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new While some hesitation and a healthy dose of skepticism around AI are probably smart, there is an application for AI far from the headlines, that has the potential to drive seismic shifts in not just how we work, but how we positively impact the community we live in and communities around the world. Already AI is being used to find solutions to complex challenges—whether that be using large volumes of weather data to help farmers in Kenya understand weather patterns and better manage their livestock, or using satellite images to stop deforestation before it begins. AI is also being used to improve health care and patient outcomes through advances in precision medicine, genetics-based solutions, and drug discovery and development.Fortune, 9h ago
new As researcher of the Prehistory Department of the University of Alcalá Francisco Martínez Sevilla explains, “The new dating of the esparto baskets from the Cueva de los Murciélagos of Albuñol opens a window of opportunity to understanding the last hunter-gatherer societies of the early Holocene. The quality and technological complexity of the basketry makes us question the simplistic assumptions we have about human communities prior to the arrival of agriculture in southern Europe. This work and the project that is being developed places the Cueva de los Murciélagos as a unique site in Europe to study the organic materials of prehistoric populations.”...SciTechDaily, 14h ago
new Turmeric, rich in medicinal properties, is considered effective in removing many health-related problems. It is considered to be the most effective way to remove oxidative stress and inflammation from the body. Turmeric is also considered useful in reducing chronic joint pain like arthritis. You will easily find turmeric in every Indian kitchen. It is used in almost every food, apart from this there are many benefits of drinking turmeric milk. Many nutrients like protein, calcium, fiber, iron, copper, and zinc are found in it, but do you know that there are many disadvantages of using excessive turmeric in food? Let us know about its' side effects here:...indiatvnews.com, 1d ago
new There is a need for computational approaches to gain a deeper understanding of protein-peptide interactions and their role in cellular processes and disease mechanisms. While structure-based and sequence-based models have been developed, accuracy remains a challenge due to the complexity of the interactions. PepCNN, a novel deep learning model, has been proposed to solve this challenge by integrating structural and sequence-based information to predict peptide binding residues. With superior performance compared to existing methods, PepCNN is a promising tool for supporting drug discovery efforts and advancing the understanding of protein-peptide interactions.MarkTechPost, 1d ago
new In this seminar, De Michele will present her recent book Anti-Southern Racism and Education in Post-War Italy (Routledge, 2023). This book investigates the racism against Southern Italian children attending North-Western primary schools between the 1950s and the 1970s. Turin serves as the main case study, having become the "third Southern city" after Naples and Palermo during the considered period.Far from being a new phenomenon, racism against Southern Italians gained renewed prominence in the context of the post-war mass internal migrations, becoming one of the pillars of the process of nation-rebuilding. However, in spite of its relevance, it has not received the attention it deserves.By drawing on a wide range of sources – printed, archival, photographic, and oral – and situating itself at the intersection of the history of racism, of education, of psychiatry, and of psychology, the book aims to fill this gap and to add to the debate on the borders that nation-states establish to control the access to power of the different groups inhabiting their territories. Its interdisciplinarity makes it suitable for students and researchers across a variety of subject areas.Grazia De Michele is a Knapp Post-Doctoral Fellow at the Vidal Sassoon International Center for the Study of Antisemitism (Hebrew University of Jerusalem). She obtained her first PhD from the University of Reading (UK) in 2013. Recently, she successfully completed her second PhD at the University of Genoa (Italy). De Michele is a member of the Centre for the History of Racism and Anti-Racism in Modern Italy (CENTRA).School of Advanced Study, 1d ago
new TG/CR: The book is intentionally broad, because exploration by its nature is anything that pushes the boundaries of knowledge. Topics include archaeology, conservation biology, history, geography, oceanography, education, architecture, ecology, ethics, space travel and planetary science, genetics, paleoanthropology and paleontology. Also, we discovered several strong themes running through everybody’s essays that are helping define the future of exploration. The use of technology, the importance of diversity and different perspectives of the way we look at the world, and a sense of urgency to all of this. Exploration today is striving to find the solutions to the problems that face us living on planet earth in the 21st Century.Psychology Today, 1d ago

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new ...deTour 2023 is presented by PMQ and sponsored by Create Hong Kong of the Government of the Hong Kong Special Administrative Region. This 10-day grand design festival will present various programmes for the art and design communities both in and outside Hong Kong. These programmes include creative installations and exhibitions, workshops, design dialogues, movie screenings, guided tours, and many more. 10 years of deTour at PMQ Started in 2014, PMQ's deTour celebrates the 10th anniversary this year. A unique theme has been assigned to each edition of deTour to explore how design could solve social problems and improve our lives. To commemorate this journey, a 10-year retrospect exhibition will be featured in this year's deign festival to look back on the highlighted exhibits and behind-the-scenes of the past decade of PMQ's deTour. This part of the exhibition will be held during the same period as deTour 2023 Design Festival at PMQ and admission is free, as everyone is invited to witness the road to success of deTour, as the contribution of PMQ and deTour in pushing forward the development of the local design industry. The theme of deTour 2023 – "New Know How" – the Interweaving of "Craft", "Design" and "Technology" Working around "New Know How" as the theme, deTour 2023 aims to pave the road to craft design future which takes off with appreciation of traditional craftsmanship. When working, craftsmen are laser focused, highly precise and people oriented, and these qualities are collectively deemed as the "spirit of craftsmanship", which are also regarded as "Know How". Curators of deTour 2023 stated that "this valuable artisanship ought to be applied to different industries. It, together with design thinking and advanced technology, will help take each industry to a new level. By achieving this, problems can be solved more effectively, and through analysing obstacles from a new angle and perhaps trying solutions with new materials and techniques, new creations that are more thoughtful might be possible – this is what we meant by 'New Know How'." Through this design festival, curators hope to bring the industries to re-appreciate traditional crafts from a new angle and make good use of "New Know How" in different sectors. Three Exhibition Areas with 20 International and Local Works The exhibition of deTour 2023 Design Festival is divided into three parts: International Collaboration, Feature Exhibitions and Selected Entries, which are curated under the five specific directions of New Value, Storytelling, Craft Enhancement, Innovation and Heritage. Scattered all over the PMQ premises, 20 design works from the Nethelands, Japan and local designers are open to the public for free appreciation. . In addition, over the 10 days of the design festival, there will be a fruitful programme of a total of 40 workshops, 12 design dialogues and sessions of documentary screening of "Food and Design". International Collaboration: Craft by Nature by Biobased Creations (The Netherlands) deTour 2023's International Collaboration has invited Biobased Creations from the Netherlands, which is a creative studio formed by a group of designers, researchers and artists who aim to encourage the use of biomaterials - also known as renewable eco resources - in daily lives, so as to evolve our world into a regenerative and circular one. Biobased Creations presents Craft by Nature which is an exhibit specially designed for deTour 2023. Shaped like a house, the exhibit allows visitors to find multiple designs made from biobased materials such as furniture, clothes, shoes and socks, and household items. All of these designs are eco-friendly, light in weight and with a minimalistic design, created by designers from Hong Kong and the Netherlands. Outside the house in the garden, visitors can see the "originals" of the materials used in the designs, including common reed, silvergrass and shells, something that we are familiar with. Other than that, Biobased Creations will also display 40 biomaterials that can be applied in architecture and heat insulation, and visitors are welcome to hold and feel these materials and scan the QR code to instantly learn how these biomaterials are made. Craft by Nature is an innovative installation demonstrating how materials that are ignored or abandoned can be transformed into chic designs, and this allows us to rethink our relationship with the nature and invites us to take one more step forward to make our world better. Feature Exhibitions: Exploring traditional crafts with a fresh eye...SME Business Daily Media, 1d ago
new It's not just the U.S. that is exploring the potential for REE deposits in coal mines as researchers in South Africa are also assessing the possibility of mineral extraction. The Clean Coal Technology research group at the University of Witwatersrand, Johannesburg published a paper earlier this year that discussed the chemical composition of coal. The group found that the REE content in the coal being analysed was over 225 parts per million, a concentration higher than the cut-off grade of 130ppm needed to extract rare earths in coal. This means that the coal can be reprocessed as raw materials to be used to support renewable energy production and clean technologies. This is just one of several areas of exploration by governments and researchers to find innovative ways to access critical metals and minerals for clean energy production.OilPrice.com, 2d ago
new At the core of this innovation is the ability to capture and process vast amounts of data – a hallmark of AI’s capabilities. The researchers at the University of Copenhagen conducted wine tastings with 256 participants, translating the sensory experience into data points that an AI could understand and learn from. The result is an algorithm that predicts wine preferences with unprecedented accuracy, a significant step towards personalised gastronomy.IO, 2d ago

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Prof. Riby began his academic life studying for a PhD at Bristol University in experimental psychology on the topic of attentional control and multi-tasking in ageing. He then moved on to Stirling University to obtain his post-doctoral training in the use of multimodal brain imaging in the investigation of human memory. This early work was influential in driving his interest in the use of mixed methodology (behavioural, neuropsychological and imaging) to explore some of the critical research challenges in the field of gerontology. For instance, a programme of work is using brain imaging techniques (EEG and fMRI) to examine self-generated thought and mind-wandering patterns across the lifespan. The research examines how differences in brain network connectivity in ageing between temporal and prefrontal brain regions predicts positive impacts on behaviour (e.g. creativity; problem-solving; positive aspects of self-reflection). Beyond fundamental science, his intervention work aims to use what we have learnt in the lab to build novel and engaging programmes to encourage the use of untapped brain resources, promoting enhanced mental performance and wellbeing as we grow older. Prof. Riby’s work overall aims to lead theoretical and methodological development of successful and less successful ageing (e.g. diabetes; dementia) with the emphasis that decline is not inevitable. Further interests include the nutritional neurosciences, cognitive neuroscience of mindfulness/meditation and the link between mindful running and psychological wellbeing. More recently, Prof. Riby is conducting a series of behavioural and neuroscience investigations on music's potential to heal the mind.EconoTimes, 19d ago
The prize is clear. The construction industry is facing numerous challenges in the face of Net Zero targets, and one potential route to successful evolution is through the widespread adoption of advanced materials. The cement industry has one of the highest carbon footprints of any industrial sector, producing between 8-10% of global CO2 emissions. We are working on ways to mitigate the impact of the industry by using Graphene to substantially reduce the amount of cement, concrete and steel required in building projects – and find market-viable solutions to sustainability across the whole lifecycle of buildings and the built environment, from construction phase to operation and end-of-life.Decarbonising construction with Graphene, 23d ago
The development of artificial intelligence (AI) presents significant opportunities for economic and social flourishing. The release of foundational models such as the large language model (LLM) ChatGPT4 in early 2023 captured the world’s attention, heralding a transformation in our approach to work, communication, scientific research, and diplomacy. According to Goldman Sachs, LLMs could raise global GDP by 7 percent and lift productivity growth by 1.5 percent over 10 years. McKinsey found that generative AI such as ChatGPT4 could add $2.6-$4.4 trillion each year over 60 use cases, spanning customer operations, marketing, and sales, software engineering, and R&D.1 AI is also impacting international trade in various ways, and LLMs bolster this trend. The upsides of AI are significant and achieving them will require developing responsible and trustworthy AI. At the same time, it is critical to address the potential risk of harm not only from conventional AI but also from foundational AI models, which in many cases can either magnify existing AI risks or introduce new ones.Brookings, 17d ago
Antimicrobial resistance (AMR) is one of the highest concerns in modern health care. While potential new drugs are reported regularly, only a few reach the clinical trial state after years of preclinical testing. Therefore, increasing the preclinical screening efficiency and designing more efficient drugs are of utmost importance to combat AMR. One way to deal with this is to understand the fundamental mode of action of these potential drugs at the molecular level. In the present proposal, I will build a methodology that will provide such information and help pharmaceutical research in screening and designing more efficient drugs.University of Groningen, 3d ago
Newswise — ROLLA, Mo. – A Missouri University of Science and Technology research team was recently awarded $2.5 million in funding to find new ways to turn waste products into supplementary cementitious materials (SCMs) – plus use those materials to store carbon permanently in concrete.“Years ago, SCMs were used as a cheap option to replace some Portland cement and also have a stronger and more durable concrete mixture,” says Dr. Hongyan Ma, Francisco Benavides Scholar and associate professor of civil engineering at S&T. “There is now a severe shortage of these materials, so my team is looking at creative ways to develop new alternatives that are carbon-negative and will make the industry greener.”Ma also serves as director of S&T’s Laboratory of Future Cements and Carbon-Negative Initiatives.He says one of the most common SCMs has traditionally been coal combustion residue, or fly ash, but a large percentage of this type of waste is not currently usable in cement. According to the Electric Power Research Institute, 2.5 billion tons of this type of waste have been disposed of in ponds and landfills throughout the United States.Ma’s two-year research project, which received a $2 million grant from the U.S. Department of Energy and $500,000 in matching funds from S&T and industry partners, aims to make this unusable waste into something of value.The research will also cover the ash from municipal solid waste incinerators, steel slag, recycled concrete and other waste products. The team is currently developing processes to break down the structure of the solid wastes in ways that will also allow them to store CO2.The carbon that is combined with these new SCMs will primarily come from the flue gases of power plants and the manufacturing industry, Ma says. By using CO2 directly from the flue gasses, as long as the concentration is high enough, his team will not have to use energy-intensive carbon-capture methods.Ma says this project is designed to make a significant difference in the concrete industry in the near future, as opposed to focusing on more general, long-term concepts.“The work we are conducting is mission-oriented,” he says. “Part of our research is to make sure what we develop is economically feasible. It can’t be too expensive, as it needs to be a realistic option to support the supply chain.”Ma is the project’s principal investigator (PI). Serving as his co-PIs at Missouri S&T are: Dr. Aditya Kumar, associate professor of materials science and engineering; Dr. Mahelet Fikru, associate professor of economics; and Dr. Wenyu Liao, assistant research professor of civil engineering. Lawrence Livermore National Laboratory is also collaborating with S&T for the project.For more information about Missouri S&T’s civil engineering programs, visit care.mst.edu.About Missouri University of Science and Technology Missouri University of Science and Technology (Missouri S&T) is a STEM-focused research university of over 7,000 students located in Rolla, Missouri. Part of the four-campus University of Missouri System, Missouri S&T offers over 100 degrees in 40 areas of study and is among the nation’s top public universities for salary impact, according to the Wall Street Journal. For more information about Missouri S&T, visit www.mst.edu.newswise.com, 23d ago
..."After undergraduate studies in maths and physics, I turned to biophysics because I was curious to unravel fundamental mysteries of life and dreamed that my research yields practical applications on improving human health and solving real-world problems. During the last year of my PhD, I had a chance to work with Jean Lepault, a fantastic scientist who contributed to developments of cryo-electron microscopy (cryo-EM) alongside Nobel laureate Jacques Dubochet. I became fascinated by the beauty of macromolecular complexes, and I have been working with cryo-EM ever since. Our research team focuses on structure, assembly and dynamics of multicomponent systems involved in microbial infection, stress response and signalling. The hallmark of our research is the combination of cryo-EM, and since recently also cryo-electron tomography (cryo-ET), with an array of complementary biochemical, biophysical and optical imaging tools. As our main passion revolves around imaging and deciphering the structures of enigmatic and challenging objects, we eagerly engage in collaborations leveraging our expertise to make meaningful contributions towards solving important biological problems."...umu.se, 6d ago

