherms (Wilsterman et al. 2021), but a large body of evidence from our study shows some independence of energy balance at the specific times of emergence and immergence into hibernation. Thus, we expect that dormancy phenology will exhibit multiple evolutionary causes, especially when many species are studied and compared. The occurance of dormancy at high altitude and latitude where few or no energy resources are available over part of the year appears to be a support for the energy limitation hypothesis (Ruf et al. 2012), although this hypothesis could yet be of limited importance in explaining the phenology of the transition from dormancy to activity and vice-versa. Dormancy in energetically benign periods, but unfavorable for reproduction, may be more widespread than previously thought. Such research highlights the opportunities of studying dormancy across a broad spectrum of species (Wilsterman et al. 2021).elifesciences.org, 5d ago

Latest

In recent years, there has been debate about the effectiveness of treatments from different fields, such as neurostimulation, neurofeedback, brain training, and pharmacotherapy. This debate has been fuelled by contradictory and nuanced experimental findings. Notably, the effectiveness of a given treatment is commonly evaluated by comparing the effect of the active treatment versus the placebo on human health and/or behaviour. However, this approach neglects the individual’s subjective experience of the type of treatment s/he received in establishing treatment efficacy. Here, we show that individual differences in subjective treatment—the thought of receiving the active or placebo condition during an experiment—can explain variability in outcomes better than the actual treatment. We analysed four independent datasets (N=387 participants), including clinical patients and healthy adults from different age groups who were exposed to different neurostimulation treatments (transcranial magnetic stimulation: Study 1 & 2; transcranial direct current stimulation: Study 3 & 4). Our findings show that the inclusion of subjective treatment can provide a better model fit, either alone or in interaction with objective treatment (defined as the condition to which participants are assigned in the experiment). These results demonstrate the significant contribution of subjective experience in explaining the variability of clinical, cognitive and behavioural outcomes. We advocate for existing and future studies in clinical and non-clinical research to start accounting for participants’ subjective beliefs and their interplay with objective treatment when assessing the efficacy of treatments. This approach will be crucial in providing a more accurate estimation of the treatment effect and its source, allowing the development of effective and reproducible interventions.elifesciences.org, 5d ago
Wieloch and his team hope that the mGluR5-blocking drugs known as negative allosteric modulators (NAM) will become the first ever treatment to restore neural circuitry and reverse sensorimotor deficits in human stroke patients. Others in the field view the study as a significant step in that direction. "When I saw the work in this paper, I was excited because the idea is very promising and has a lot of logic and sense behind it," said Joshua Siegel, a neuropsychopharmacologist at Washington University School of Medicine who was not involved in the study but has previously collaborated with study coauthor Adam Bauer, a neuroscientist at Washington University in St. Louis. "There's really nothing that exists on the market that's in this category of 'here's something you can take temporarily after a stroke to accelerate brain recovery.'"...Drug Discovery News, 5d ago
Existing reviews focus on university and college populations (and are therefore not representative of all adolescents); assess social media under the broad scope of digital media and internet use; do not assess risk of bias; and examine few health risk behaviours (ie, substance use and sexual risk behaviour).203233343536 Differential effects by socioeconomic position, specifically whether more disadvantaged groups are more susceptible to harm from social media, consequently resulting in a widening of health inequalities, and those between high and low middle income countries have also not been explored.23373839 Prior research investigating social media’s effect on adolescent mental health suggests age and sex differences, in which greater negative effects exist for female and younger adolescents (compared with male and older adolescents). However, these potential differences are yet to be examined in relation to health risk behaviours.4041 Vannucci and colleagues explored the association between social media and adolescent substance use and risky sexual behaviour.42 The review’s synthesis of electronic media use (defined as electronic media with a direct component involving social interactions with others (2022 personal communication with A Vannucci)) with social media and reliance on pooled correlations inhibits any explicit conclusions about the size of associations resulting from social media use specifically. Due to the high risk of confounding and reverse causation in studies in this area (which largely rely on observational data), assessment of the quality of evidence is important—an area that has been limited in other reviews.3242...The BMJ, 5d ago