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new Liquid-crystal (LC) phase modulators are widely used in optical systems because of their advantages of low power consumption, light weight, flexible bandwidth adjustment, and non-mechanical movements. However, most LC phase modulators are polarization-sensitive, meaning that they affect the phase of light differently depending on its polarization. This can limit their performance and functionality in some applications.There are two main approaches to realizing polarization-independent LC phase modulators. The first approach is to use polarization-independent LC materials, such as polymer-stabilized blue-phase liquid crystals (PS-BPLCs). However, PS-BPLCs require high driving voltages, which can make them impractical for some applications.The second approach is to change the alignment of the LC directors. One way to do this is to use a double-layer LC cell, which consists of two LC cells stacked on top of each other with their LC directors oriented orthogonally. This allows light to be decomposed into two orthogonal components, each of which experiences the same phase modulation. However, double-layer LC cells are complex and difficult to manufacture.Another way to achieve polarization-independent LC phase modulation is to use orthogonal photoalignment. This involves using a special photoalignment layer that creates orthogonal alignment domains in the LC. However, it is difficult to achieve precise alignment using this method.In a new paper published in Light: Advanced Manufacturing, a team of scientists led by Professor Jiangang Lu have developed a new approach to polarization-independent LC phase modulation.Polarization-independent LC phase modulation is based on a light-controlled azimuth angle (LCAA) process. The LCAA process uses the optical rotatory effect of cholesteric liquid crystals (CLC) to create single-layer, multi-microdomain, orthogonally twisted (MMOT) structures.MMOT structures are composed of multiple microdomains with orthogonally aligned LC directors. The LCAA process uses a patterned light beam to control the alignment of the LC directors in each microdomain. This allows the researchers to create MMOT structures with precise alignment.LC phase modulators with a single-layer MMOT structure have the potential to be both polarization-independent and have a large phase depth. This makes them ideal for a wide range of applications, including optical communications, wearable devices, and displays.A light-controlled azimuth angle (LCAA) process can be used to fabricate a multi-microdomain orthogonally twisted (MMOT) device with low polarization dependence, high phase retardation, and a simple structure. The alignment angle between the top and bottom substrates in the LCAA process and the mask grid size of the MMOT structure can be tailored to meet the requirements of different applications.This device has the potential to revolutionize the way we use light in a variety of applications. For example, it could be used to create new types of optical communications systems that are more efficient and reliable. It could also be used to develop new types of wearable devices that can display information in a more clear and concise way.newswise.com, 2d ago
new INFRASTRUCTURE opportunities centered on increasing access to composting/food scrap hauling services. Increasing the number of free drop off locations located at farmers markets, gardens, churches, public parks, and schools was mentioned numerous times possibly indicating a belief that this might be the easiest or quickest approach to the adoption of composting if “ drop-off sites [were] in every neighborhood .” More gardens could also host on-site community composting if they had money available to pay stewards. Increasing municipal collection ( "Bins for All!") and community composting efforts and expanding options for home composting and for renters were all mentioned as options to increase access as was the development of a compost (service) directory. Regardless of how access to composting services was increased it should be affordable as “[you] shouldn't have to pay to do right thing.” Opportunities to utilize more appropriate technology abound including using AI for sorting to reduce contamination, developing rat-proof bins (for collection and home composting), using biodigesters, and perhaps creating a new type of facility to handle (plastic-based) ‘compostable’ (biodegradable) serve-ware. To support the development of infrastructure opportunities incentives such as "raising landfill tipping fees [or creating a] methane tax on private LF owners" and funding such as the "potential to pursue Federal funding to pilot creative programs" are critical. Increasing collaboration and coordination is also an opportunity to develop infrastructure with at least one participant wondering, “ Where is regional planning org? (e.g. CMAP)” and now is the time to increase collaboration because "passion exists among food producers in the region who need soil!!" Rather than looking to individual households for new sources of materials to make compost, restaurants, breweries, and landscapers and other large food waste generators could be better engaged and plugged in to composting perhaps driving or at least raising awareness of the issue for individual households. Attendees also mentioned as opportunities new places to process and acquire compost or new ways to handle food waste that included empty warehouses and factories, vacant lots, big box stores offering pickup of compost and drop off of scraps and sending food waste from large institutions to hog farms 4 . A list of comments on Opportunities in Infrastructure are displayed in Table 8, Appendix 1. POLICY opportunities included creating mandates for large generators (such as grocery stores, food processors, schools and universities) to compost and for public projects (roads, landscaping, buildings) to use finished compost. These two policy changes have the power to directly increase demand and may work to create a consistent end market for finished compost. There may exist a scalar mismatch in the region for compost— demand by individual consumers may be too small to justify the amount of effort it takes to create the compost so there needs to be "more emphasis on getting more finished compost to market." Other opportunities to increase demand for the finished product and access to services include passing Right to Compost legislation “so that building managers and landlords don't stand in the way" of their residents using compost pick up services; instituting bans and creating incentives and/or disincentives such as increasing landfill tipping fees ; and incentivizing compost usage by farmers and public works. Creating consistent, stable, and expanded end markets for finished compost and the support for processing infrastructure is extremely important when implementing policies that would increase the amount of feedstock available to create compost. Policy opportunities that did not require a large lift included creating new or expanding existing programs as "many municipalities already accept leaves & lawn clippings. Expanding to collecting food waste scraps is low- hanging fruit" and ensuring that funding is sufficient especially for creating technical assistance positions to support compost collection and processing. Also identified as an opportunity is to increase regional coordination...extension.org, 2d ago
new CCA's mission is to forge new connections between science and art, people and technology. The founding director is the conductor and TUM honorary professor Felix Mayer: "The TUM Center for Culture and Arts wants to question the latest technological developments for their significance for the arts, it wants to offer students new academic teaching formats, it wants to arouse curiosity and feed and fuel the intellectual zest for life." TUM President Prof. Thomas F. Hofmann emphasizes: "With the TUM Center for Culture and Arts, we want to offer a wide-ranging, inspiring program, from music and literature to visual, performing, and digital arts. We want to support students, employees, alumni, partners, and friends in discovering previously hidden talents and to develop new inspiration and creativity through this combination of science and culture. We want to encourage creative ways of thinking and working and give people deeper access to less familiar fields of science through art and culture.“ The CCA is located under the umbrella of the TUM Institute for LifeLong Learning, which is headed by TUM Executive Vice President Prof. Claudia Peus: "At TUM, it is our declared goal to attract talents in all their diversity and to give them the best opportunities to develop their potential. At the same time, we want to be servants of society and shape the progress of innovation responsibly. Art and culture offer unique opportunities to appeal to and inspire the most diverse groups of people and give them impetus for further development, including people who might not normally come to university."...tum.de, 2d ago
new Ammanath: As a technologist, I have somewhat of a different lens on the issue of trust and integrity. Fundamentally, I believe that technologies such as artificial intelligence (AI) are powerful tools with untapped potential to improve business and society as a whole. But there are also risks in deploying technology to make decisions and to expect people to view technology as something that should, and can be, ethical. That is why a growing number of organisations and leaders are doubling down on developing ethical technology guidelines and eminence. An organisation’s purpose office has a role to play, and this is why it is important to invest in technologies that are safe, transparent and unbiased. These powerful technologies should not only help solve problems, but be governed and applied to do so with the appropriate intent.Financier Worldwide, 2d ago
new Will it be possible to end HIV by 2030, as the UNAIDS association aims for? Forty years of research on HIV have made it possible to advance, particularly on triple therapy treatments, which prevent the last phase of the infection called AIDS, then more recently on Prep, a preventive treatment which prevents infection in the event of exposure. But there is still a long way to go to truly overcome the disease. “We continue to be interested in the replication of the virus and in understanding how certain carriers escape the pathology of the virus. HIV. It is hoped that this work will resolve certain aspects of the infection, particularly in the face of failure of vaccine in recent years», declares Christophe d’Enfert, scientific director of the Pasteur Institute, which is hosting 3 days of conferences on HIV from November 29 to December 1. Where is the basic, clinical and social research work? Le Figaro make the point.Archyde, 2d ago
new In exploring the realms of materials science and biochemistry, researchers are particularly interested in protein and peptide nanostructures found in nature, known for their potential as bioelectronic materials. The creation of synthetic analogs, capable of forming one-dimensional nanostructures, is a significant stride in understanding natural systems and developing new materials.nanowerk.com, 2d ago

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The experts have suggested four key elements -- integration, ecosystem integrity, transformation and urgency -- that should guide debates at COP28 and beyond over how best to design and deploy innovative solutions to biodiversity loss and climate change.Under Integration, The IUCN Commissions chair mentioned that the climate challenges require coherent, consistent, and integrated efforts on the part of governments at all levels, sectors, and systems; multilateral and bilateral institutions; communities; businesses; scientists and others to limit global warming to maximum 1.5 degrees Celsius.While talking about ecosystem integrity, the experts put forth that sustaining healthy ecosystems is essential to halting biodiversity decline and species extinctions and to maintaining ecosystem services that underpin human well-being."Addressing the biodiversity and climate crises will require systemic changes in the way we live, changes that can only be achieved through rapid and far-reaching actions across all sectors of a type, scale, and speed never before attempted," the experts said while emphasising on the need for transformation to address climate change.While highlighting the urgency of the situation, the letter mentioned: "The window of opportunity to address climate change and biodiversity loss is still open, but it is closing rapidly".Business Insider, 5d ago
In the vast and diverse landscape of African growth investing, more opportunities abound today than ever before. Africa’s recent growth surge has created a large group of companies already scaling successfully, while the current market environment has reduced the capital available. This untapped potential between high quality investment “demand” and reduced capital “supply” extends to various commercial sectors, including logistics, HR, and insurance, all presenting significant high value “white spaces” waiting to be filled. For those looking to invest in Africa, especially in high-growth, digitally-driven companies, these markets offer immense potential.African Investment in Developed Digital SectorsAfrica’s digital sectors are leading the way in terms of economic viability on the continent. These sectors encompass fintech, tech-enabled commerce (such as logistics, supply chain, mobility, digital health, and education), and renewable energy. These industries revolve around key themes like financial inclusion, climate change mitigation, and poverty alleviation.With low manufacturing capabilities, high youth unemployment rates, poor-quality health care, and inadequate infrastructure, Africa’s sustained growth now depends on its digital economy. Crucially, the continent has historically exhibited a remarkable ability to “leapfrog,” for example by embracing a mobile-first approach and swiftly adopting digitally managed renewable energy. This digital-first mindset, often born out of necessity, has made these sectors essential employers, providing opportunities for the millions of Africans entering the job market annually.A Growing Investment LandscapeIn recent years, investment in African start-ups has surged, exceeding $5 billion in 2021. However, this figure has dipped sharply due to global macroeconomic issues and specific African challenges. Despite this growth, two significant “white spaces” continue to exist in the African investment landscape.The first gap is in the range of $10-25 million scale-up funding rounds. The second is the lack of customised, structured non-equity financing to support company growth. Notably, because the vast majority of African investments are impact or mission-driven, focusing on positive social and economic change, this provides a natural path to overlay specific investors’ objectives, such as gender-lens investing, climate positivity, or financial inclusion.The $10-25 Million Funding GapIn the chart below, based on proprietary research, we can see the number of investors active in Africa categorised by the size of their investments. On the left are the traditional African start-up investors, usually committing less than $5 million. To the right are investors, including international or regional players, whose criteria demand larger investments, usually exceeding $20 million. This gap between $5-20 million is where relatively few investors are actively engaged, creating a significant opportunity for future investments. There is a yawning gap: Several forward-thinking funds have recognised this gap and are adapting to address it. Investors like Norrsken, Partech, and TLCom have or will naturally raise larger funds to support these companies’ growth. Simultaneously, the number of quality African companies qualifying for such funding is on the rise, leading to increased demand that will outstrip the capital supply for many years. This persistence in the funding gap presents a compelling investment opportunity.Structured Financings in AfricaNon-equity capital is still in its early stages of development in Africa. Typically, local currency debt is primarily offered by banks, but these institutions are known for being burdensome, expensive, and reluctant to support companies looking to invest in growth, which naturally reduces profitability in the short term. Moreover, their financial products tend to be relatively basic and are usually accessible only to larger, well-established businesses at the top of the economic hierarchy.Dollar-denominated debt, on the other hand, is available in various forms, with a significant portion originating from Development Finance Institutions (DFIs) or similar organisations. However, the innovative financial structures and speed of execution required in Africa are often lacking from these sources.This issue is compounded by the fact that many African companies, particularly those aiming for growth, rely at least in part on selling money in some form to generate profits in their operations. This can take the form of financing productive assets like motorcycles, mobile phones, solar pumps, or even embedded finance such as providing financing to retailers for weekly stock replenishment, funding agricultural inputs with guaranteed off-take, or supporting the deployment of POS terminals for agent banking. We estimate that over 70% of African scale-up businesses generate income through these “money resale” activities.This dependence on money resale for income makes it financially impractical to rely solely on equity financing. Equity returns are typically around 30% annually, while financing margins, especially for commercial financing, are usually much lower. Consequently, companies cannot afford to “burn” capital in this way to simply fuel growth.Examples of this kind of capital are diverse. They include payments companies seeking up to $10 million to support the purchase and distribution of POS terminals to contracted merchants, providers of renewable power products looking to transfer an initial $20 million+ of dollar-indexed receivables generated from three markets to an off-balance sheet Special Purpose Vehicle (SPV), with the potential to expand to $40-50 million to enhance liquidity, and even large companies looking to finance a second year of market entry through a mix of debt and equity, since banks typically require 2-3 years of evidence before lending the first $, even if a client has $100m+ of revenue already.This structured finance gap is often filled by DFIs, which, while invaluable to the African ecosystem, may not be an ideal fit for most growing companies. They tend to be cumbersome, inflexible, demand extensive reporting, and have less tolerance for the dynamic evolution of growing businesses. Although some flexibility has been introduced in recent years, the need for structured finance remains unmet across the continent, necessitating earlier risk-taking and a faster response time than current providers can offer.Victor Basta is CEO of DAI Magister, a global investment banking firm.Financial Nigeria International Limited, 28d ago
It is exciting to learn that physicist Prof Gopal Dixit of the Indian Institute of Technology Bombay has been actively contributing to the field of attosecond physics. “I was sure that sooner or later the field of Attosecond Physics would be awarded a Nobel Prize. It is such a fundamental topic in nature as well as has a huge potential to make a big leap in upcoming quantum technologies,” he says. Prof Dixit and his team are working on several theoretical aspects and applications of attosecond physics. They have been helping solve some of the problems that the Nobel laureates, their teams and other researchers aim to solve.iitb.ac.in, 25d ago

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new Dr. Alexander Redenius, head of Resource Efficiency and Technology Development at Salzgitter Mannesmann Forschung adds, "We have been working successfully with the Fraunhofer researchers for six years to transform steel production. The direct reduction demonstration plant enables us to optimize the reduction process and how it interacts with the other process steps. Through this work, we are creating the basis for sustain-able steel production with low CO2 emissions." The company aims to convert a third of its steel production to the climate-friendly process with hydrogen as early as 2026.techxplore.com, 2d ago
new As a physician-scientist, Perlmutter is internationally recognized for his research on alpha-1 antitrypsin deficiency (ATD), a genetic disorder in which accumulations of a misfolded protein can cause severe liver damage. His work has led to advances in the understanding of how cells dispose of misfolded proteins that cause cellular dysfunction as well as the development of a pipeline of ATD drugs that could eliminate the need for liver transplantation in those with the disorder. Since drugs in this pipeline target and enhance autophagy, a cellular degradation pathway that is critical for the functioning of all cells and declines with age, they also represent exciting candidates for prevention of cognitive decline and other degenerative diseases of aging. Perlmutter and his collaborators recently discovered that a drug currently used for Type 2 diabetes may slow age-dependent degeneration in the nervous system and in the liver.Washington University School of Medicine in St. Louis, 2d ago
new While the Sino-Indian competition in Bangladesh is more well-known, and is often mentioned in Chinese, Indian, Bangladeshi and other foreign publications, the rise of Sino–Japanese competition through aid and investment is not sufficiently examined in policy debates. Both countries provide Bangladesh with different types of aid and investment opportunities, which presents policymakers with potential opportunities as well as challenges. Ideally, Bangladesh will be able to continue to benefit from both sources of investment. However, recent developments, such as the early-2023 decision to pass over China and instead award Japan with the contract to build the Matabari deep-sea port, suggests that rising geopolitical competition may not permit such a simple future. Thus, the public ought to be fully informed of the discrete Sino-Japanese competition in Bangladesh in order to drive informed debate over how to navigate competing investments in a careful and pragmatic manner.South Asian Voices, 2d ago
new The prime challenge is high cost, a shortage of competent individuals and a lack of norms and protocol because of lockdowns and isolation in emerging countries, which is predicted to slow the growth of the antibody-coupled T-receptor therapy market. The creation and delivery of ACTR therapy can be costly, making it unaffordable for a larger patient population. Due to the complex production procedures, intensive clinical testing, and specialist equipment required, the high prices may discourage its adoption, especially in places with low healthcare resources. Furthermore, ACTR therapy faces competition from well-established immunotherapies like CAR-T cell therapy, widely used in clinical practice. Potentially stifling the growth of the ACTR therapy market are the numerous available and effective alternatives that consumers and healthcare providers are weighing when making treatment decisions. All of this results from the tremendous efforts made in response to the worldwide public health emergency caused by COVID-19 and the decades of progress that have made it possible to create antibody therapeutics. Another antibody, tocilizumab, which is anti-IL-6R, has recently been approved for treatment in COVID-19 and has previously been approved for use in other contexts. Regional Trends:...openPR.com, 2d ago
new Most importantly, the RISE grant helped Northeastern purchase its simulators, which include a birth simulator, a pediatric simulator and two adult simulators. Using the simulators students can do everything from listen to heartbeats and breathing sounds to insert a catheter and their patients are even able to talk to them and answer questions.Instructors shared that the simulators are invaluable because they help students grow their confidence and figure out what they still need to learn while realizing just how much they already know. Plus, it's a great place for students to apply what they've learned in the classroom.Nursing students commented that the simulators help make them more comfortable, teach them time management, provide valuable hands-on experience outside of the classroom and allow them to work on their critical thinking skills."I like simulation because it is a place for me to make errors and not have to worry about killing the patients," Brandon Williams said.Before watching a demonstration of the birth simulator, the group heard from Jennifer Garcia, a student who benefited from the RISE grant and in May will be graduating with an RN (Registered Nursing) degree. From California, she was working a dead-end job when her sister was accepted into NJC's program and encouraged her to enroll. After taking a job at Sterling Regional MedCenter as an inventory associate to make sure that healthcare was right for her, she fell in love almost immediately and went to work earning her CNA degree."Being from out of state it's been very difficult for me," Garcia said, explaining that the cost for her to attend Northeastern is much higher than a student who has lived here all of their life. "I wasn't sure I would be able to afford it and then came the RISE grant. It just lifted this great burden off me and I was able to focus all of my time and attention into preparing my skills.""I am very grateful to the RISE grant for everything it has given me because I feel that I have a purpose," Garcia added, sharing that she plans to work in the community when she graduates.Next, Giacomini shared how for years, she and Brower discussed how they could partner with students coming in, who often come from a country where they were a veterinarian or a doctor but now they need to get the skills and credentials to be able to work in the United States. Through the RISE grant, they were able to remove the financial barrier for some of the students and it also helped them create an integrated education and training program.Northeastern found a cohort of students whose language proficiency was just enough that they could have a basic conversation but they needed language skills specific to a CNA, which they got through a customized English training that was developed. The college also worked with them on workforce preparation skills like communication, time management, learning cultural differences, etc."It was great to finally pilot this program that we'd been trying for so long to get together," Giacomini said, adding that now those students are recruiting others to the CNA program.Next, was the simulation, which involved a pregnant woman who came in stable but started deteriorating with her heart rate and blood pressure showing signs of distress and her oxygen level dropping. She then experienced an eclamptic seizure due to high blood pressure and when the mother awakened it was determined she was in labor. The mother went on to deliver a healthy baby girl, who was examined for any problems and vaccinated.After the simulation, the group heard from Shelly Griffith, CEO of Eben Ezer Lutheran Care Center, one of Northeastern's main clinical sites for both nursing and CNA students."We rely heavily on (NJC) to help train CNAs, individuals who are looking to pursue an entry point into the medical field," she said. "The beauty of NJC is they have been able to flex some schedules and be able to accommodate those who may need to be working full-time while they are looking to grow their career options."NJC's program is especially critical given the shortage of healthcare workers. Griffith shared Eben Ezer has a need for 20 CNAs right now,"What's happening is the demand for our service is significant and so people are having to go on a wait list, which means that many people, their needs are not being met because nursing homes throughout the rural communities are not able to meet that need because of limited staffing levels," she explained.Following her remarks, guests had a chance to try out the simulators themselves.The day ended with a panel discussion that included Tamara Durbin, executive director of Northeast Colorado BOCES; Kyle Stumpf, Superintendent of Holyoke School District; Danielle Ongart, Executive Director of Colorado Department of Education's Student Pathways; and Misti Ruthven, Director of Education and Training Innovation for the Office of Governor Polis.They talked about the importance of career connected learning as it benefits both students and the economy by opening students' eyes to career opportunities they might want to consider. Stumpf mentioned the success of his district's internship program.The group also talked about some of the barriers that exist to providing this, the biggest being cost, especially in northeast Colorado where it costs a lot to transport students from their school to another school that offers the program they're interested in. There is also the challenge of trying to ensure all students have equitable access. Durbin pointed out that students who live in northeast Colorado need to have the same opportunities available to them as those on the Front Range.During a question and answer session with the audience, Trae Miller, executive director of the Logan County Economic Development Corporation, pointed out that internships and apprenticeships sound great but the state requirements that go into those and the reporting aspects create a barrier for businesses to participate in those programs. He also shared that students need help with basic skills such as showing up on time and learning how to take instruction.Ongart suggested there needs to be a regional entity in place to help students and businesses navigate this, so it doesn't all fall on the district or the business, and Stumpf mentioned his district teaches a class an hour a day with all of those skills and they also provide businesses with funding to help offset the costs of doing an internship.State Sen. Byron Pelton asked why the state is reinventing the wheels with apprenticeships, instead of learning from what's in place now. He said his frustration with recent legislation regarding apprenticeships is "you're going to have a lot of outside forces that are going to try to do their best to send it one way or the other when we need to just worry about the entire workforce, not just a little part of it; we need to worry about the entire workforce." Pelton pointed out in two years, half of Colorado's electrical trade will be retiring, "so we've got to get more people in there," he commented.He also said would like for time in college courses to count toward credit for both college and high school, which he plans to introduce a bill to require."We realize the importance of apprenticeships and we have challenges in trying to determine those opportunities for youth in high schools and have that be seamless for them," Durbin said, adding that it's something they are working on.©2023 Journal-Advocate, Sterling, Colo. Distributed by Tribune Content Agency, LLC.GovTech, 2d ago
Ayman Ismail, Vice President of Business Development & Government Affairs & Strategy, Schneider Electric commented: “Technology is one of the keys to unlocking the potential of the energy transition and securing net zero. There is a myriad of technical, financial, industrial, and operational challenges to accelerating the development of tech-enabled climate solutions. Our goal remains to drive multi-sectoral collaboration and create a platform to influence industry conversations through inclusive discussions to create concrete impact in the region and beyond.”...mid-east.info, 3d ago

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Newswise — In a new study published in The Journal of Finance and Data Science, a researcher from the International School of Business at HAN University of Applied Sciences in the Netherlands introduced the topological tail dependence theory—a new methodology for predicting stock market volatility in times of turbulence."The research bridges the gap between the abstract field of topology and the practical world of finance. What's truly exciting is that this merger has provided us with a powerful tool to better understand and predict stock market behavior during turbulent times,” said Hugo Gobato Souto, sole author of the study.Through empirical tests, Souto demonstrated that the incorporation of persistent homology (PH) information significantly enhances the accuracy of non-linear and neural network models in forecasting stock market volatility during turbulent periods.“These findings signal a significant shift in the world of financial forecasting, offering more reliable tools for investors, financial institutions and economists,” added Souto.Notably, the approach sidesteps the barrier of dimensionality, making it particularly useful for detecting complex correlations and nonlinear patterns that often elude conventional methods.“It was fascinating to observe the consistent improvements in forecasting accuracy, particularly during the 2020 crisis,” said Souto.The findings are not confined to one specific type of model. It spans across various models, from linear to non-linear, and even advanced neural network models. These findings open the door to improved financial forecasting across the board.“The findings confirm the theory's validity and encourage the scientific community to delve deeper into this exciting new intersection of mathematics and finance,” concluded Souto.newswise.com, 12d ago
The lack of knowledge about the molecular mechanisms that make biocatalysis possible is an obstacle to developing biotechnological processes that allow the recycling of plastics. A research project led by a team from the Universitat Jaume I has made it possible to degrade widely used PET plastics through a natural enzyme, CALB, by modifying the pH of the medium. This opens up a new way to recycle PET, which is present, for example, in containers, bottles or textiles of all kinds, and generates harmless compounds that are useful in subsequent synthesis processes.phys.org, 27d ago
Both animal and cell culture models have been developed to facilitate the study of cerebral ischemia. In vivo, middle cerebral artery occlusion (MCAO) in rodents can produce reliable and well-reproducible infarcts and became a commonly used approach to mimic human ischemic stroke. In vitro, many cell-based models, using cells treated with chemical inhibitors, enzymatic induction, or hypoxia and energy depletion, were developed to replicate key features of ischemia [7]. Even though they cannot recapitulate the complex response of stroke in intact animals, they serve as convenient and amenable tools to study ischemia-reperfusion injuries via biochemical, genetic and genomic methods. For example, oxygen-glucose deprivation (OGD) treatment has been widely used to examine the cellular mechanisms involved in cerebral ischemia and to identify potential neuroprotective agents and pathways [8]. In this study, we used the OGD model in the immortalized mouse hippocampal neuronal cell line HT-22 and carried out an RNAi screen on epigenetic regulators. We identified Prmt5 as a novel negative regulator of neuronal cell survival after OGD. We further showed that it promoted cell death by repressing genes involved in Hedgehog signaling, and its inhibition provides protection against ischemic injuries both in vitro and in vivo. Together, our findings revealed a novel epigenetic mechanism that contributes to neuronal cell death in cerebral ischemia and uncovered a potential target for neuroprotection.elifesciences.org, 19d ago
In humans and other mammals, loss of neurons in the retina due to trauma or disease is an irreversible process that can lead to blindness. But unlike humans, some animals, such as fish, have the ability to spontaneously regenerate neurons in the retina by turning another retinal cell type, called Müller glia (MG), into neurogenic progenitors. Research headed by a team at the University of Washington has now shown how, in a lab setting, human Müller glia can also be coaxed into changing their identity, potentially offering up a new source of neurons for treating vision loss. “Overall, our study provides a proof-of-principle that human glia can be reprogrammed to cells that are capable of making new neurons,” said research lead Thomas Reh, PhD. “This opens up an entirely new way to repair the retina in people that have lost neurons to disease or trauma.”...GEN - Genetic Engineering and Biotechnology News, 4d ago
Newswise — Microorganisms, such as bacteria and sperm, can undergo adaptive shape morphing to optimize their locomotion mechanisms in the environment, which enables them to navigate complex barriers and improve survival. Inspired by this autonomous behavior, artificial reconfigurable microrobots have been proposed to realize similar adaptation capabilities.Helical microswimmers are particularly promising for biomedical applications because of their unique propulsion mechanism. Under a rotating magnetic field, helical microswimmers can transition dynamically between tumbling and corkscrewing motions, allowing them to navigate complex terrain and achieve targeted drug delivery.In a new paper published in Light: Applied Manufacturing, a team led by Professor Jiawen Li from the University of Science and Technology of China has developed new ways to make helical microswimmers that are very small, with dimensions in the micrometer range. This is important because many biological structures, such as cells, capillaries, and wrinkles on cell surfaces, are also very small.Microscale helical microswimmers are promising tools for biomedical applications, such as drug delivery and targeted therapy. However, some challenges still need to be addressed before these microswimmers can be widely used in clinical practice.One challenge is the fabrication of microscale helical microswimmers. Femtosecond direct laser writing (fs-DLW) is a powerful tool for fabricating complex 3D structures with high resolution, but it is a slow and inefficient process. This makes it difficult to produce large quantities of microswimmers quickly.Another challenge is the adaptive locomotion of microswimmers in complex environments. Inside the body, pH values vary among different tissues, and numerous microchannels and obstacles exist. Microswimmers need to be able to sense their environment and adapt their locomotion accordingly to reach their target destination.Researchers are addressing these challenges. One approach is to develop new fabrication methods that are more efficient and scalable than fs-DLW. Another approach is to design microswimmers that are more responsive to environmental stimuli and can adapt their locomotion accordingly.In this study, researchers developed a new method for fabricating pH-responsive helical hydrogel microswimmers. This method is called rotary holographic processing and is much faster than traditional methods. It can produce microswimmers in less than a second, approximately one hundred times faster than the point-by-point scanning strategy.The microswimmers are made of hydrogel, which is a type of material that can absorb water. This makes the microswimmers responsive to pH changes. When the pH of the surrounding environment changes, the microswimmers change shape. This shape change allows the microswimmers to move in different ways.Under a constant rotating magnetic field, the microswimmers can tumble or corkscrew. The type of motion depends on the pH of the environment. In a low pH environment, the microswimmers contract and tumble. In a high pH environment, the microswimmers expand and corkscrew.The researchers assessed the microswimmers in various conditions and found that they could traverse complex terrains and deliver drugs to targeted cells. This suggests that rotary holographic processing is a promising method for fabricating microswimmers for biomedical applications.This research suggests that rotary holographic processing is a promising new method for fabricating microswimmers for biomedical applications. The microswimmers are fast, reconfigurable, and able to navigate complex environments. This makes them ideal for targeted drug delivery and cell therapy tasks.newswise.com, 3d ago
SARS-CoV-2 has infected >40% of the world’s population (Collaborators 2022) resulting in a devastating loss of life. As the SARS-CoV-2 pandemic enters its endemic phase (Meng, Irwin et al. 2023, Pilz and Ioannidis 2023), multiple new variants continue to circulate. Since its initial spread, the rapid adaptation of the virus to selective pressures continues to produce variants of concern (VoC), of which the omicron variants presently account for over 90% of current SARS-CoV-2 infections (www.cdc.gov). SARS-CoV-2 displays three structural proteins that are potential targets for therapeutic intervention, but the primary focal point of vaccine development and many therapeutic strategies is the spike surface glycoprotein, which the virus uses to gain cell entry by attaching to the host cell angiotensin-converting enzyme 2 (ACE2) receptor (Jackson, Anderson et al. 2020, Krammer 2020, Letko, Marzi et al. 2020, Polack, Thomas et al. 2020). The spike protein trimer consists of three domains: the receptor binding domain (RBD) on S1 that binds ACE2, the S1 N-terminal domain (NTD) that has a poorly defined function, and the S2 domain that is involved in virus-host cell membrane fusion (Walls, Park et al. 2020, Jackson, Farzan et al. 2022). Glycosylation is most extensive on the NTD and the S2 domain, whereas the RBD is largely glycan free (Watanabe, Allen et al. 2020, Zhao, Praissman et al. 2020). Consequently, it is unsurprising that the most antigenic domain on spike is the RBD, where the vast majority of neutralizing antibodies have been shown to bind. A comprehensive mapping of the epitopes from 1,640 neutralizing monoclonal antibodies (mAbs), all targeting the RBD, revealed 12 epitope groups (Cao, Yisimayi et al. 2022). This data, combined with previous studies mapping the epitopes of antibodies targeting spike, reveal a total of 19 mAb epitope groups, including 7 on the NTD (Wang, Muecksch et al. 2022). Very few anti-S2 antibodies have been shown to be effective therapeutic options (Wec, Wrapp et al. 2020), likely due to the shielding effect of S2 glycans (Grant, Montgomery et al. 2020).elifesciences.org, 25d ago