The increase in OKR gain could be seen as a substitution for the decrease in the VOR. However, even after VOR recovery, the optimal integration of OKR and VOR (as predicted by our MODEL) led to a degraded combined gaze response (CGR) with respect to SHAM mice. Even worse, the measured CGR was inferior to the predicted CGR (Figure 6B). This observation suggests that the integration of visual and vestibular signals during CGR is more than a mere summation of the gain and phase of the two unimodal reflexes, but is also affected by other factors. In fact, a subset of the IDPN individuals showed severely degraded bimodal responses, so that their combination of VOR and OKR is not only sub-optimal but also less effective than the unimodal (OKR) reflex. A sweep-based analysis suggested that in these individuals, the VOR unimodal responses were not reliable, i.e the low reproducibility indicates that the same stimuli are unfaithfully encoded into eye movements. We interpret this low reproducibility as a sign of noisiness within the VOR pathway that would not only preclude the optimal integration of both sensory signals, but also disturb the use of retinal information to stabilize the gaze. According to statistical optimality theories, as the Maximum Likelihood principle, the decrease in VOR reliability should lead to a reduction in its relative sensory weight. This filtering-out of a degraded signal has been shown during visuo-vestibular integration for monkey heading perception (Fetsch et al., 2010), or for human object discrimination using visual and haptic senses (Ernst and Banks, 2002).Our results suggest that the gaze stabilizing system is not able to optimally adapt to the degradation by filtering-out vestibular signals during combined visuo-vestibular combination.eLife, 5d ago
Once a hypothesised mapping between sensory inputs and behavioural responses has been established, experimental tests are needed to investigate real-life receiver responses and collective action. Manipulations might involve the introduction of artificial cues or signals into a collective system, for example, via audio playback experiments, and presentation of visual or chemical stimuli. The use of robotics in multimodal communication studies has been extensive (Gardner et al., 2021; Patricelli et al., 2007) as it enables individual unimodal components of signals to be presented to receivers in isolation, and then combined with components in other modalities, to investigate the influence of signals both separately and in combination (e.g. Swain et al., 2012). These studies have primarily focused on bimodal signals, and there is a need to increase the number of modalities investigated to more fully describe communication (Higham and Hebets, 2013). However, the power of animal–robot interactions is likely as yet unrealised, in sensory-interactions and information transfer. Only by developing our understanding of the interaction between umwelt and collective behaviour may we advance the use of robotics in collective behaviour studies (Butail et al., 2014; Datteri, 2021; Swain et al., 2012). A further issue in sensory manipulation experiments is that some multimodal signals are ‘fixed’, in that one component of the signal cannot be expressed without the other (e.g. a frog croak that cannot be made without simultaneous inflation of the throat sac), whereas others are ‘free’, with different components of a multimodal display being expressed independently (e.g. visual and vocal components of a bird of paradise display). Depending on the system, it may be easier to present individual unimodal components of a multimodal signal where it is a free signal, than where it is fixed or interconnected.eLife, 5d ago
AI has been a trending topic in technology for years, but nothing has fueled interest like the recent explosive emergence of generative AI. With many nascent tech trends, cybersecurity is a top area of opportunity as well as concern, and this is no less true with AI. The US National Security Agency (NSA) recently created an entity to oversee development and integration of AI capabilities in US national security systems. AI was a central focus of this year’s RSA Conference. It was also the theme of the opening keynote at Black Hat, where the AI Cyber Challenge, a Defense Advanced Research Projects Agency (DARPA) initiative launched by the Biden-Harris administration, was announced. That same week, DEF CON hosted the largest public "red teaming" (penetration testing) exercise against AI models to date. While these initiatives may sound like efforts to compromise generative AI, they are just the opposite. Technology has long benefited from the efforts of informed security researchers to identify and resolve vulnerabilities and exposures. These efforts represent ways to focus the security community on generative AI to help match its pace of innovation, improve risk mitigation, and foster awareness of concerns that require resolution.spglobal.com, 5d ago