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Each bottle of the supplement has 30 portions, enough for a month's worth of usage. It comes looking like an effectively dissolved powder that ought to be used with water or some other refreshment. This powder formulation is produced in GMP-certified and FDA-approved facilities to guarantee quality and safety. It uses the best available ingredients. As a matter of fact, the strong Ikaria Slim ingredients are plainly shown in customer reviews. While taking a gander at the Ikaria Slim customer reviews, you may also peruse this article to more deeply study it.Individuals often inquire, "Does Ikaria Slim Really Work?" and "Is it Effective in Breaking Down Fat Cells and Assisting in Weight Loss?" because of the furor around the item. Ikaria Slim has proactively been used by numerous clients, and they have reported a considerable loss of body weight, indicating that the supplement is risk-free and has no adverse consequences. Continue to peruse this article in view of "The Ikaria Slim Reviews 2023", with the goal that you can study it.How does Ikaria Slim work?Now that we've examined the fundamental precepts of the Ikaria Slim level stomach purge recipe, it's chance to determine what advantages it gives and assuming utilizing it has any downsides. We often neglect to check the operating mechanism and wind up buying trick supplements.openPR.com, 3d ago
...“In my discussions with companies that are in the business of the development of AI and its advancement, I have certainly seen just quite immediately, a social consciousness, an understanding of its potential to do great, an understanding of the risks involved, and a very significant desire to advance one and to manage the other,” Mayorkas said.governmentciomedia.com, 3d ago
As technology advances at an exceptional pace, the role of artificial intelligence (AI) has surged significantly. With the continual evolution of the developing technology and its integration into various aspects of our daily lives, concerns regarding its potential hazards have grown louder. Renowned personalities in this new space, including Geoffrey Hinton and Elon Musk, have sounded the alarm concerning the potential consequences of unchecked AI advancement. This article titled Why is AI Dangerous and What are the Dangers of AI?’ explores into the complex range of dangers that AI poses and find out strategies to mitigate these challenges.Techiexpert.com, 3d ago

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More than ever, scientists need new technologies to help solve many of the most pressing issues facing society like reversing climate change, addressing food insecurity, and developing lifesaving therapeutics. Fundamentally, these problems are chemistry and materials science challenges, and some will require the transformational power of a scaled quantum computer. While we are on a path to engineer a quantum supercomputer, we are also making investments in High-performance computing (HPC) and Artificial intelligence (AI) to empower researchers to accelerate scientific discovery and make rapid progress toward impactful solutions for our most pressing problems today.Chemistry World, 3d ago
Substantial effort has been devoted to investigating the health applications of neurostimulation, a therapeutic intervention whereby electromagnetic signals are used to disrupt pathological patterns of neural activity associated with brain disease and induce new healthier patterns. However, while neurostimulation has been shown to effectively treat many neuropsychiatric disorders, the underlying mechanisms of action remain poorly understood, and as such, neurostimulation’s full utility as a health intervention has yet to be realized. McKinley aims to apply these insights to develop a nonlinear dynamical theory of neurostimulation, with the goal of informing precise and individualized neurostimulation treatment. By generalizing to the case of time-dependent neurostimulations, the theory will elucidate the underlying dynamical principles of neurostimulation, maximizing its safety and efficacy as a health intervention as well as minimizing side effects and uncertainty of treatment outcomes, honing a new tool for healing the brain. This research has implications for a wide range of brain-based diseases, including neurological diseases such as Parkinson’s and Alzheimer’s, epilepsy, tinnitus, and chronic pain, and psychiatric disorders including major depression, obsessive compulsive disorder, generalized anxiety, post-traumatic stress disorder, bipolar disorder, and psychosis. Resulting work from this research will give clinical neuroscientists the precision to prescribe treatments based on the needs of individual patients according to their unique neural makeup and specific pathologies and will allow tailored treatments that maximize efficacy and safety while minimizing side effects and risk, improving treatment outcomes, and setting the foundation for future neuroscience research investigating brain health.newswise.com, 3d ago
The interaction of elastic and electronic properties also is in the focus of the DFG-funded Transregio project ELASTO-Q-MAT, in which MPI CPfS and KIT are the main project partners. For the study published in Science, KIT researchers developed a model of the effect that is caused by a few current-carrying electrons that soften the material. The corresponding measurements were made at MPI CPfS in Dresden. “Ilya M. Lifshitz’s theory is not wrong,” Schmalian points out. “But our study offers a new perspective and opens up the possibility to manipulate strong quantum fluctuations in the lab and to optimize materials for a certain physical effect.”...newswise.com, 3d ago
ChatGPT is not the end game, though, according to Jianfeng Feng, dean of the Institute of Science and Technology for Brain-Inspired Intelligence at Fudan University. In his commentary, “Simulating the whole brain as an alternative way to achieve AGI,” Feng argued that the ability of ChatGPT to outperform humans in certain tasks is not surprising — after all, a simple calculator can multiply large numbers quicker than a human. However, it is not an example of artificial general intelligence (AGI), a theoretical step beyond AI that represents human abilities so well it can find a solution for any unfamiliar task.SCIENMAG: Latest Science and Health News, 3d ago
Our article describes what happens when a desert-adapted mouse in a simulated desert habitat is without access to water. It provides us a unique opportunity to explain the survival strategies employed by organisms in some of the harshest habitats on Earth. Desert mammals have been studied quite extensively for the last 100 years and given the current climate change reports, understanding environmental tolerance and the capacity for adaptation in one species can provide insight into the potential for similar species to respond to increasingly extreme climatic patterns that are likely to affect many habitats. We explored the physiological mechanisms that enable cactus mice to survive in desert habitats using long-term physiological data, observing that cactus mice have unique and important responses when water deprived. Without water they have significantly lower metabolisms, leading to reduced water loss compared to mice with access to water. They also lose a significant amount of weight, likely due to reduce food intake aimed at limiting fluid loss by reducing waste and the solute load, while facilitating water reabsorption.The Company of Biologists, 3d ago
Fueled with the trend of nearshoring, micro-factories could potentially take off in the next few years pending the adoption of IT cloud infrastructure manufacturers. With the rise of automation and AI on the plant floor, manufacturers can rely on these technologies to increase production efficiency and quickly scale operations. At the heart of any successful modern factory is a modern cloud infrastructure to swiftly deploy automation and 3D printing operations. A cloud solution helps manufacturers manage the numerous digital elements in a modern factory. Moreover, there is end-to-end visibility on the shop floor and beyond, allowing leaders to make informed business decisions in real-time based on data insights. Complex factories’ success relies on the cloud to monitor the complexity associated with high volumes of output. A cloud infrastructure also provides leaders with the flexibility to manage an unprecedented supply chain. Without the cloud, a modern factory does not have the ability to scale and customize products to meet consumer needs.Design and Development Today, 3d ago

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Our model aims to describe the early stages of the evolution of life on Earth based on non-enzymatic polymerization. While it may seem challenging to test it for conditions relevant to the origin of life, our main conclusions can still be verified experimentally. RNA or DNA can be used as model polymers in such experiments, as both have demonstrated catalytic abilities in cleavage reactions [10–15]. To simulate primordial polymerization driven by day/night cycling, the experiment would have to rely on enzymatic polymerization or ligation as used e.g. in Polymerase Chain Reaction (PCR) [37, 38] or Ligase Chain Reaction (LCR) [39]. However, it’s important to note that our model assumes polymerization in both the 5’-to-3’ and 3’-to-5’ directions, unlike traditional PCR, which only adds new nucleotides in the 5’-to-3’ direction. This problem of bidirectional polymerization was solved by evolution using Okazaki fragments[40]. Inspired by this discontinuous synthesis of the lagging strand of DNA, we propose a possible experimental implementation of our system based on ligation rather than polymerization enzymes. In this scenario, the system would be supplied with ultrashort random DNA segments. These segments, which are much shorter than the minimal primer length (l0), would play the role of “monomers” and bidirectional primer extension would occur through a sequence of ligation steps connecting adjacent ultrashort segments to each other. Another important consideration for experimental implementation is the need to activate the nucleotides to provide free energy for polymerization. Thus, both the short fragments supplied to the system and the new primers formed by cleavage must be chemically activated.elifesciences.org, 3d ago
ATXN3 has been reported to play an important role in the development and progression of multiple types of cancers, including breast cancer (53, 54), anaplastic thyroid carcinoma (55), testicular cancer, and non–small cell lung adenocarcinoma (56, 57), in a tumor cell–intrinsic manner. Together with our discovery that ATXN3 drives tumor evasion of immunosurveillance through promoting PD-L1 transcription, targeting of this druggable enzyme will achieve both chemo- and immune-therapeutic efficacy in antitumor treatment. Since ATXN3 promotes PD-L1 expression through STAT3 and HIF-2α, it will be interesting to test whether ATXN3 inhibition synergizes with STAT3- and HIF-2α–specific inhibitors in suppressing tumor growth, which could provide useful insights in translational studies. We are also aware that STAT3, IRF1, and HIF-2α play important roles in immune cells including T cells and myeloid cells, suggesting a potential impact of systemic ATXN3 inhibition in antitumor treatment. While studies report the phenotypic analysis of ATXN3 germline KO mice, which are viable and fertile, there have been no reports of any inflammatory or immune-deficient responses (58). However, the possibility that targeting ATXN3 in non-cancer cells may alter immune functions as a result of accelerated STAT3, IRF1, and HIF-2α degradation cannot be excluded. Future studies are needed to develop ATXN3-specific small-molecule inhibitors for this purpose.jci.org, 3d ago
Ocean acidification (OA), a consequence of the increase in anthropogenic emissions of carbon dioxide, causes major changes in the chemistry of carbonates in the ocean with deleterious effects on calcifying organisms. The pH/PCO2 range to which species are exposed in nature is important to consider when interpreting the response of coastal organisms to OA. In this context, emerging approaches, which assess the reaction norms of organisms to a wide pH gradient, are improving our understanding of tolerance thresholds and acclimation potential to OA. In this study, we deciphered the reaction norms of two oyster species living in contrasting habitats: the intertidal oyster Crassostrea gigas and the subtidal flat oyster Ostrea edulis, which are two economically and ecologically valuable species in temperate ecosystems. Six-month-old oysters of each species were exposed in common garden tanks for 48 days to a pH gradient ranging from 7.7 to 6.4 (total scale). Both species were tolerant down to a pH of 6.6 with high plasticity in fitness-related traits such as survival and growth. However, oysters underwent remodelling of membrane fatty acids to cope with decreasing pH along with shell bleaching impairing shell integrity and consequently animal fitness. Finally, our work revealed species-specific physiological responses and highlights that intertidal C. gigas seem to have a better acclimation potential to rapid and extreme OA changes than O. edulis. Overall, our study provides important data about the phenotypic plasticity and its limits in two oyster species, which is essential for assessing the challenges posed to marine organisms by OA.The Company of Biologists, 3d ago
While there is emphasis and acknowledgement of the role of the family in health, the absence of family perspectives is most perplexing in the realm of family nursing. This prompted me to examine the following questions in this doctoral research: What are the family members’ perceptions of the extent of family support (i.e., cognitive, and emotional support)? What are the nurses’ perceived extent of nursing practice with families? While answering these questions, the extent of nurses and family members´ perspectives on family nursing framed opportunities for exploration of nurse-led interventions for supporting families in the trajectory of acute care.What are the key findings or observations of your doctoral research?Among the main findings of my doctoral research, I illustrated the application of polychoric correlations and polychoric confirmatory factor analysis as a valid alternative statistical approach using data on family members’ perceived support from nurses as an exemplar. We showed that polychoric correlation gives stronger associations, and consequently, the approach can be more credible for ordinal Likert scales commonly used in nursing research. We identified that there was controversial evidence on the impact of diaries in improving family outcomes in critical care settings. Due to the few studies identified, there was very little ability to make strong recommendations on the effectiveness of nurse-led FN interventions to support families in critical care settings. A single-group before-and-after quasi-experimental design of a family strength-based nursing intervention showed positive differences in family outcomes (cognitive and emotional support) and nurses’ skills in working with families in critical care settings but not nurse–family relationships.How can the results of your doctoral research be utilised in practice?This study provided insights into the specific perspectives of healthcare service users, that is, family members and healthcare service providers (nurses), on the family. Together, these perspectives enrich three central concepts of the nursing metaparadigm: the person/family receiving nursing care, health, and nursing, particularly in the field of family nursing. The results also highlight and emphasize the potential of considering polychoric CFA as an alternative statistical approach that can be used to examine Likert measurement tools in nursing science. In addition, a new perspective on family support interventions was explored – the family strengths-based nursing intervention was examined. The intervention leverages structural and functional family-system components, specifically family strengths, to promote nursing actions for supporting families in acute care settings. This intervention can be developed further as a guiding framework that nurses can utilize to support family members in acute care settings.What are the key research methods and materials used in your doctoral research?The study was conducted in two phases each with distinct research methods. In the first phase, a cross-sectional design was used. This was conducted among a sample of family members (n=800) and nurses (n=460) from two Uganda tertiary hospitals. The Icelandic Family Perceived Support Questionnaire (ICE-FPSQ) was utilised for collecting data from patients’ family members while the Family Nursing Practice Scale was used to collect data from the nurses. The two questionnaires were being used in the setting for the first time thus, before their use, assessment of their validity for use in the setting was conducted. The data from the cross-sectional was mainly quantitative given the nature of the instruments.University of Eastern Finland, 3d ago
Although the term ‘liquid biopsy’ first entered the cancer lexicon less than 15 years ago, this approach is now just beginning to establish a strong foothold in clinical practice, particularly in non-small cell lung cancer (NSCLC) due to the growing range of druggable oncogene drivers. Currently, the main clinical application is analysing circulating tumour DNA (ctDNA) in patients with EGFR-mutated NSCLC, commonly where there is insufficient tumour tissue, and most often in those who have progressed on targeted therapies. The non-invasive nature of liquid biopsies, and their consequent potential to be repeated easily, provides the means to monitor resistance development during therapy. However, in reality, the use of liquid biopsies is shaped by cost and lack of reimbursement, particularly in Asia. When some form of ctDNA analysis is available, use may be limited to one test with a single-gene PCR-based assay rather than serial testing with next-generation sequencing, and the question arises regarding the optimal time to take this opportunity. Improving affordability may lead to increasing use of the ‘plasma first’ approach rather than merely being an alternative where tissue samples are unavailable or inadequate. Going forward, it will also be critical to develop panels that are appropriate to the clinical setting rather than using whatever is available, as is often the case in current practice.Daily Reporter, 3d ago
..."It is a big logistical challenge to know how these materials can find new homes without inefficient and costly transportation and storage," Johns added. He and his co-authors hypothesized that this problem might also be solvable if they designed an autonomous robot with the tools to record and store the specifications of materials.American Association for the Advancement of Science (AAAS), 3d ago

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Address racialized disparities in applicant review through counterbalancing. Given that committees cannot not evaluate grantsmanship, productivity, and institutional type, it's important to develop ways to address these areas without reproducing the durable disparities associated with them. Two proven methods are balancing within criteria and balancing between criteria. Balancing within criteria means integrating equity parameters within selection criterion, such as the use of culturally relevant pedagogy when evaluating teaching, experience with and quality of mentoring racially minoritized students, and other possibilities as described by Liera and Ching (2019). Balancing between criteria means manipulating the order and weight of criteria such that one factor does not outweigh others. This could mean reducing the emphasis on grantsmanship, or evaluating it after evaluating important diversity, equity, and inclusion (DEI) criteria, as is the case with UCLA’s mentor professor program that has led to the successful hire of multiple excellent faculty of color.upenn.edu, 3d ago
Mutational effects on protein stability have important consequences for evolution. Destabilized proteins misfold more often, which can attenuate their ability to function in the cell (4, 17). Though natural selection typically maximizes fitness by incorporating mutations that produce new or improved functions, this optimization process is often hindered by the destabilizing effects of most random mutations (4, 39). The cumulative energetic effects of these mutations on protein stability are generally capable of creating non-additive, context-dependent epistatic interactions (10, 26, 36). Nevertheless, there are many different aspects of protein synthesis, folding, and assembly that are governed by distinct energetic constraints. While epistatic interactions arising from changes in protein stability have been previously characterized in soluble proteins (Gong et al. 2013; Olson et al. 2014; Faber et al. 2019; Nedrud et al. 2021), the impact of epistasis on membrane protein folding and stability has yet to be explored. Although many of the mechanistic underpinnings of pairwise epistasis in soluble proteins are likely to be generalizable to all proteins, membrane proteins undergo additional cotranslational folding reactions that are governed by mechanistically distinct kinetic and energetic constraints (17, 31). Based on these considerations, we suspect that mutations in membrane proteins could potentially modify cotranslational processes in a manner that generates distinct epistatic interactions that bias their evolutionary pathways in unique ways.elifesciences.org, 3d ago
Why are sensing gravity, negative gravitaxis and righting behavior adaptive for monarchs? One possible ecological explanation is that gravity cues play a key role for flight take-off. Righting behavior (whether righting themselves or maintaining a head-up position) can first help monarchs be in a more advantageous physical position, across a variety of contexts, but specifically for flight readiness. An initial hurdle in flight kinematics is the ability to generate enough acceleration to initiate flight. Butterflies (Bimbard et al., 2013), other insects (Burrows et al., 2019) and birds (Heppner and Anderson, 1985) have been shown to overcome this first hurdle by initially leaping into the air followed by wing flapping. It is possible that monarchs are looking to increase their physical elevation prior to this initial leap. Both migratory and non-migratory monarchs can utilize this technique for initiating flight by jumping from a higher location. In support of this possible function, we observed that some monarchs had initiated flight upon successfully reaching the top of the mesh tube in our trials. Another ecological explanation for negative gravitaxis could be related to thermoregulation. Monarchs have been observed to utilize the sun to warm up their flight muscles prior to flying (McCord and Davis, 2010). By walking upward on a substrate, monarchs can reach higher locations with less cover to bask in the sun under natural conditions. This behavior would be especially helpful during cooler months, such as late autumn and early spring, when monarchs undertake their migratory journey, and during early mornings when temperatures are typically lower. Finally, monarchs can use gravity as a reliable cue for directional information and oriented movement as it is an ever-present cue in the environment throughout the day (both day and night), can be used irrespective of current weather conditions (unlike sun visual cues that can be occluded during overcast conditions), and does not require sensory input from other modalities (unlike light-dependent magnetosensation – Guerra et al., 2014; Wan et al., 2021).The Company of Biologists, 3d ago

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Behavioural research has garnered an increasing profile since covid, but the study of behaviour is crucial not just for health but also finance, sustainability and many other challenges facing the world. This hub gives us the opportunity to bring together researchers across the UK, to make the most of our excellent behavioural research and researchers. It is exciting to be part of this ambitious attempt to improve our science and practice...New £10 million hub for behavioural research, 24d ago
Neural oscillations are thought to play an important role in coordinating neural activity across different brain regions, allowing for the integration of sensory information, the control of motor movements, and the maintenance of cognitive functions. Thus, better methods to detect and characterize neural oscillations, especially those that are asymmetric, can greatly impact neuroscience. In this study, we present Cyclic Homogeneous Oscillation (CHO) as a method to reveal the “when”, the “where”, and the “what” of neural oscillations. With this method, we overcome the confounding effect of detecting spurious oscillations that result from harmonics of the non-sinusoidal neural oscillations (Donoghue et al., 2022). In our study, we demonstrate that solving this problem yields scientific insights into local beta oscillations in pre-motor areas, the onset/offset of oscillations in the time domain, and the fundamental frequency of hippocampal oscillations. These results demonstrate the potential for CHO to support closed-loop neuromodulation (brain-computer interfaces and neurofeedback) and neural oscillation detection systems to implement various neurological diagnostic and therapeutic systems and methods.elifesciences.org, 17d ago
Abstract: Hematologic processes are frequently comprised of cellular and biomolecular interactions that are biophysical in nature and may involve blood cells (erythrocytes, leukocytes, and platelets), endothelial cells, soluble factors (coagulation proteins, von Willebrand factor, and cytokines), the hemodynamic environment, or all of the above. These phenomena are often pathologically altered in hematologic diseases but are difficult to study using standard in vitro and in vivo systems. With the capabilities to dissect cellular and biomolecular phenomena at the micro to nanoscales with tight control of the mechanical and fluidic parameters, micromechanical and microfluidic systems can serve as novel yet physiological in vitro disease models to provide insight into the pathophysiology of blood disorders. Due to their inherent portability, these microsystems can also be translated into diagnostic tests used at the point-of-care or even by patients at home, especially if those technologies are coupled to existing consumer-based devices like smartphones. Recently, our lab has also developed open source software for the entire field to analyze blood-based microfluidic data more easily as well as embark on developing combined microfluidic and analytical strategies to help improve the efficiency and lower the cost of cellular therapies for hematologic diseases. By developing state-of-the art microdevices to answer hematologic questions, microsystems engineering has the potential to significantly advance our understanding of blood disorders and to develop innovative diagnostic and therapeutic strategies for patients afflicted with those life-threatening diseases.gatech.edu, 12d ago
Abstract: Controlling magnetism with voltage has an enormous potential to boost energy efficiency in nanoscale magnetoelectric devices since the use of electric fields (instead of magnetic fields or electric currents) minimizes Joule heating effects and reduces the overall device power consumption. In recent years, we have demonstrated the possibility to induce reversible, non-volatile changes in the magnetic properties (coercivity, remanent magnetization and saturation magnetization) of nanoporous films consisting of metal alloys (e.g., CuNi, FeCu) or oxides (e.g., FeOx, CoFe2O4), by applying an electric field through a liquid electrolyte gate at room temperature [1,2]. In addition, we have made significant progress in the field of magneto-ionics (i.e., voltage-driven ion transport in magnetic materials), which has traditionally relied on controlled migration of oxygen or lithium ions. Here, I will show that voltage-driven transport of nitrogen ions can be also triggered at room temperature in transition metal nitride (CoN, FeN, CoMnN and CoFeN) films via liquid electrolyte gating [3,4]. Nitrogen magneto-ionics can induce reversible ON-OFF transitions of ferromagnetic states at faster rates and lower threshold voltages than oxygen magneto-ionics. This is due to the lower activation energy needed for ion diffusion and the lower electronegativity of nitrogen with cobalt, compared with oxygen. Remarkably, and in contrast to oxygen magneto-ionics, nitrogen transport occurs uniformly through a plane-wave-like migration front, without the assistance of diffusion channels, which is particularly interesting for the implementation of multi-stack memory devices. Furthermore, we will show that both oxygen and nitrogen magneto-ionics can be used to emulate some important neuromorphic/synaptic functionalities (spike amplitude-dependent plasticity, spike duration-dependent plasticity, long term potentiation/depression). By tuning ion cumulative effects of DC and pulsed voltage actuation (at frequencies in the range 1 – 100 Hz), learning, memory retention, forgetting and self-learning by maturity (post-stimulated learning) can be mimicked. The latter can serve as a logical function for the device to decide between self-learning or forgetting emulation, at will, post-voltage input. This constitutes a novel approach to emulate some specific neural functionalities (e.g., learning under deep sleep), that are challenging to achieve using other classes of materials currently employed for neuromorphic computing applications.icn2.cat, 4d ago
While the potential of blockchain technology is immense, it is not without its challenges. Scalability, regulatory uncertainties, and the energy consumption of some blockchain networks are among the hurdles that need to be addressed. However, ongoing research and development are actively seeking solutions to these challenges, indicating a promising future for blockchain innovations.TechBullion, 13d ago
Researchers hope that AI can assist in expeditiously identifying and classifying traumatic abdominal injuries. “The artificial intelligence models developed as part of this challenge have significant potential to advance patient care by assisting radiologists and other physicians to detect and grade different traumatic abdominal injuries, which is a particularly difficult task, requiring a lot of careful image review,” said Jeff Rudie, MD, PhD, emergency radiologist and Scripps Clinic and adjunct assistant professor in the Department of Radiology at the University of California, San Diego. “These models may have the potential both to help prioritize positive studies for faster reading and to identify higher grade injuries that might require prompt intervention.”...rsna.org, 9d ago

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Overall, this is just the beginning for NVIDIA. While Jetson and the other solutions are exciting and have had a positive impact, there’s a lot more to be done. The company is already looking at new ways to help its customers access better data, make better decisions and solve their most pressing problems. Much of what NVIDIA is doing now is focused on crunching information from huge databases in order to extract the insights farmers need to minimize chemical inputs, forecast yield and harvest efficiently without additional labor.precisionfarmingdealer.com, 3d ago
Temporal dynamics of odour encounters depend on both the spatio-temporal structure of the odour environment and the way in which an organism moves, interacts and potentially reformats its olfactory surrounding (Crimaldi et al., 2021; Lei et al., 2022). Peripheral olfactory circuits allow the fast temporal encoding of intermittency and fluctuations in odour concentration (Egea-Weiss et al., 2018; Lemon and Getz, 1997; Szyszka et al., 2014) which have been shown to tune the neural activity in the antennal lobe (Huston et al., 2015; Lei et al., 2009; Martelli and Fiala, 2019) and were suggested to improve up-wind odour-source localisation (Lei et al., 2009; Willis and Baker, 1984). In addition to natural fluctuations, animals often display small oscillatory movements on top of their primary task-related trajectories (Chen et al., 2020; Liberzon et al., 2018; Willis and Avondet, 2005), which are intensified with novel stimuli detection (Huston et al., 2015; Loudon and Koehl, 2000; Schmitt and Ache, 1979). These behaviours enhance odour reception by imposing frequency-dependent fluctuations and creating sharp odour onsets at the olfactory organs, thus entraining odorant–receptor interactions (antennule ‘flicking’ in lobsters: Koehl et al., 2001; wing-flapping in flying insects: Li et al., 2018; Loudon and Koehl, 2000; Tripathy et al., 2010; and antennal movement: Claverie et al., 2022; Huston et al., 2015). In addition, olfactory processing may be modulated via specific neural circuitry projecting from motor networks to olfactory processing centres, further indicating that the movement itself could entrain odour encoding (Bradley et al., 2016; Chapman et al., 2017, 2018). We show here that cockroaches not only display comparable odour-induced modulations of antennal movement (Fig. 5) but also that these can impact the spatio-temporal structure of the odour environment (Fig. 6; Fig. S4). This could be of particular importance in low-turbulence and low-odour intermittency environments where cockroaches typically dwell. These elements can be paralleled with mammalian sniffing (Verhagen et al., 2007). During sniffing, the sharp input events, created through the rapid flow of odorants into the nasal cavity, have been shown to enhance odorant detection and discrimination (Kepecs et al., 2007; Oka et al., 2009). The sniffing frequency is controlled on a cycle to cycle basis according to task, the complexity of the olfactory environment and the animal's internal state (Verhagen et al., 2007), and increases upon odour encounter (Bhattacharjee et al., 2019; Reisert et al., 2020). At low to intermediate sniffing rates, intermittency in odour concentration allows receptor neurons to recover from adaptation during the intervals between successive inhalations Wachowiak (2011). With increases in sniffing frequency, seen during active exploration, signal attenuation also increases, resulting in enhanced contrasts for target odorants (temporally dynamic or spatially localized) against the broadly distributed background odours (Verhagen et al., 2007; Wachowiak, 2011). Additionally, and similar to motor-to-sensory neural pathways in insects (Chapman et al., 2018), there is evidence that the breathing rhythm itself could act as a coupling mechanism between neural networks (Karalis and Sirota, 2022). Parallels in the functional neural architecture of different olfactory systems (Strausfeld and Hildebrand, 1999; Touhara and Vosshall, 2009) further suggest that movement-driven temporal patterning in arthropods could similarly impact odour coding in a frequency-dependent manner.The Company of Biologists, 3d ago
One of the major challenges of online sales — both for businesses and shoppers — has always been the lack of that authentic ‘touch and feel’ experience. But technology is not standing still, and augmented reality (AR) has already addressed this challenge. While AR is not at its full tech capacity yet, many retail businesses already use its potential to revolutionize sales. Below, we will take a look at the main reasons why AR has the power to reshape sales, list a few businesses that already implement this technology in their marketing efforts, and give a few tips and future predictions for boosting sales with the help of AR — because make no mistake, AR is one of those sales trends that are here to stay.Rebellion Research, 4d ago
In Politically Animated, Iexplore the convergence of animation and actuality within films, television series, and digital shorts from across the Spanish-speaking world. I interrogate many of the ways in which animation as a stylistic tool and storytelling device participates in political projects that underpin an array of non-fiction works. The phrase “politically animated”refers to, on the one hand, the ideological implications of employing specific techniques and styles of animation within certain socio-historical and cultural contexts, and, on the other hand, the fact that it is a political project that inspires or moves the film and television director or digital content creator to action. By paying particular attention to cultural production beyond the realm of cinema, my book continues to stretch the bounds of current animated documentary scholarship, just as it does by pointing to animated journalism and the animated essay as relatively new and definitively exciting areas of study within this burgeoning field that has now seen two full decades of fruitful investigation. That the focus of Politically Animated is on the Hispanic world also works to rectify an anglocentrism that has largely characterized the field to date. In order to make my book as widely accessibly as possible to the field, I have consistently translated into English the many Spanish-language film titles and quotes, as well as non-English scholarly criticism.University of Toronto Press, 4d ago
Building on earlier research published by CIGI on the space-cyber nexus, the authors find that there is not one “grey zone” in space governance, but a cluster of nebulous governance challenges that are set to grow as our use of outer space not only expands but evolves in unexpected ways. The ultimate challenge, then, is to colour in governance frameworks so that less grey — less ambiguity — remains. In this paper, the authors peel back the layers of opacity that shroud the grey zone to reveal some of these unsettled governance issues that give rise to it, expand its scope and result in hidden harms. The analysis flows from the military concept of grey zone tactics to an identification of three entangled governance challenges. Stronger governance measures are needed, and the paper concludes by outlining opportunities for providing some colour in the grey zones of space governance by clarifying the parameters and rules of peaceful uses of outer space, making space activities and their potential harms more visible, and pursuing cross-domain governance discussions.Centre for International Governance Innovation, 4d ago
High Content Screening (HCS) is a technique used in drug discovery and development process that combines automated microscopy, imaging, and informatics tools to analyze large sets of chemical compounds or molecular entities. It enables researchers to understand the biological functions and interactions of potential drug candidates with greater accuracy and efficiency. High Content Screening offers various use cases, such as studying cellular processes, identifying drug targets, toxicity testing, and personalized medicine.Medgadget, 4d ago