Latest

There’s also that little moment with Connor and Willa where he essentially says, “Are we going to cancel this wedding or not?” and they proceed to have a very honest, tough conversation. Maybe the only one they have on the series! The show is a lot about lies and truth, right? There’s a lot of lying, a lot of obfuscation, deception, faking things, representing a set of facts in a certain way to your advantage. One of the tragedies of the family is how contingent and strategized all the relationships have become. It’s second nature to them to see things at six different levels at once: a financial level, a business-future level, a media level, a how-it-would-be-seen-by-people-on-the-outside level, and also how it would be seen by their father, and how it would be seen by their kids. They naturally “PR” themselves. Therefore, when you get moments of people telling us all the most cleaving versions of the truth — a truth that is not self-serving in any way, like Shiv in that other scene — when you’ve just got the truth, it hits. You go, “Oh right — there’s no reason for that person to say that, other than that is the truth.” And because it’s so rare on Succession, I really loved writing these moments.Vulture, 5d ago
But to Bopp and his allies, new information has emerged: testing for death of the “whole brain, including the brain stem”, as stated in the UDDA, is not (and never has been) consistently conducted throughout the country. And cases like that of McMath have shown that other brain functions not addressed by existing testing, such as those of the hypothalamus and pituitary, may continue after the death of the rest of the brain.the Guardian, 5d ago
Based on his calculations, Tipler determined that a civilization limited to a modest fraction of the speed of light (10%) could accomplish this within just 650,000 years – long before life and human civilization arose on Earth. Given the fact that no evidence of any civilization existed (what Hart called “Fact A”) means that there were no ETCs and humanity was alone in the Universe. In 1980, physicist and cosmologist Frank Tipler took things further in his paper “Extraterrestrial Intelligent Beings Do Not Exist,” where he employed refined calculations and the Copernican Principle.Universe Today, 5d ago
Since the 3Rs proposal, about 65 years ago, to “reduce, replace, and refine” animal use in the framework of the performance of more humane animal studies (Russell and Burch, 1959), a tremendous effort has been devoted to this goal with rather limited success when it comes to the complexities of studying the brain. Complete replacement of animals may not yet be possible but a reduction based on better management of animals already sacrificed or to be sacrificed is within reach. For unviability of complete replacement take for instance electrophysiological studies.Open Access Government, 6d ago
No one who has ever retraced the steps of a geometric proof can deny the pleasures Fisher reconstructs with such eloquence and insight in his brief history of scientific explanations of the rainbow. And these pleasures undoubtedly involve surprise: logic may tell us that the conclusion of every proof lies nestled within its premises, like the infinite generations of humanity preformationists thought were nestled in the womb of Eve, yet psychology often responds to the dénouement of a demonstration as if it were the rabbit pulled from the magician’s hat. But are these the pleasures of wonder? Fisher usually writes with precision, sharpening the edges of perceptions and ideas. Here, however, he seems to conflate the pleasures of discovery (and channelled discovery at that) with those of wonder. Wonder is at its strongest when it bursts the bounds of expectation and possibility. The surprises of the geometric proof pale in comparison with those of an aurora borealis or conjoined twins, and for the very reasons that make mathematics so enthralling. The rules for what can be used (ruler and compass only) and assumed (these axioms and postulates and no others) are stipulated at the outset. Wonder in contrast happens when rules are broken, not when they are cunningly followed. Why then blur the line between these two distinct kinds of pleasure? Fisher insists on the pleasurable side of wonder, and further claims that pleasure has its prerequisites. His preferred kind of wonder, which he calls Cartesian wonder, requires a lawful and secure world in which eruptions of the extraordinary inspire curiosity, not terror. He is willing to exclude a great many of wonder’s time-honoured companions and objects – the sublime, miracles, magic, monsters, the Wunderkammer – in order to keep the fearsome side at bay. ‘Wonder and hospitality, in Hamlet’s phrase, rely on the harmlessness of the world, in most of the unexpected ways we find it.’ This is the mild wonder of the tamed world, and only if it is taken as the paradigm of all wonder do the regulated surprises of the geometric proof appear as its close relations. It is revealing that Fisher takes the contemplative smile worn by statues of Greek gods, rather than the open-mouthed, open-eyed receptivity of 17th-century illustrations of the Cartesian passions, to be the characteristic expression of wonder.London Review of Books, 6d ago