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To conclude, I think this line of research on cultures of peace, which my colleague Chris Coyne (2023) has embarked upon on the heels of developing an extensive research program in defense and peace economics (see Coyne 2007; 2013; Coyne and Hall 2018; 2021), represents a great opportunity to tie up all these areas I have referenced—institutions, ideas, and their interaction; development, historical political economy, and PPE—to address the serious social problems we face today with increased divisions in society, with the resurgence of populism on both left and right, and a general loss of faith in the possibility of progress. In founding the Thomas Jefferson Center, Buchanan argued that economists must learn the technical principles of price theory to be able to assess the impact of alternative institutional arrangements of the ability of individuals in those societies under examination to pursue productive specialization and realize peaceful social cooperation. But he also said that the political economist must also be willing to ask the philosophical questions that such analysis of comparative institutions raise related to liberty, peace, prosperity and “goodness”. These are what the founders of public choice sought to encourage in the dialogue among economists, political scientists, philosophers, and historians at those early meetings. Furthermore, as the arguments developed in the subsequent decades Buchanan repeatedly asked us to think about whether we can avoid falling prey to the Hobbesian jungle—in short can we find freedom in constitutional contract. While deeply sympathetic to that exercise, Vincent Ostrom nevertheless repeatedly asked us to contemplate if we can in fact successfully manage this Faustian bargain we are compelled to make. Remember in the play, Faustus does not repent, though he has several opportunities to do so, and the play ends with Faustus being dragged off to Hell by demons.Econlib, 27d ago
Arcata, California, is a charming coastal town nestled along the beautiful Humboldt Bay and is known for its picturesque landscapes and vibrant community. In Arcata, homeowners often embrace eco-friendly practices, including sustainable gardening and energy-efficient home improvements, to care for their homes and the environment. One of the most effective ways to maintain the beauty and longevity of your home is through the skillful application of paint and stain. Whether you’re looking to refresh your home’s exterior, update its interior spaces, or protect your wooden fixtures from the elements, a handyman Arcata, CA, can make a difference. This article will look at the various aspects of painting and staining, from choosing the right colors and materials to applying techniques that can transform your home. So, let’s dive into the art of painting and staining and discover how it can breathe new life into your living spaces.GIS user technology news, 11d ago
About AFAR – The American Federation for Aging Research (AFAR) is a national non-profit organization that supports and advances pioneering biomedical research that is revolutionizing how we live healthier and longer. For more than four decades, AFAR has served as the field’s talent incubator, providing nearly $199 million to some 4,400 investigators at premier research institutions to date—and growing. In 2023, AFAR expects to provide approximately $12,500,000 to more than 60 investigators. A trusted leader and strategist, AFAR also works with public and private funders to steer high quality grant programs and interdisciplinary research networks. AFAR-funded researchers are finding that modifying basic cellular processes can delay—or even prevent—many chronic diseases, often at the same time. They are discovering that it is never too late—or too early—to improve health. The science funded by AFAR is paving the way for innovative new therapies that promise to improve and extend our quality of life—at any age. Learn more at www.afar.org.SCIENMAG: Latest Science and Health News, 24d ago

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Join us for an informative and exciting graduate school visit with MIT Center of Brains, Minds and Machines. Whether you are a prospective graduate student or simply interested in the intersection of brains, minds and machines, this session is the perfect opportunity to discover all that MIT has to offer. Don't miss out on this unique opportunity to explore one of the world's leading institutions for research and education in the field of neuroscience.UCF Events, 4d ago
The bioeconomy brings opportunities for economic growth while tackling climate change. Fossil carbon resources can be replaced by bio-based carbon resources, especially biomass. To allow these solutions to be scaled up without threats to biodiversity and the environment, it is necessary to develop the bioeconomy as a circular economy. With this carbon management approach, other sources of carbon complement biomass: industrial waste, including gases such as CO and CO2, as well as physically and chemically recycled carbon. In the future, direct air capture (DAC) may become competitive and form part of the solution. These approaches can be considered ‘circular’ because they close material loops and keep carbon recycling in the economy rather than emitting carbon to the atmosphere. This report reviews a number of hybrid technologies that can be deployed to ‘defossilise’ economic sectors and sets out policy options to bring these technologies to commercial scale.oecd-ilibrary.org, 4d ago
Newswise — A new AI-assisted molecular diagnostic platform capable of identifying variants of COVID-19 and other infectious diseases has been developed by scientists in the UK. The low cost, portable device could play a crucial role in preventing future pandemics due to its accuracy and versatility.Scientists from the University of Surrey, Brunel University London, and Lancaster University in collaboration with the NHS, GB Electronics (UK) Ltd and Vidiia Ltd, have created the platform known as VIDIIA Hunter (VH6). It uses reverse transcription loop-mediated isothermal amplification (RT-LAMP) technology in combination with an artificial intelligence (AI)-based deep learning model. The AI model has been trained to read the results of tests identifying infectious diseases, including COVID-19 and removes users’ interpretation and errors whilst improving accuracy.Professor Roberto La Ragione, Professor of Veterinary Microbiology and Pathology at the University of Surrey, said:“Lateral flow tests are an efficient way of testing if you have COVID-19, however, there has always been a question mark over their accuracy which has only been heightened with the emerging number of variants now in circulation. As COVID-19 continues to evolve, we need to evolve with it and have highly accurate tests that can be readily used without the need for laboratory facilities.”To confirm the accuracy of VH6 scientists tested 150 COVI-19 positive clinical nasal swabs with a range of viral loads and 250 negative samples provided by NHS Berkshire, Surrey Pathology and Royal Lancaster Infirmary, Lancaster. The test was found to be highly accurate with a detection rate of 98 percent and a specificity of 100 percent. Additional testing found the device detected all the COVID-19 variants that have circulated in the UK since December 2020.Dr Aurore Poirier, first and co-corresponding author of the study and Research Fellow B at the University of Surrey, said:"The VH6 diagnostics platform has been approved for COVID-19 testing in the UK, but also has to potential to diagnose current and emerging infectious disease and antimicrobial resistance. Its portability, rapidity, accuracy, and affordability allow for near patient testing, in all laboratory and healthcare settings, including low-resources ones. The VIDIIA Hunter therefore has the potential to help control future outbreaks."To monitor and track the spread of COVID-19 and other infectious diseases, the test is connected to a smartphone app that allows an operator to manage and track the patients and samples. Results and graphs are displayed on the app in as little time as 20-30 minutes and automatically connects to a cloud. The platform allows near-patient testing and has the potential to detect other infectious diseases such as tuberculosis and dengue fever, and antimicrobial resistance.Unusually, the test can be used for human and animal healthcare which is a crucial step in identifying any future zoonotic diseases which could spread between the two.Professor Muhammad Munir, Professor of Virology and Viral Zoonosis at Lancaster University said,“Incorporation of LAMP technology with advanced modules of AI has empowered the earliest, reliable and economical detection of infections, including COVID-19, and holds potential for the detection of diseases in both humans and animals, making it a tool of significant medical importance.”The VH6 has now been approved for medical use in the United Kingdom under the UK Health Security Agency’s Medical Devices (Coronavirus Test Device Approvals, CTDA) Regulations 2022 and is CE-IVD marked and MHRA registered.A study using this diagnostic platform has been published in Frontiers in Molecular Biosciences.newswise.com, 4d ago
Newswise — ROLLA, Mo. – Imagine owning a library with every book imaginable — millions and millions of titles — but not having a way to organize the different texts or search for specific information.This is essentially the scenario Missouri University of Science and Technology researcher Dr. Satish Puri works to fix, but instead of it being a brick-and-mortar library filled with books, he is working with petabytes of digital data — primarily geospatial information, such as maps — and finding the best ways to run queries and get useful results as quickly as possible.To put the term “petabyte” into perspective, Puri, an associate professor of computer science, says one petabyte equals 1 million gigabytes. Each gigabyte is equivalent to 1 million kilobytes (KB). The first commercially available floppy disks, which can be considered a precursor to memory cards or USB flash drives, could store 80 KBs.Puri says different types of maps often need to be combined to answer queries, and the map data he works with includes a collection of spatial shapes and location markers.“The amount of spatially referenced data now available may be difficult for some people to fully conceptualize, especially when you consider the available sources, such as smartphones, drones and remote sensing satellites,” he says.But with these massive datasets comes the need to be able to effectively use them, which is why Puri was awarded a grant from the National Science Foundation’s Faculty Early Career Development (CAREER) Program last year. His project, which is expected to receive over $500,000 over the course of five years, is titled: “Communication-efficient and topology-aware designs for geospatial analytics on heterogeneous platforms.”Earlier this year, he was also awarded a $230,000 three-year NSF grant for a project titled “Approximate nearest neighbor similarity search for large polygonal and trajectory datasets.” Both projects focus on geospatial analytics.For these projects, Puri is creating algorithms and using high-performance computing with graphics processing units and smart network interface cards that have advanced processing capabilities and allow searches to be conducted faster.“Just think about some of the basic searches you may do while traveling,” he says. “Your phone can map out driving directions and show the top restaurants in your area, as well as the nearby cities, lakes, roads and different camera views, among other datasets. These basic examples fit with my research, but my projects are even more complex.”Puri says he is developing algorithms that can use data for everything from geophysical trends and solar physics all the way to social issues that can be documented and analyzed in maps.For example, climate scientists could potentially use his developments to more effectively monitor the melting of polar sea ice. During the COVID-19 pandemic, his algorithms could have provided more efficient ways to tie in multiple maps and determine disease hotspots related to the virus and its spread.He says his work will eventually be incorporated into publicly available software for mapping and analytics, and it will most often be used by members of the scientific community and federal agencies.“Working with big data can lead to some big challenges,” he says. “But my research should eventually make a big difference.”For more information about Missouri S&T’s computer science department, visit cs.mst.edu.About Missouri University of Science and TechnologyMissouri University of Science and Technology (Missouri S&T) is a STEM-focused research university of over 7,000 students located in Rolla, Missouri. Part of the four-campus University of Missouri System, Missouri S&T offers over 100 degrees in 40 areas of study and is among the nation’s top public universities for salary impact, according to the Wall Street Journal. For more information about Missouri S&T, visit www.mst.edu.newswise.com, 4d ago
Despite advances in pharmacotherapy, there remains a pressing need to revolutionize the approach to diabetes treatment. Better Therapeutics, Inc. BTTX was founded with a vision to create software that guides patients in addressing the behavioral and lifestyle-related root causes of diabetes and cardiometabolic diseases. To make this vision a reality the company developed a groundbreaking form of cognitive behavioral therapy (CBT) which is accessible via a patient's smartphone. The safety and efficacy of this approach were tested in multiple clinical studies, and AspyreRx became the first FDA-authorized therapy delivering CBT via software for the treatment of type 2 diabetes. Rooted in the belief that behaviors can be learned and transformed through systematic techniques and interventions, AspyreRx offers a personalized experience to support patients in making meaningful and lasting behavioral changes to enhance their diabetes management. Delivered digitally, AspyreRx helps overcome many of the traditional limitations with in-person CBT, as a patient can access the treatment at their convenience.Benzinga, 4d ago
The system’s seamless automation capabilities further enhance its appeal, allowing it to intelligently adjust lighting and other electrical devices as occupants move from one room to another. Ultimately, Moez’s innovation holds great promise for not only reducing energy bills but also curbing carbon emissions through more efficient energy management. This light switch is a game-changing innovation in smart home technology and sustainable living. With the potential to revolutionise how homes are wired and managed, it offers a cost-effective and eco-friendly solution that addresses the pressing challenges of our time.Electronics For You, 4d ago

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...“The partnership and collaboration between the investment management industry, the FCA and HM Treasury has created strong momentum for change, which is essential to deliver the innovation we need. It is vital the UK remains at the forefront of technological development. In my role as Chair, it has been a real pleasure to see the breadth and depth of expertise the UK has to offer in adopting and leveraging the technology that could underpin the next generation of asset management.”...Markets Media, 10d ago
Andrea Cavalleri, who has founded and is currently leading the research group, adds, "This work underscores the scientific and technological developments within the MPSD in Hamburg, where new experimental methods are constantly being developed to achieve new scientific understanding. We have been working on ultrafast electrical transport methods for nearly a decade and are now in a position to study so many new phenomena in non-equilibrium materials, and potentially to introduce lasting changes in technology."...phys.org, 20d ago
Andrea Cavalleri, who has founded and is currently leading the research group, adds: "This work underscores the scientific and technological developments within the MPSD in Hamburg, where new experimental methods are constantly being developed to achieve new scientific understanding. We have been working on ultrafast electrical transport methods for nearly a decade and are now in a position to study so many new phenomena in non-equilibrium materials, and potentially to introduce lasting changes in technology."...ScienceDaily, 21d ago
The ease of genetic manipulation in Drosophila melanogaster using the Gal4/UAS system has been beneficial in addressing key biological questions. Current modifications of this methodology to temporally induce transgene expression require temperature changes or exposure to exogenous compounds, both of which have been shown to have detrimental effects on physiological processes. The recently described auxin-inducible gene expression system (AGES) utilizes the plant hormone auxin to induce transgene expression and is proposed to be the least toxic compound for genetic manipulation, with no obvious effects on Drosophila development and survival in one wild-type strain. Here we show that auxin delays larval development in a widely-used fly strain, and auxin exposure in adult Drosophila induces observable changes in physiology and feeding behavior. We found that there is a dosage response to adult survival upon auxin exposure and low auxin concentrations alter feeding activity. Furthermore, auxin fed male and female flies exhibit a significant decrease in triglyceride levels and display altered transcription of fatty acid metabolism genes. Although fatty acid metabolism is disrupted, auxin does not significantly impact adult female fecundity or progeny survival, suggesting AGES may be an ideal methodology for studying limited biological processes. These results emphasize that experiments using temporal binary systems must be carefully designed and controlled for to avoid confounding effects and misinterpretation of results.elifesciences.org, 28d ago
There is still a long way to go, in terms of reaching international standards at scale. Some key issues that need addressing remain – access to the importation of raw materials to scale up local manufacturing and quality of packaging. We hope that the educational content provided at the Beauty West Africa conference will offer important insight into how to address some of the issues that hold the ‘Made in Nigeria’ beauty and cosmetics industry from reaching its full potential on an international scale.The Guardian Nigeria News - Nigeria and World News, 6d ago
David R. Liu’s research integrates chemistry and evolution to illuminate biology and enable next-generation therapeutics. His major research interests include the engineering, evolution, and in vivo delivery of genome editing proteins such as base editors and prime editors to study and treat genetic diseases; the evolution of proteins with novel therapeutic potential using phage-assisted continuous evolution (PACE); and the discovery of bioactive synthetic small molecules and synthetic polymers using DNA-templated organic synthesis and DNA-encoded libraries. Base editing—the first general method to perform precision gene editing without double-stranded breaks, and a Science 2017 Breakthrough of the Year finalist—as well as prime editing, PACE, and DNA-templated synthesis are four examples of technologies pioneered in his laboratory. These technologies are used by thousands of labs around the world and have enabled the study and potential treatment of many genetic diseases. Four base editing clinical trials are already underway to treat leukemia, hypercholesterolemia, sickle-cell disease, and beta-thalassemia, and the first clinical benefit of a base edited therapeutic in a T-cell leukemia trial has been reported.Events & Lectures, 4d ago

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While deploying AI solutions, it is important to proceed with caution given their evolving learning capabilities. The CAR strongly believes that there needs to be national oversight for AI applications, particularly as they relate to patient care. Best practices, rules, and regulations are necessary and should be monitored at a federal level. Despite the numerous benefits that AI could bring to patients and healthcare professionals, we must also remain cognizant of the potential risks associated with its application.Hospital News, 4d ago
There is an absence of standardized treatment as all treatment options are associated with risk of recurrence and there is a paucity of patient-applied modalities to directly combat with the existential threats of the invading warts symptoms. The management of genital warts can be very challenging and a substantial burden for patients. Continuous research, with the potential to clear the warts quickly, reduce the pain of treatment, and introduce more of patient-applied therapies to reduce the burden of repeated visits to clinics has paved a way for the leading pharma players to address and bridge the existing gaps in the treatment of warts. As some molecule probably will enter in market in upcoming years for Genital Warts, the market is supposed to experience immense growth in future.Medgadget, 4d ago
There is a lot to do before this CRISPR-based genome shredding technique can be used therapeutically. For example, the researchers noted that there are inefficiencies in the delivery modalities that need to be addressed. And it is important to note that the work published in Cell Reports does not detail a path to direct clinical implementation for this approach. But the results are promising evidence of CRISPR’s potential to treat not just glioblastoma but other hypermutated tumors, according to Christof Fellmann, PhD, study lead and corresponding author on the paper. “We see CRISPR as a gateway to a new therapeutic approach that won’t be subject to the possibility of tumor cell escape.”...Inside Precision Medicine, 4d ago