Multiple childhood brain tumors, like cortical gliomas, arise from the cortex, the outer layer of the largest part of the brain and the brain’s most expanded structure. Currently, around six in ten children are still alive five years after they were diagnosed with a malignant tumor of the central nervous system. Research into a better understanding of how brain tumors arise and develop could help researchers in finding possible targets for treatment.SciTechDaily, 6d ago

Latest

At the end of The Hedgehog and the Fox Berlin concluded that the tragedy of Tolstoy’s life was that he was torn between these two poles: being a fox in his incomparable attention to the innumerable details of Russian history and society, but a hedgehog in his desire to commit himself to an overarching ideal—to the simple, all-enveloping religious faith of the Russian peasantry; but that it was in this tension that lay the roots of his genius. Much the same thing can be said of Berlin: his intellect and spirit were torn between his ultimate commitment to liberal pluralism, on one hand; and his intuitive grasp of the totalising worldview of Romanticism, on the other. As with Tolstoy, it was this tension that generated Berlin’s unprecedented scholarly insights and rhetorical power.Quadrant Online -, 6d ago
Which brings us to the last man on our slide, no pun intended for any of you Marxists out there, Mao Zedong. He was a student during the revolution; a huge reader, he spent a lot of time during the late 1910s drinking in the classical texts of western liberalism and experimenting with different ideas. By the early 1920s he has experience in secret underground societies and the rudiments of revolutionary activities, organizing, et cetera; and it is at this point that he has fallen in with the Chinese communists. He was a central early member of the Chinese Communist Party, heading one of the branches. He had some peculiar ideas, such as the revolutionary potential of the peasantry, which orthodox Marxists found ridiculous. He also embraced collaboration with the bourgeois revolutionary forces represented by the KMT, at least whenever they were willing to collaborate with him. In fact he even held positions in the KMT in the mid-1920s before Chiang’s purge. Unlike many of his early, and frankly, rival comrades, like Li Lisan, one of Mao’s primary focuses was on maintaining an independent armed force. And it is this core of several thousand men and women that formed the future People’s Liberation Army (PLA). Mao was deeply nationalist, but at the same time he was totally averse to anything he judged backward, or which made China weaker, even when those things were aspects of Chinese culture itself. This is one of the interesting differences one sees today in Chinese state propaganda, is its emphasis on China’s thousands of years of history and its traditions: Mao waged aggressive cultural wars against traditionalism, as he saw it. To him, it was all part of teaching China and the Chinese to “Stand up,” as he put it, after a century of humiliations at the hands of the western powers and Japan. Mao successfully navigates both Chiang and the Japanese, and he emerges at the end of World War Two clearly the strongest force in China. Americans present as part of the 1944 Dixie Mission to China attest to that. He’s being helped by the Soviets, and will continue to be assisted by the Soviets all the way through the 1950s, even after Stalin’s death. Mao attempts to radically transform Chinese Society by way of a series of Five Year Plans, and he initiates the so-called “great leap forward,” a series of forced agricultural and economic measures that result in millions of Chinese starving to death. In response to criticism by more conservative party members like Deng Xiaoping, Mao launched the cultural revolution in order to effectively decapitate opposition to his continued rule. His deteriorating situation domestically, as well as his increasingly fraught relations with Moscow and the Vietnamese, result in Mao approving of an attempt to reach out to Washington. He died in 1976: just four years after Nixon’s visit and three years prior to the normalization of relations between Washington and Beijing, which we’ll talk about here shortly.The Libertarian Institute, 6d ago
At 20 pages, the document is the barest of outlines of what enterprise technology managers need to do to ensure safe development of generative AI models and methods. Still, a reminder of the basics are always a good thing to keep front and center, and the document could easily be used to construct a custom security playbook and to educate those new to AI developer tools and techniques.SiliconANGLE, 6d ago

Top

In yet other brain areas, certain studies have observed increased neural connections or boosted activity with sensory declines. Slade pointed to research that’s compared older adults with hearing loss to their counterparts without sensory impairment. When researchers gave each group an auditory task, EEG scans showed more electrical signals firing in parts of the brain responsible for complex cognition in the group with hearing loss than the control group.Gizmodo, 11d ago
Our research focuses on the Drosophila larva, an organism endowed with a relatively simple central nervous system, composing approximately 12,000 neurons (Dumstrei et al 2003, Winding et al 2023). Classical conditioning in larvae can be analyzed by stable behavioral assays (Almeida-Carvalho et al 2017, Apostolopoulou et al 2013, Scherer et al 2003, Weber et al 2023a), in conjunction with a wealth of genetic methods for targeting single molecules and neurons (Dietzl et al 2007, Li et al 2014, Perkins et al 2015, Port et al 2020). In addition, the connectome of the brain was recently reconstructed, which enables the extraction and analysis of related wiring motifs, as well as entire learning and memory circuits (Winding et al 2023). Based on these advances, it was possible to establish a more fundamental cellular and synaptic understanding of the larval memory circuit, the mushroom body (MB) network. The MB is a higher-order parallel fiber system present in numerous invertebrate brains, including hemimetabolous as well as holometabolous insects and their larval stages (Strausfeld et al 1998, Strausfeld et al 2020). Analogous to the vertebrate cerebrum, the MB in insects is responsible for forming and maintaining associations (Heisenberg 2003, Menzel 2001, Menzel 2022, Thum & Gerber 2019, Tomer et al 2010, Waddell 2013). In the first developmental stage (L1), the larval MB comprises approximately 110 intrinsic Kenyon cells (KC) per hemisphere, which sparsely encode for conditioned stimulus (CS) information, and is dominated by olfactory input (Eichler et al 2017, Masuda-Nakagawa et al 2009).elifesciences.org, 20d ago
Sleep is a highly conserved and essential phenomenon of the brain and serves numerous cognitive as well as metabolic and immunologic functions. Moreover, the sleep-wake transition represents a specific and prominent change in the brain state (Besedovsky et al., 2019; Rasch and Born, 2013). As compared to a wakeful brain, the sleeping brain shows more synchronous neuronal activities, which can be characterized by electroencephalography (EEG). Sleep has two main stages: the non-rapid eye movement (NREM) state, which is thought to promote clearance of metabolic waste partly through increased flow of interstitial fluid (Feng et al., 2019), and the rapid eye movement (REM) state, with EEG patterns similar to wakefulness yet with muscle atonia as well as vivid dreaming in humans (Besedovsky et al., 2019). In addition, sleep, especially NREM, is directly involved in memory consolidation (Fogel and Smith, 2011; Rasch and Born, 2013). However, the underlying biological dynamics and especially the cellular mechanisms of sleep regulation are not entirely understood (Frank, 2018; Frank and Heller, 2018).elifesciences.org, 19d ago
Overall, developing a reliable neural oscillation detection method is crucial for advancing our understanding of brain function and cognition. The presented CHO method opens up new avenues of research by contributing to the investigation of temporal dynamics, spatial distribution, brain states, underlying mechanisms, functional purpose, and pathologies of neural oscillations. Ultimately, a comprehensive understanding of neural oscillations will deepen our knowledge of the brain’s complexity and pave the way for innovative approaches to treating neurological and psychiatric disorders.elifesciences.org, 17d ago
Their study, published Nov. 21 in eLife, suggests that these memory types all use the same network of the brain, rather than relying on different areas of the brain altogether. This calls into question a previous theory that characterizes general semantic and episodic memory as two distinct systems. Instead, the authors suggest that different long-term memory types could be viewed as a spectrum, where they rely on activating the same areas of the brain at differing magnitudes.medicalxpress.com, 11d ago
Finally, in the year since Megathreats appeared, AI has become an even bigger topic, owing to the public release of generative AI platforms like ChatGPT. I had originally predicted that deep-learning architectures (“transformer networks”) would revolutionise AI, and that does seem to be what has happened. The potential benefits – and pitfalls – of generative AI are profound, and they are becoming increasingly clear. On the positive side, productivity growth could be sharply increased, vastly enlarging the economic pie; but, as was true of the first digital revolution and the creation of the internet and its applications, it will take time for such gains to emerge and achieve scale.interest.co.nz, 9d ago

Latest

As new products — and new promises — hit the market, CISOs should always mind their gaps. In terms of resources, capabilities, and vulnerabilities, what’s currently missing from the SOC? Can AI credibly fill these voids, especially for repetitive tasks? Vendors and their products must be vetted conscientiously to guarantee that they’re adding real value. Be wary of AI tools that make sweeping, general proclamations, and focus on those that solve genuine, specific problems; and be wary of companies that lead with AI, rather than focusing on cybersecurity and the practical application of AI to potential use cases.gbiimpact.com, 6d ago