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...“From the treatment, it was found that many patients had tried to lose weight by various methods in the past, including behavior modification and exercise, but these may not have been enough to treat obesity. Therefore, patients who are eligible for surgical treatment You will be thoroughly prepared for surgery. It was found that patients were able to maintain a stable weight in the long term. In addition, it has been found that losing weight helps to improve the results of treating joint diseases. Reduce the rate of use of drugs to treat heart disease, lipids, and diabetes. It has been found that diabetes patients can be cured as high as 80% of all patients who undergo surgery. Especially in patients who have had diabetes for less than 10 years, there is a high cure rate of almost 100%. In addition, it also reduces symptoms of bone and joint disease. Including improving snoring and obstructive sleep apnea. Importantly, the results of losing weight also improve the mental health and social status of patients.” Asst. Prof. (Special) Dr. Patchaya...Archyde, 4d ago
Ayesha Iqbal, IEEE senior member and engineering trainer at the Advanced Manufacturing Training Centre added: "AI has significantly evolved in recent years, with applications in almost every business sector. However, there are some barriers preventing organisations and individuals from adopting AI, such as a lack of skilled individuals, complexity of AI systems, lack of governance, and fear of job replacement. With AI growing more rapidly than ever before, and already being tested and employed in education, healthcare, transportation, finance, data security, and more, it’s high time that the Government, tech leaders, and academia work together to establish standards and regulation for safe and responsible development of AI-based systems. This way, AI can be used to its full potential for the collective benefit of humanity."...electronicspecifier.com, 4d ago
This is critical due to the current inefficient state of drug discovery—which has a 3% average probability of success for any given drug and takes over 10 years to bring new treatments to market, leaving those diagnosed with untreated diseases waiting on solutions that may not be available in time. Researchers need better tools to swiftly identify challenges, save money and time, and shift incentives toward investing in rare, complicated, and ‘untreatable’ disease drug research and development.BioPharma Dive, 4d ago
The Executive Order on the development and use of artificial intelligence (AI) issued by President Biden on October 30 is a directive that contains no fewer than 13 sections. But two words in the opening line strike at the challenge presented by AI: “promise” and “peril.”As the document’s statement of purpose puts it, AI can help to make the world “more prosperous, productive, innovative, and secure” at the same that it increases the risk of “fraud, discrimination, bias, and disinformation,” and other threats.Among the challenges cited in the Executive Order is the need to ensure that the benefits of AI, such as spurring biomedical research and clinical innovations, are dispersed equitably to traditionally underserved communities. For that reason, a section on “Promoting Innovation” calls for accelerating grants and highlighting existing programs of the Artificial Intelligence/Machine Learning Consortium to Advance Health Equity and Researcher Diversity (AIM-AHEAD) program from the National Institutes of Health (NIH). And the Colorado School of Public Health is deeply involved in the initiative.ColoradoSPH helps ensure that artificial intelligence serves and empowers all peopleAIM-AHEAD is a national consortium of industry, academic and community organizations with a “core mission” to ensure that the power of AI is harnessed in the service of minorities and other groups historically neglected or poorly served by the healthcare system. A key focus – though not the only one – is using AI to probe electronic health records (EHRs), which can be rich sources of clinical and other data.“The goal of [AIM-AHEAD] is to use this technology to try to eliminate or better understand and address health disparities,” said Evelinn Borrayo, PhD, associate director of research at the Latino Research and Policy Center (LRPC) of ColoradoSPH and Director for Community Outreach and Engagement at the CU Cancer Center. “This consortium is about the inclusion of communities that historically tend to be left behind.” Borrayo and Spero Manson, PhD, director of the Centers for American Indian and Alaska Native Health (CAIANH) at ColoradoSPH, co-direct the North and Midwest Hub of the AIM-AHEAD initiative, a sprawling 15-state area. Both are also members of the AIM-AHEAD Leadership Core.The hub, which is housed within CAIANH and ColoradoSPH, serves a variety of “stakeholders” who can help to develop AI, including Hispanic/Latino community health organizations, tribal epidemiology centers, urban Indian health centers, and more.Addressing the shortfalls of AI and machine learning developmentManson acknowledged that the last decade has brought “an explosion of interest as well as investment” in exploring the promise of AI and machine learning (ML) – which uses algorithms to train computers to perform tasks otherwise assigned to humans – and applying that knowledge to improving healthcare.“There have been substantial areas of achievement in that regard,” Manson said. But he said the work has also revealed “substantial bias” in the algorithms and predictive models as they are applied to “underrepresented and marginalized populations.”He noted, for example, that the data in EHRs may be incomplete because of barriers to care that people face, including socioeconomic status, race and ethnicity, and geography. In that situation, AI and ML don’t correct for these factors because the technology uses the EHR itself to analyze the data and make predictions, Manson said.That’s why deepening the reservoir of data in EHRs and other repositories is imperative for the development of AI and ML, he said.“The idea is to improve healthcare for all citizens, not just those that have benefited narrowly in the past,” he noted.Improving the diversity of AI workforceIn addition, the workforce of scientists working on AI and ML lacks diversity, while the benefits of research in the field have not yet adequately spread to underserved communities, Manson said.The North and Midwest Hub has undertaken several “outreach and engagement” projects to meet the goals of AIM-AHEAD, with ColoradoSPH playing a significant role.For example, two pilot projects aim to build capacity for applying AI and ML to aid communities. In one, Clinic Chat, LLC, a company led by Sheana Bull, PhD, MPH, director of the mHealth Impact Lab at ColoradoSPH, is collaborating with Tepeyac Community Health Center, which provides affordable integrated clinical services in northeast Denver. The initiative, now underway, uses Chatbots to assist American Indian/Alaska Native and Hispanic/Latino people in diagnosing and managing diabetes and cancer.A second project is working toward incorporating AI and ML coursework into the curriculum for students earning ColoradoSPH’s Certificate in Latino Health.“It’s an opportunity to introduce students to how using AI and ML can help us understand and benefit the [Latino] population,” Borrayo said. The idea is to build a workforce with the skills to understand the unique healthcare needs of Latinos and apply AI and ML skills to meet them, she added.“One of the approaches we are also taking is reaching students in the data sciences,” Borrayo said. “We can give those students the background and knowledge about Latino health disparities so they can use those [AI and ML] skills as well.”Building a generation that uses AI to improve healthcareManson also noted that the North and Midwest Hub supports Leadership and Research fellowship programs, which are another component of what he calls “an incremental capacity-building approach” to addressing the goals of AIM-AHEAD.“We’re seeking to build successive generations, from the undergraduate through the doctoral/graduate to the early investigator pipeline, so these individuals move forward to assume positions of leadership in the promotion of AI and ML,” Manson said.Borrayo said that she is most interested in continuing to work toward applying solutions for these and other issues in communities around the region. She pointed to the Clinic Chat project as an example of how AI and ML technology can be used to address practical clinical problems.“I think understanding the data, algorithms and programming is really good for our underrepresented investigators to learn,” she said. “But for our communities, I think the importance lies in the application.How can we benefit communities that are typically left behind or don’t have access to healthcare in the ways most of us do?”For Manson, a key question is how members of American Indian/Alaska Native, Latino, and other communities can “shift” from being “simply consumers and recipients” of work in AI and ML and “become true partners” with clinicians and data specialists in finding ideas that improve healthcare.“The field will be limited in terms of achieving the promise [of AI and ML] until we have that kind of engagement with one another,” Manson said.cuanschutz.edu, 4d ago
Nanobodies, also known as single-domain antibodies or VHHs, are derived from the immune systems of camelids and are heavy-chain-only antibodies. Despite their small size, they possess similar antigen-binding capabilities as conventional antibodies. Due to their unique properties such as tissue penetration, stability, and solubility, nanobodies have played a pivotal role in the development of many therapeutics and diagnostics. There is a vast array of nanobodies that have been developed to target a wide range of molecular targets. However, knowing the precise sequence of nanobodies is crucial to fully harness their potential in developing nanobody-based technologies.Rapid Novor, 4d ago
There is a solution to all of this: a skyhook, a space structure that could lift materials from Earth to near-Earth orbit and beyond. The ability to deal with junk and construct structures in space requires a paradigm shift, one that encourages us to seek opportunities and potential that might otherwise go untapped.Aeon, 4d ago

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Addressing the audience, Ms. Amanda Serumaga, UNDP Mauritius and Seychelles Resident Representative, stated: “As we embrace the potential of organic scanners, it is crucial to recognize that their success depends on collaboration. Governments, researchers, conservationists, and local communities must work hand in hand to integrate these technologies into comprehensive invasive species management strategies. Public awareness and education are essential components of this collaborative effort, ensuring that the benefits of organic scanners are understood and embraced on a global scale.”...UNDP, 4d ago
From an economic standpoint, it is crucial for the government to establish a solid and accurate domestic carbon pricing system that aligns with the actual societal costs associated with carbon emissions. To achieve this, the government must set a carbon price that is neither too high nor too low, effectively encouraging emission reductions while avoiding practices that heavily rely on carbon. Incorrect pricing could disrupt the market balance for these products. It’s also important to consider such policies’ potential initial financial burdens, underscoring the need to incentivize businesses that implement eco-friendly technologies and practices. These incentives include tax deductions, subsidies for adopting green technologies, or improved access to financing for environmentally friendly initiatives.Modern Diplomacy, 5d ago
Factors Affecting the Growth of the Leisure Travel Industry:• Enhanced Travel Infrastructure:Upgraded airports, expanded flight routes, and efficient public transportation systems connect travelers to a broader range of destinations. Enhanced connectivity makes it easier for people to access leisure destinations, thereby increasing the convenience of travel. Modern transportation infrastructure, including high-speed railways and well-maintained highways, reduces travel times between destinations. This is making it more appealing for travelers to explore multiple locations within a limited timeframe, encouraging leisure travel. Improved infrastructure also allows travelers to reach remote and less explored areas. This is opening new opportunities for adventure tourism, eco-tourism, and off-the-beaten-path experiences, attracting a diverse range of travelers.• Rising Trend of Sustainable Travel:Travelers are becoming more environment conscious and are actively seeking destinations and accommodations that prioritize sustainability. This includes choosing eco-friendly transportation options, such as electric or hybrid vehicles, and accommodations with green certifications. In addition, sustainable and eco-friendly accommodations, such as eco-lodges, green hotels, and eco-resorts, are gaining traction. Travelers are willing to pay more for lodging options that implement energy-saving measures, waste reduction, and conservation efforts. Moreover, sustainable travel often involves exploring natural environments and participating in outdoor activities. Destinations with pristine natural landscapes and eco-adventures, such as hiking, wildlife safaris, and eco-tours, attract travelers looking for immersive and environment friendly experiences.• Increasing Social Media Influence:Travelers are exposed to captivating travel photos, videos, and stories on platforms that inspire wanderlust and encourage individuals to explore new destinations and experiences. User-generated content (UGC) including travel reviews, photos, and personal narratives, provides authentic and relatable insights into destinations and accommodations. Travelers trust recommendations from peers and fellow travelers shared on social media. Besides this, social media platforms allow users to take virtual tours of destinations through 360-degree photos and videos. This immersive content enables travelers to explore a place before visiting, helping them make more informed choices.Leisure Travel Market Report Segmentation:By Traveler Type:• Solo...openPR.com, 5d ago
The climate crisis has forced us to re-examine the ways we feed ourselves and to question the best practices for what and how to eat – and especially, why to eat. Author Taras Grescoe (Bottomfeeder, The Devil’s Picnic) travels the world to uncover some traditional and ancient practices that, if widely adopted by Western industrialized nations, could become the future of food and agriculture, and help heal the planet. It is an outstanding and crucial read amid this global emergency.Quill and Quire - Canada's magazine of book news and reviews, 5d ago
We’re in the midst of an automotive renaissance, with most of the excitement and innovation stemming from the burgeoning EV industry. Automakers are finding new ways to make cars lighter, and are also creating new body styles that look and feel modern without the quirky appearance of EVs of the past. Electric vehicles don’t have to be boring anymore, and we’re seeing creativity with how companies approach accessories, interior materials, and even tires. It’s clear the industry has turned when Lamborghini finds a way to build a hybrid powertrain that makes the car even more powerful than before, adding a touch of green without sacrificing the brand’s character. Below are the automotive innovations we’re most excited about.Popular Science, 5d ago
Geothermal resources are available virtually everywhere underground, representing a potentially vast supply of clean electricity and industrial heat. Yet most of those resources are too deep or technically complicated to access in a cost effective way using traditional methods. Fervo, which has raised more than $180 million since 2017, is among dozens of companies in the U.S. and worldwide that are working to develop easier and cheaper ways of unleashing the potential of geothermal energy.CleanTechnica, 5d ago

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Michael Levin 18:31 Yeah, I mean, I think I think some of the short term applications are looking at just based on what we've seen, what we show in this paper, looking at the things like various kinds of wounds, so you know, is neural wounds, for example, maybe retinal defects, maybe various other kinds of lesions in epithelial and things like that. I think it's also important to think about the long term impact here, which is that in addition to whatever immediate work, these functional bots are going to be put to do it this whole platform has has also one other kind of major potential impact, which is the use of it as a almost like a sandbox in which to learn to understand the Morpho genetic code. That is how do we convince groups of cells to do one thing versus another that is critical for repair of birth defects, regeneration, after injury, normalization of cancer, prevention of degenerative disease, all of those aspects of regenerative medicine, hang on our ability to control what it is that cells build. And I think these kinds of synthetic synthetic constructs to help us do the experiments that really show us what what the plasticity of the cells look like, what can they do besides what they normally do in the body? And that helps us to develop novel interventions that really won't necessarily have anything to do with bio robots. But someday in the future, when we have regenerative medicine, where we know how to When do cells how to how to coax cells to grow various missing organs or replace aging structures in the body, and so on. It will be because we worked out those rules of stimulus and response in these kinds of these kinds of models. So I see, you know, sort of short short term application and neural repair and sensing bacteria and, you know, working with cancer cells and so on. And then, and then there's the longer term of using these kinds of synthetic systems to work out a way to communicate our regenerative medicine goals to collections of cells.newswise.com, 5d ago
I hope that we continue to utilise technology and innovation to improve access to public transport for all people. It is important to ensure that technological advances don’t lead to inequities – different needs, abilities and circumstances require different solutions. For some, that means the ability to plan, book and pay for their trip using a cell phone or smartwatch, but, for others, that means being able to speak to a trip planner and pay with cash. I hope that automation is implemented in a way that improves mobility for all without increasing congestion. And I hope that public transport continues to help us to reduce our carbon footprint on this planet. This industry has evolved so rapidly in the last 10 years and is meeting the needs of so many more people than ever before – I hope that that evolution continues well into the future.Intelligent Transport, 5d ago
With this investment, Infinium’s eSAF, eDiesel, and eNaphtha are poised to offer ultra-low carbon solutions not just for aviation but also for long-haul transportation, maritime shipping, and the chemical industries. Infinium’s eSAF is a particularly promising product due to its compatibility with existing aviation fuel infrastructure and its potential to decarbonize planes with minimal adjustments.IO, 5d ago