The adoption of EHRs has improved care but should mostly be seen as foundational to the next stage, one in which we take advantage of our digital data to improve the quality, safety, equity, and efficiency of the system. The new AI creates this potential, and the cost of failing to take advantage of it would be high.The Health Foundation, 6d ago
In much of modern life, cooperation takes a form of people engaging in costly behavior that helps another. It is easy to understand how cooperation might be achieved in small communities where members interact repeatedly. However, in our modern world, there is a high degree of relational mobility -- where individuals can easily change locations and/or social groups. How does this affect cooperative behaviors? I examine this question from both a theoretical and empirical perspective. I first develop a model of repeated prisoner’s dilemma. Individuals are matched but have some ability to leave the relationship. I show that in this environment, perhaps surprisingly, greater relational mobility actually leads to more cooperation in equilibrium, and the model predicts a stronger effect when players are more patient. I take these predictions to the data by first conducting a meta-analysis of twelve prisoner’s dilemma experiments that varied the amount of mobility in and out of relationships. I also examine the predictions of the model using data from the World Values Survey and Gallup World Poll. I find that higher relational mobility in the region is associated with greater cooperation, and this relationship is stronger when individuals are more patient.nationalaffairs.com, 6d ago
Prior research reveals effects of preceding context (also referred to as serial dependence20, 21 and carryover effects22) on timing behavior in tasks with and without a motor synchronization component. Within individual trials of synchronized tapping paradigms, changes in stimulus rate (period perturbation), and stimulus onset times (phase perturbation) result in increased asynchronies between stimulus and tap onsets, more so for phase than period perturbations23, 24, and more so for sequences that speed up than those that slow down16, 24. Across trials, tapping rate in each trial is biased towards the previous trial’s stimulus rate18, 21. Temporal judgments in the absence of motor synchronization are also affected by the properties of stimuli presented in the preceding trial22, 25, 26 and throughout the experiment25, 27. This suggests that temporal judgments are affected by both local and global temporal context. The majority of studies that have revealed individual differences in proneness to history effects20, 28 have not aimed to explicitly estimate the extent and source of these individual differences, or have done so in shorter temporal contexts, using different operational definitions of flexibility than the one used here6. Finally, similar to methods proposed to estimate preferred rate5, 6, 12, 15, 18, 29, previous attempts to measure flexibility6, 16, 18 involved motor responses. Thus, we presented the same stimulus history to participants in two tasks, one with and one without the motor demands of synchronize-continue tapping. This design allowed us to assess the effects of the same predictor (trial-to-trial rate change) on performance in different tasks, and thereby to perform systematic comparisons of oscillator flexibility across perceptual and motor domains.elifesciences.org, 6d ago
Apart from <deceit>, behaviors with tags like <powerseeking>, <criminality>, and <psychopathy> also seem like they should be really useful things to be able to detect and block. Alignment now becomes a matter of building good classifiers for unaligned human behavior on the Internet. [Thus 4chan become a useful part of the pretraining dataset.] Short of an AI sufficiently approximately-Bayesian to be capable of value learning, aligned behavior from an agent is basically rational behavior when motivated only by combination of the emotions <love type="platonic" target="all of humanity">, <benevolence> and complete <selflessness>. Those are three more fairly-abstract classifiers, but it's pretty obvious where to start on them. Consistently staying in that specific combination of motivations is entirely out-of-distribution behavior for humans, as you'd expect from evolutionary theory. However, we're social animals, and almost all humans act pretty aligned with each other a lot of the time. For example, when I'm at work, my employers pay me to act aligned with the well-being of the company and its stock owners, and I do. Ignoring that little motivational detail of a paycheck, my behavior at work looks really aligned to the company. So, labeled at a per-sentence level, aligned behavior is really common from humans, even though basically no humans are actually well-aligned. What is out-of-distribution for a human agent is still acting that way for the benefit of total strangers, and when the human's own life is on the line. But that doesn't seem like it would be very difficult behavior for an LLM to extrapolate to, given a large training set suitably labeled with aspects of aligned behavior showing when humans are acting aligned, and when they stop. Basically, just don't stop, no matter what.alignmentforum.org, 6d ago
Here we investigate whether the emergence of collective oscillations at the population level quenches noise entropy by synchronizing neuronal firing or contributes to an expansion of the number of the possible spike-pattern configurations explored by the circuit by intensifying chaos. To do so, we advance the tractability of large neuronal spiking networks of exactly solvable neuronal models by developing a strategy that allows analyzing the dynamics of delayed spiking networks in a system with fixed and finite degrees of freedom. By building a two-stage model of the action potential generation and transmission, we map the infinite-dimensional system to a finite one and semi-analytically compute the entire spectrum of Lyapunov exponents whose positive sum is a direct proxy for the network’s noise entropy (6). We find that when delays are small, the dimensionality of the attractor increases linearly with the delay while keeping noise entropy constant, analogously to what has been reported in simplified delayed systems (28, 29). Larger delays destabilize the asynchronous irregular dynamics of the spiking network, giving rise to population oscillations in the beta frequency range (∼ 20 Hz). We show that this transition is achieved via Hopf bifurcation of the mean activity at a critical set of parameters that can be computed exactly, and is analogous to what is reported in network models without a dynamical mechanism for action potential generation (15–18). Unexpectedly, the noise entropy, together with the dimensionality of the chaotic attractor, is boosted at the oscillatory instability. To investigate the mechanism that underlies this effect, we drive a network with a periodic external input, to first order, analogous to the one that the network receives at the oscillatory transition. We find that the external periodic drive dramatically boosts noise entropy in the neighborhood of the resonant frequency of the network, and quenches it otherwise. We find that a realistic drive, in which collective activity has short transients of oscillatory activity with drifting frequencies, leads to only moderate changes in the noise entropy. Our results indicate that simple dynamics of the mean activity can have a profound effect on the chaotic dynamics of the network and that realistic transient synchrony signals could, beyond flexibly gating information transmission, prevent boosting of undesired variability in the cortex.elifesciences.org, 6d ago

Top

...5. Machine Learning- Machine learning is a field of AI that deals with the ability of computers to learn from data without being explicitly programmed. Machine learning can be used in AI thesis and research to develop new algorithms for a variety of AI tasks, such as classification, regression, and clustering. For example, machine learning research could be used to develop new algorithms for image classification that can better identify and classify objects in images and videos. Machine learning research could also be used to develop new algorithms for regression that can better predict continuous values, such as the price of a house or the number of customers who will visit a store on a given day. Additionally, machine learning research could be used to develop new algorithms for clustering that can better group similar data points together.Analytics Insight, 28d ago
Similarly, James Watson and Francis Crick discovered the double helix of DNA in 1953. Today, as genetics underlies all modern biology, it is astonishing that a small change in one’s DNA dramatically alters one’s perception of the world. The most profound question is why the genes for synesthesia remain so prevalent in the general population. Remember that about one in 30 people walk around with a mutation for an inwardly pleasant but apparently useless trait. It costs too much in wasted energy to hang on to superfluous biology, so evolution should have jettisoned synesthesia long ago. The fact that it didn’t means that it must be doing something of inapparently high value. Perhaps the pressure to maintain it stays high because the increased connectivity in the brain supports metaphor: seeing the similar in the dissimilar and forging connections between the two. Understanding the laws behind the ability could give us an unprecedented handle on the development of language and abstract thinking, to say nothing of creativity.Popular Science, 10d ago
...“Patients with conditions like OCD, addiction, and depression . . . the networks in their brains responsible for higher-order functions aren’t working properly,” Sun says. “You can imagine that if we can measure these networks and functionally characterize them, we can also manipulate them in a clinical sense. TMS pulses disrupt neural activity in the part of the brain that’s immediately close to the skull or the cortex, which is where these networks are thought to live.”...harvard.edu, 10d ago