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...“At a high level, just the idea of operating a printer on vision-based feedback control at the voxel level is not new (e.g., MultiFab in 2015). What turned out to be extremely difficult was how to make this technology work at scale and with multiple materials. Inkbit and my lab’s team at ETH Zurich closely collaborated on this technological refinement and what can be made with the technology starting in 2020. While the printer hardware creation happened at Inkbit and the print design and iterations at ETH Zurich, it is not possible to easily dissect who did exactly what in this collaboration since we optimized the print technology together in a team through daily interactions. Our many test prints stress-tested the system and helped the team to find the right vision and print parameters and material formulations to make functional prints work. Before the collaboration, Inkbit was using a completely different scanning method based on Optical Coherence Tomography. That was a dead end that turned out to be too slow; about the time when my team joined the collaboration in 2020, a complete redesign and rebuild of the scanning system happened.”...3DPrint.com | The Voice of 3D Printing / Additive Manufacturing, 17d ago
Volcano geoengineering is the practice of altering the state of volcanic systems and/or volcanic eruptions to exploit them or mitigate their risk. Although many in the field insist there is little that can be done to mitigate the hazard, past examples of both intentional and inadvertent volcano interventions demonstrate that it is technically feasible to reach volcano plumbing systems or alter atmospheric processes following eruptions. Furthermore, we suggest that economical, political, and environmental pressures may make such interventions more common in the future. If volcano geoengineering ever becomes a discipline, it will need to overcome many safety and ethical concerns, including dealing with uncertainty, deciding on philosophical approaches such as a consequentialism or precautionary principle, justice and inequality, military uses, cultural values, and communication. We highlight that while volcano geoengineering has significant potential benefits, the risks and uncertainties are too great to justify its use in the short term. Despite this, because of the potential large benefits to society, we believe there is a strong ethical case to support research into the efficacy and safety of volcano geoengineering for its potential future use. We propose that rigorous governance and regulation of any volcano geoengineering is required to protect against potential risks, to enable potentially valuable and publicly available research (e.g., quantification of efficacy and safety), to ensure that any future policy must be co-created through community engagement, and that volcano geoengineering should only be considered as part of larger mitigation practices.nationalaffairs.com, 5d ago
The options might then include adaptive therapy, which is a dynamic approach that aims to prevent cancer progression instead of trying to kill as many cancer cells as possible. The idea is that by stopping and adjusting chemotherapy, clinicians leave some treatment-responsive cancer cells alive. This stops treatment-resistant cells from taking over and growing out of control. Although patients must live with some tumor burden, they receive lower doses of toxic cancer-killing medications, shielding them from the worst of the side effects. Adaptive therapy with abiraterone, a prostate cancer drug discovered at the ICR, has already proven successful in a clinical trial.phys.org, 6d ago
Our recently published data show that NMII is required for B-cell contraction (Seeley-Fallen et al. 2022). Activated NMII is recruited to the B-cell contact zone in a SHIP-1-dependent manner. NMII levels reach a plateau at the beginning of B-cell contraction, and NMII forms a peripheral ring surrounding the contact zone during B-cell contraction. Here, we further show that in addition to SHIP-1, N-WASP but not WASP is also involved in NMII recruitment and NMII ring-like structure formation, probably by initiating the generation of inner F-actin foci. Collectively, these findings suggest that SHIP-1 coordinates with N-WASP to recruit NMII. Our previous finding that SHIP-1 promotes B-cell contraction by facilitating N-WASP activation (Liu et al. 2011; Liu et al. 2013a) supports this notion. However, it is surprising that the recruitment of NMII activated by BCR signaling to the contact zone is associated with inhibitory signaling molecules. BCR downstream signaling, including Ca2+ fluxes and Rho-family GTPase activation, likely activates NMII motor activity (Vicente-Manzanares et al. 2009). The activation switches NMII from the incompetent folded conformation to the competent extended conformation, enabling NMII molecules to bind to F-actin and assemble into contractible bipolar filaments and stacks (Matsumura 2005). A denser F-actin organization has been shown to increase NMII filament stacking (Fenix and Burnette 2018). Here, we showed that the inner F-actin foci generated by N-WASP-activated Arp2/3 are more stable and denser and thus likely promote NMII binding and stacking more efficiently than F-actin generated by WASP-activated Arp2/3. Indeed, our kymograph analysis revealed similar time windows and spatial locations for NMII accumulation and for generating inner F-actin foci from lamellipodial F-actin, supporting our hypothesis. While NMII recruitment is facilitated by inner F-actin foci, the motor activity of NMII is required for the formation of the ring-like structures of inner F-actin foci in return, likely by driving their centripetal movement, thereby providing mechanical feedback for actin reorganization. However, the structural organization of inner F-actin foci and recruited NMII and their coordinated dynamics require further analysis with higher-resolution microscopy techniques.elifesciences.org, 19d ago
...sitem-insel is the Swiss Institute for Translational Medicine and Entrepreneurship. Its mission is to bring research to patients as quickly as possible and to the highest quality. This means creating structures that make it possible to implement ideas from everyday clinical practice in such a way that they can be used successfully on the market. The boundaries are fluid, the rapid and meaningful networking of players brings success. sitem-insel is located on the Insel Campus Bern and benefits from its proximity to Switzerland's largest university hospital (Inselspital) and the University of Bern. Under one roof, sitem-insel brings together a wide variety of clinical, industrial, research and educational units that pursue innovation for the benefit of patients. The architecture of the 20,000 m2 transparent glass building reflects the idea of openness and multidisciplinary collaboration.empa.ch, 24d ago
The Internet of Medical Things (IoMT) has the capacity to bring about substantial enhancements in healthcare by enhancing access to medical information and services, reducing expenses, and elevating the standard of care. Illustrations of IoMT applications in healthcare encompass remote patient monitoring, telemedicine, and electronic medical records. These technological advancements have the potential to bridge the healthcare access gap that exists among urban and rural areas as well as different socioeconomic groups. Consequently, there is an increasing requirement for the Internet of Medical Things, leading to its swift growth in order to cater to crucial healthcare demands.Medgadget, 27d ago

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Nowadays, it is rather hard to imagine a company offering breakthrough innovations in the field of capacitor design. Indeed, as far as the most basic parameters are concerned, one brand’s products do not differ significantly from the competitive solutions. Nevertheless, as a result of extensive R&D activities, slight improvements as well as structural solution modifications and production process streamlining, Panasonic has developed an extensive portfolio of components characterised by extremely high quality. Moreover, it includes major innovations that make it possible to design equipment that is not only durable, but also even more compact than before.ELE Times, 5d ago
Ms. Neuberger then points to the defense sector, which relies increasingly on robust connectivity. She hints at the incredible potential for the U.S. Department of Defense (DoD) to leverage commercial-off-the-shelf (COTS) cellular platforms to host bespoke solutions (both existing and new) that meet the unique needs of our warfighters. The same is true of other large industries such as manufacturing, medicine, and transportation. These industries represent enormous potential sources of new revenue to cellular carriers. They already have massive IT solutions serving billions of customers today and will create huge value if they migrate smoothly to work onto wireless networks. However, first we need to drive some architectural changes to the wireless networks that will allow these innovations to be incorporated profitably.6GWorld, 5d ago
Newswise — A research team at The Ohio State University Wexner Medical Center and College of Medicine has been approved for a $14 million award from the Patient-Centered Outcomes Research Institute (PCORI) to study whether a higher daily dose of aspirin is more effective in decreasing the risk of dangerous blood pressure complications among some pregnant people.During pregnancy, people are at risk of developing preeclampsia and gestational hypertension. Both disorders are characterized by high blood pressure and bring with them the potential for injury to the brain, lungs, kidneys and liver. These hypertensive disorders impact nearly one in seven pregnant individuals, are increasing by about 10% every year, and disproportionately affect minoritized communities and other groups with historical disadvantage.“Currently, delivering the baby is the only treatment for these conditions, which often means babies are born too early and have increased risks for complications such as bleeding in the brain and infections,” said the study’s principal investigator Maged Costantine, MD, division director of maternal fetal medicine at Ohio State Wexner Medical Center and professor of obstetrics and gynecology. “Given the high frequency, related complications, and inequities, it is important to improve treatment methods.”Many professional societies, such as the Society for Maternal-Fetal Medicine, say that pregnant people at higher risk of these hypertensive disorders should take low-dose aspirin every day to prevent these blood pressure complications.“While 81mg is most often used, a higher dose may work better for patients, although that possibility has not been evaluated adequately”, said co-principal investigator Kara Rood, MD, maternal fetal medicine physician and associate professor at Ohio State. “It is also important to identify whether aspirin works equally well for everyone, for example those with diabetes versus those with chronic hypertension, and to understand any barriers to adhering to recommended low-dose aspirin therapy.”The study also will be led by co-principal investigator Denise Scholtens, professor and division chief of biostatistics in preventive medicine at Northwestern University Feinberg School of Medicine and director of Northwestern’s Data Analysis and Coordinating Center. Other key study investigators at Ohio State include William Grobman, MD, maternal fetal medicine physician and professor of obstetrics and gynecology; Ann Scheck McAlearney, ScD, professor of family medicine, associate dean for health sciences research and director of CATALYST; Anne Trinh, MPH, director of programs and strategic initiatives at the Center for HOPES; and Melanie Paglione, RN, the consortium’s lead research nurse coordinator. At Northwestern, Kiarri Kerhaw, PhD, associate professor and social epidemiologist, will assist in approach and data interpretation as well. The research team aims to enroll more than 10,000 pregnant people at higher risk for hypertensive disorders in pregnancy at 11 clinical centers across the U.S. Participants will be randomized to two groups; one will take 81mg aspirin daily and the other will take 162mg daily. They will be followed until six weeks after delivery. Researchers will compare the two groups according to the frequency of developing hypertensive disorders, their overall health and birth experience, and whether they have a baby who is born too small or too early, receives special care after delivery, has issues with bonding, or does not survive. “This study will help answer an important question that will improve the health of all pregnant people and their babies and may also reduce health disparities,” said Costantine. “When completed, this will be the largest and most up-to-date study focused on the ideal dose of aspirin to prevent blood pressure problems in pregnancy.”“This project was selected for PCORI funding not only for its scientific merit and commitment to engaging patients and other healthcare stakeholders, but also for its conduct in real-world settings,” said Nakela L. Cook, MD, MPH, PCORI executive director. “It has the potential to answer an important question about prevention of hypertensive disorders of pregnancy and fill a crucial evidence gap. We look forward to following the study’s progress and working with the Ohio State University to share its results.” Many clinical studies test whether an approach to care works under carefully controlled conditions in specialized research centers, but health care is rarely delivered in such optimized settings. Pragmatic clinical studies test a treatment’s effectiveness in “real-world” practice situations, such as typical hospitals and outpatient clinics, and also can include a wider range of study participants, making their findings more generally applicable. Ohio State’s funding award has been approved pending completion of a business and programmatic review by PCORI staff and issuance of a formal award contract.PCORI is an independent, nonprofit organization authorized by Congress in 2010. Its mission is to fund research that will provide patients, their caregivers and clinicians with the evidence-based information needed to make better informed healthcare decisions.newswise.com, 5d ago
...“We have developed a simple tool that can identify all of the genetic material in bacteria. This allows us to find out more quickly what kind of bacteria a sick person or animal is affected by, or what kind of bacteria are found in food or the environment. We can then also decide whether it is necessary to use antibiotics against the bacterium, and if so what kind, so we don’t have to use as much medication,” says Professor Erika Eiser at Norwegian University of Science and Technology's (NTNU)Department of Physics.newswise.com, 5d ago
Artificial Intelligence technology can transform the entire hotel room into a desirable tourist spot. After entering the hotel room, the customers can select the option to transform their entire room into their favorite destination. By selecting such an option, the entire room is transformed into a virtual 3 D world that resembles their favorite destination. The customer can experience the 3 D view of their destination inside the room. Future AI technologies may solve issues by incorporating more robust blockchain technologies that assure data privacy & security. In the future, we may see Robots serving hotel guests by directing them to their room, carrying their luggage, serving them food & snacks, housekeeping services, etc. This technology is currently used in a few hotels. In the future, the Visual Positioning System (VPS) may take over the Global Positioning System (GPS). VPS is an advanced technology that provides a live view of the real world & visual landmarks in front of travelers in the form of shops, companies, hotels, malls, cinema theatres, restaurants, canteens, recreational zones, etc., thereby providing Location-based experiences. There might be many more untouched and unexpected points related to service and customer touchpoints, where AI may be applied in the future.DATAQUEST, 5d ago
Against the backdrop of automation and the mega-trend of digitalization, earlier pathways of labour-intensive industrialization are becoming increasingly unlikely to foster the development of countries in special situations. This is particularly the case for LDCs, many of which have significant proportions of their labour force engaged in low-productivity agriculture. Moreover LDCs, LLDCs and SIDS in Asia and the Pacific exhibit low levels of digitalization and face unique challenges in harnessing the benefits of such technologies due to, for example, limited resources, inadequate infrastructure, a low-skilled workforce, and vulnerable economies. All these factors hinder the ability of countries in special situations to fully participate in the digital revolution.ESCAP, 5d ago

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One takeaway for me from these discussions is, unsurprisingly, anthropological. Cultures tend to categorize things in the world as good or bad, right or wrong, us or them, that sort of thing. So, I noticed these interesting categorical tensions between things like open source vs. proprietary models, as well as a tension between innovation vs. risk. What I heard was a tension between developing and deploying AI — which is happening at the speed of engineering — and the need to tackle AI safety and characterize risk, which is happening at the speed of science. The latter is much slower than the former. Very smart people are trying to figure out how we can thread this needle of realizing AI’s promise at the speed of engineering, while also recognizing that we have to move faster on building the science of AI safety — because once we realize some of these risks, given their potential magnitude, it might be too late to some degree.USC Today, 17d ago
Peoples and colleagues estimate that erroneous citation has been rampant for nearly a century and warn that the emerging powers of artificial intelligence will enable this trend to flourish “with an efficiency and scale not previously possible.” Citations in biomedical literature build an evidence base that helps direct care through, for example, clinical guidelines. But, as the world gets to grips with the AI revolution, how does medicine evaluate new AI tools and ensure that the evidence base they build is of benefit to patients and doctors? Of particular concern is the “black box” nature of the technology, with some AI researchers unsure how it comes to its findings. AI has the potential to help doctors make sense of complex medical data and broaden or refine diagnostic thinking, says Chris Stokel-Walker (10.1136/bmj.p2362 ), but it is important to develop frameworks to check AI’s homework.3 The time to act is clearly now—and the UK is ahead of many, with its careful approach requiring its regulator to approve the use of any system before it can be used to treat patients.The BMJ, 25d ago
Snakehead, Channa striata, are a high-value and popular aquaculture species but have had a long history of invasion in the Mekong Delta and other regions of the world resulting in negative impacts on native aquatic species biodiversity. A bacterial disease known as internal white spot disease caused by Aeromonas schubertii is a major problem in the production of snakehead. This study was aimed at characterizing the prevalence of antibiotic resistance in bacterial isolates collected from farms in the Mekong Delta region due to the potential public health concern should multi-antibiotic resistant (MAR) bacteria spread to wild populations or to consumers. Isolates were collected from white nodules in affected fish and identified based on morphological and biochemical tests, combined with an analysis of housekeeping genes (16S rRNA, gyrB, and rpoD). Disease causing isolates were strongly identified as A. schubertii, and it was found that all isolates (n = 25) were phenotypically multidrug-resistant, with resistance to erythromycin (84%), rifampicin (84%), flumequine (88%), amoxicillin (96%), ciprofloxacin (92%), and florfenicol (92%). The MAR indices ranged from 0.33 to 0.92, with one isolate of A. schubertii showing resistance to 11 of the 12 antibiotics tested. Further hierarchical clustering analysis of antibiotic-resistant bacteria suggested the potential to spread between ponds/fish farms and the ability for bacteria to survive for up to 3 months in aquatic environments. These results suggest that the diversity of MAR A. schubertii in snakehead represents a potential risk to native aquatic organisms and consumers, and emphasize the need for judicial use of antibiotics in aquaculture to limit the development of MAR bacterial species.was.org, 14d ago